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Article: Impact of second primary malignancy on outcomes of differentiated thyroid carcinoma

TitleImpact of second primary malignancy on outcomes of differentiated thyroid carcinoma
Authors
Issue Date2010
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/surg
Citation
Surgery, 2010, v. 148 n. 6, p. 1191-1196 How to Cite?
AbstractBackground: There are few data on the degree to which thyroid cancer survivors are at risk of second primary malignancy (SPM). This study aimed at evaluating the risk of SPM in patients with differentiated thyroid carcinoma (DTC) and how the timing of SPM might affect the disease course. Methods: Among 1,043 patients diagnosed with DTC between 1970 and 2008, 27 (2.6%) had synchronous SPM (ie, diagnosed within 6 months of DTC) and 71 (6.8%) had metachronous SPM (ie, diagnosed >6 months after DTC) in 10,419 person-years of follow-up. Standardized incidence ratios were estimated overall and for each SPM site. Results: DTC survivors had a 39% greater risk of SPM (SIR = 1.39; 95% CI, 1.09-1.73) compared to the general population. Those with SPM had a worse overall survival than those without SPM (P < .001). The synchronous group had a worse DTC-specific survival (P = .002), whereas the metachronous group had a worse SPM-specific survival (P = .042). A lesser proportion in the metachronous group were able to receive curative treatment for SPM (32/71 vs 20/27; P = .013). Conclusion: DTC survivors had an increased risk of SPM. The occurrence of SPM adversely affected the survival of DTC. The synchronous group tended to die from DTC, whereas the metachronous group from SPM. Heightened postoperative surveillance might improve survival. © 2010 Mosby, Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/142514
ISSN
2015 Impact Factor: 3.309
2015 SCImago Journal Rankings: 1.620
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLang, BHHen_HK
dc.contributor.authorLo, CYen_HK
dc.contributor.authorWong, IOLen_HK
dc.contributor.authorCowling, BJen_HK
dc.date.accessioned2011-10-28T02:50:13Z-
dc.date.available2011-10-28T02:50:13Z-
dc.date.issued2010en_HK
dc.identifier.citationSurgery, 2010, v. 148 n. 6, p. 1191-1196en_HK
dc.identifier.issn0039-6060en_HK
dc.identifier.urihttp://hdl.handle.net/10722/142514-
dc.description.abstractBackground: There are few data on the degree to which thyroid cancer survivors are at risk of second primary malignancy (SPM). This study aimed at evaluating the risk of SPM in patients with differentiated thyroid carcinoma (DTC) and how the timing of SPM might affect the disease course. Methods: Among 1,043 patients diagnosed with DTC between 1970 and 2008, 27 (2.6%) had synchronous SPM (ie, diagnosed within 6 months of DTC) and 71 (6.8%) had metachronous SPM (ie, diagnosed >6 months after DTC) in 10,419 person-years of follow-up. Standardized incidence ratios were estimated overall and for each SPM site. Results: DTC survivors had a 39% greater risk of SPM (SIR = 1.39; 95% CI, 1.09-1.73) compared to the general population. Those with SPM had a worse overall survival than those without SPM (P < .001). The synchronous group had a worse DTC-specific survival (P = .002), whereas the metachronous group had a worse SPM-specific survival (P = .042). A lesser proportion in the metachronous group were able to receive curative treatment for SPM (32/71 vs 20/27; P = .013). Conclusion: DTC survivors had an increased risk of SPM. The occurrence of SPM adversely affected the survival of DTC. The synchronous group tended to die from DTC, whereas the metachronous group from SPM. Heightened postoperative surveillance might improve survival. © 2010 Mosby, Inc. All rights reserved.en_HK
dc.languageengen_US
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/surgen_HK
dc.relation.ispartofSurgeryen_HK
dc.subject.meshCell Differentiationen_US
dc.subject.meshNeoplasms, Second Primary - complications - epidemiology - mortality - radiotherapyen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshThyroid Neoplasms - complications - epidemiology - mortality - pathology - radiotherapy - secondary - surgeryen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleImpact of second primary malignancy on outcomes of differentiated thyroid carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0039-6060&volume=148&issue=6&spage=1191&epage=1196&date=2010&atitle=Impact+of+second+primary+malignancy+on+outcomes+of+differentiated+thyroid+carcinomaen_US
dc.identifier.emailWong, IOL: iolwong@hku.hken_HK
dc.identifier.emailCowling, BJ: bcowling@hku.hken_HK
dc.identifier.authorityWong, IOL=rp01806en_HK
dc.identifier.authorityCowling, BJ=rp01326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.surg.2010.09.022en_HK
dc.identifier.pmid21134551-
dc.identifier.scopuseid_2-s2.0-78649926165en_HK
dc.identifier.hkuros183823en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78649926165&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume148en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1191en_HK
dc.identifier.epage1196en_HK
dc.identifier.isiWOS:000286088900035-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLang, BHH=7201907327en_HK
dc.identifier.scopusauthoridLo, CY=16417392800en_HK
dc.identifier.scopusauthoridWong, IOL=7102513940en_HK
dc.identifier.scopusauthoridCowling, BJ=8644765500en_HK

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