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Article: Infection of immunocompromised patients by avian H9N2 influenza A virus

TitleInfection of immunocompromised patients by avian H9N2 influenza A virus
Authors
KeywordsAvian influenza A H9N2
Bone marrow transplantation
Immunocompromised host
Issue Date2011
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinf
Citation
Journal Of Infection, 2011, v. 62 n. 5, p. 394-399 How to Cite?
AbstractAvian influenza A (H9N2) virus is transmitted sporadically from avian species to human causing mild diseases in immunocompetent person. We report two cases of human infection in immunocompromised patients in Hong Kong between 2008 and 2009. One patient had uneventful recovery with viral shedding at day 10 after symptom onset despite her underlying acute lymphoblastic leukaemia. The other patient with post-bone marrow transplant chronic graft-versus-host disease and bronhioltis obliterans went into respiratory failure. Genetic analysis revealed that these cases were caused by different genetic variants which are circulating in poultry in this region. Review of literature identified another 9 human cases reported in Southern China since 1988. It is possible that human infection with H9N2 is more common than what has been recognized. Continuous surveillance of H9N2 influenza virus infection in human is warranted. © 2011 The British Infection Society.
Persistent Identifierhttp://hdl.handle.net/10722/142419
ISSN
2015 Impact Factor: 4.382
2015 SCImago Journal Rankings: 2.070
ISI Accession Number ID
Funding AgencyGrant Number
Providence Foundation Limited
Research Fund for the Control of Infectious Diseases (RFCID) of the Food and Health Bureau and Research Grants Council of the Hong Kong Special Administrative Region, ChinaHKU 7488/05M
7500/06M
HKU 7619/07M
Funding Information:

The study is partly funded by the Providence Foundation Limited in memory of the late Dr. Lui Hac Minh and the Research Fund for the Control of Infectious Diseases (RFCID) of the Food and Health Bureau and Research Grants Council of the Hong Kong Special Administrative Region, China (HKU 7488/05M, 7500/06M and HKU 7619/07M).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorCheng, VCCen_HK
dc.contributor.authorChan, JFWen_HK
dc.contributor.authorWen, Xen_HK
dc.contributor.authorWu, WLen_HK
dc.contributor.authorQue, TLen_HK
dc.contributor.authorChen, Hen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorYuen, KYen_HK
dc.date.accessioned2011-10-28T02:45:37Z-
dc.date.available2011-10-28T02:45:37Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Infection, 2011, v. 62 n. 5, p. 394-399en_HK
dc.identifier.issn0163-4453en_HK
dc.identifier.urihttp://hdl.handle.net/10722/142419-
dc.description.abstractAvian influenza A (H9N2) virus is transmitted sporadically from avian species to human causing mild diseases in immunocompetent person. We report two cases of human infection in immunocompromised patients in Hong Kong between 2008 and 2009. One patient had uneventful recovery with viral shedding at day 10 after symptom onset despite her underlying acute lymphoblastic leukaemia. The other patient with post-bone marrow transplant chronic graft-versus-host disease and bronhioltis obliterans went into respiratory failure. Genetic analysis revealed that these cases were caused by different genetic variants which are circulating in poultry in this region. Review of literature identified another 9 human cases reported in Southern China since 1988. It is possible that human infection with H9N2 is more common than what has been recognized. Continuous surveillance of H9N2 influenza virus infection in human is warranted. © 2011 The British Infection Society.en_HK
dc.languageengen_US
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinfen_HK
dc.relation.ispartofJournal of Infectionen_HK
dc.subjectAvian influenza A H9N2en_HK
dc.subjectBone marrow transplantationen_HK
dc.subjectImmunocompromised hosten_HK
dc.subject.meshBone Marrow Transplantation - adverse effects-
dc.subject.meshImmunocompromised Host-
dc.subject.meshInfluenza A Virus, H9N2 Subtype - classification - genetics - isolation and purification-
dc.subject.meshInfluenza, Human - complications - diagnosis - pathology - virology-
dc.subject.meshRespiratory Insufficiency - diagnosis - etiology-
dc.titleInfection of immunocompromised patients by avian H9N2 influenza A virusen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, JFW: jfwchan@hku.hken_HK
dc.identifier.emailChen, H: hlchen@hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityChan, JFW=rp01736en_HK
dc.identifier.authorityChen, H=rp00383en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jinf.2011.02.007en_HK
dc.identifier.pmid21356238-
dc.identifier.scopuseid_2-s2.0-79956105325en_HK
dc.identifier.hkuros197228en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79956105325&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume62en_HK
dc.identifier.issue5en_HK
dc.identifier.spage394en_HK
dc.identifier.epage399en_HK
dc.identifier.isiWOS:000290790800009-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectMolecular basis of genesis and determinants for pathogenicity of avian influenza H5N1 virus genotype Z-
dc.identifier.scopusauthoridCheng, VCC=38662328400en_HK
dc.identifier.scopusauthoridChan, JFW=24278817900en_HK
dc.identifier.scopusauthoridWen, X=36060825600en_HK
dc.identifier.scopusauthoridWu, WL=16835478800en_HK
dc.identifier.scopusauthoridQue, TL=7003786628en_HK
dc.identifier.scopusauthoridChen, H=26643315400en_HK
dc.identifier.scopusauthoridChan, KH=35338760600en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK

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