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Article: A role for c-Myc in regulating anti-mycobacterial responses

TitleA role for c-Myc in regulating anti-mycobacterial responses
Authors
KeywordsCytokine
Macrophages
Issue Date2011
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 2011, v. 108 n. 43, p. 17749-17754 How to Cite?
Abstractc-Myc (Myc) is a well known transcription factor that regulates many essential cellular processes; however, its role in modulating immunity is not known. Here, we showed different species of mycobacteria can induce Myc expression via ERK1/2 and JNK activation. Unexpectedly, the induced Myc is localized in the cytoplasm but not in the nucleus. This induced Myc expression is associated with the induction of TNF-α and IL-6 and with the suppression of intracellular mycobacterial growth. To delineate the underlying mechanisms, we demonstrated that Myc enhances IRAK1 degradation, leading to specific activations of ERK1/2 and p38 MAPK but not Akt, and reduces IκBα protein recovery upon degradation. Hence, our findings may provide insights into a potential role for Myc in regulating the antimicrobial responses.
Persistent Identifierhttp://hdl.handle.net/10722/142454
ISSN
2015 Impact Factor: 9.423
2015 SCImago Journal Rankings: 6.883
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU 769810M
Hong Kong Research Fund for the Control of Infectious Diseases09080512
University of Hong Kong
Li Ka Shing Faculty of Medicine
Funding Information:

This project was supported in part by Hong Kong Research Grants Council Grant HKU 769810M (to A.S.Y.L.) and Hong Kong Research Fund for the Control of Infectious Diseases Grant 09080512 (to A.S.Y.L.). H.C.H.Y. is the recipient of a postgraduate studentship from the University of Hong Kong and is supported in part by the Chung Kue Suen Research Fund, Li Ka Shing Faculty of Medicine.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorYim, HCHen_HK
dc.contributor.authorLi, JCBen_HK
dc.contributor.authorPong, JCHen_HK
dc.contributor.authorLau, ASYen_HK
dc.date.accessioned2011-10-28T02:46:21Z-
dc.date.available2011-10-28T02:46:21Z-
dc.date.issued2011en_HK
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2011, v. 108 n. 43, p. 17749-17754en_HK
dc.identifier.issn0027-8424en_HK
dc.identifier.urihttp://hdl.handle.net/10722/142454-
dc.description.abstractc-Myc (Myc) is a well known transcription factor that regulates many essential cellular processes; however, its role in modulating immunity is not known. Here, we showed different species of mycobacteria can induce Myc expression via ERK1/2 and JNK activation. Unexpectedly, the induced Myc is localized in the cytoplasm but not in the nucleus. This induced Myc expression is associated with the induction of TNF-α and IL-6 and with the suppression of intracellular mycobacterial growth. To delineate the underlying mechanisms, we demonstrated that Myc enhances IRAK1 degradation, leading to specific activations of ERK1/2 and p38 MAPK but not Akt, and reduces IκBα protein recovery upon degradation. Hence, our findings may provide insights into a potential role for Myc in regulating the antimicrobial responses.en_HK
dc.languageengen_US
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_HK
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_HK
dc.subjectCytokineen_HK
dc.subjectMacrophagesen_HK
dc.subject.meshImmunity, Innate - immunology-
dc.subject.meshInterleukin-1 Receptor-Associated Kinases - metabolism-
dc.subject.meshMAP Kinase Signaling System - immunology-
dc.subject.meshMycobacterium Infections - immunology-
dc.subject.meshProto-Oncogene Proteins c-myc - immunology-
dc.titleA role for c-Myc in regulating anti-mycobacterial responsesen_HK
dc.typeArticleen_HK
dc.identifier.emailLi, JCB: jamesli@hku.hken_HK
dc.identifier.emailLau, ASY: asylau@hku.hken_HK
dc.identifier.authorityLi, JCB=rp00496en_HK
dc.identifier.authorityLau, ASY=rp00474en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1073/pnas.1104892108en_HK
dc.identifier.pmid21997212-
dc.identifier.pmcidPMC3203812-
dc.identifier.scopuseid_2-s2.0-80055087050en_HK
dc.identifier.hkuros196776en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80055087050&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume108en_HK
dc.identifier.issue43en_HK
dc.identifier.spage17749en_HK
dc.identifier.epage17754en_HK
dc.identifier.eissn1091-6490-
dc.identifier.isiWOS:000296378100044-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectA role for oncogenes in the regulation of immune response to Mycobacterial infection-
dc.relation.projectFactors affecting mycobacteria evasion of immunity: effects of HIV on cellular signaling and kinases-
dc.identifier.scopusauthoridYim, HCH=15752404600en_HK
dc.identifier.scopusauthoridLi, JCB=23103447500en_HK
dc.identifier.scopusauthoridPong, JCH=54399148600en_HK
dc.identifier.scopusauthoridLau, ASY=7202626202en_HK
dc.identifier.citeulike10358874-

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