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Article: Infection of immunocompromised patients by avian H9N2 influenza A virus
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TitleInfection of immunocompromised patients by avian H9N2 influenza A virus
 
AuthorsCheng, VCC3
Chan, JFW3
Wen, X1 3
Wu, WL1 3
Que, TL2
Chen, H3 1
Chan, KH3
Yuen, KY3 1
 
KeywordsAvian influenza A H9N2
Bone marrow transplantation
Immunocompromised host
 
Issue Date2011
 
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinf
 
CitationJournal Of Infection, 2011, v. 62 n. 5, p. 394-399 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jinf.2011.02.007
 
AbstractAvian influenza A (H9N2) virus is transmitted sporadically from avian species to human causing mild diseases in immunocompetent person. We report two cases of human infection in immunocompromised patients in Hong Kong between 2008 and 2009. One patient had uneventful recovery with viral shedding at day 10 after symptom onset despite her underlying acute lymphoblastic leukaemia. The other patient with post-bone marrow transplant chronic graft-versus-host disease and bronhioltis obliterans went into respiratory failure. Genetic analysis revealed that these cases were caused by different genetic variants which are circulating in poultry in this region. Review of literature identified another 9 human cases reported in Southern China since 1988. It is possible that human infection with H9N2 is more common than what has been recognized. Continuous surveillance of H9N2 influenza virus infection in human is warranted. © 2011 The British Infection Society.
 
ISSN0163-4453
2013 Impact Factor: 4.017
2013 SCImago Journal Rankings: 1.738
 
DOIhttp://dx.doi.org/10.1016/j.jinf.2011.02.007
 
ISI Accession Number IDWOS:000290790800009
Funding AgencyGrant Number
Providence Foundation Limited
Research Fund for the Control of Infectious Diseases (RFCID) of the Food and Health Bureau and Research Grants Council of the Hong Kong Special Administrative Region, ChinaHKU 7488/05M
7500/06M
HKU 7619/07M
Funding Information:

The study is partly funded by the Providence Foundation Limited in memory of the late Dr. Lui Hac Minh and the Research Fund for the Control of Infectious Diseases (RFCID) of the Food and Health Bureau and Research Grants Council of the Hong Kong Special Administrative Region, China (HKU 7488/05M, 7500/06M and HKU 7619/07M).

 
ReferencesReferences in Scopus
 
GrantsMolecular basis of genesis and determinants for pathogenicity of avian influenza H5N1 virus genotype Z
 
DC FieldValue
dc.contributor.authorCheng, VCC
 
dc.contributor.authorChan, JFW
 
dc.contributor.authorWen, X
 
dc.contributor.authorWu, WL
 
dc.contributor.authorQue, TL
 
dc.contributor.authorChen, H
 
dc.contributor.authorChan, KH
 
dc.contributor.authorYuen, KY
 
dc.date.accessioned2011-10-28T02:45:37Z
 
dc.date.available2011-10-28T02:45:37Z
 
dc.date.issued2011
 
dc.description.abstractAvian influenza A (H9N2) virus is transmitted sporadically from avian species to human causing mild diseases in immunocompetent person. We report two cases of human infection in immunocompromised patients in Hong Kong between 2008 and 2009. One patient had uneventful recovery with viral shedding at day 10 after symptom onset despite her underlying acute lymphoblastic leukaemia. The other patient with post-bone marrow transplant chronic graft-versus-host disease and bronhioltis obliterans went into respiratory failure. Genetic analysis revealed that these cases were caused by different genetic variants which are circulating in poultry in this region. Review of literature identified another 9 human cases reported in Southern China since 1988. It is possible that human infection with H9N2 is more common than what has been recognized. Continuous surveillance of H9N2 influenza virus infection in human is warranted. © 2011 The British Infection Society.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Infection, 2011, v. 62 n. 5, p. 394-399 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jinf.2011.02.007
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.jinf.2011.02.007
 
dc.identifier.epage399
 
dc.identifier.hkuros197228
 
dc.identifier.isiWOS:000290790800009
Funding AgencyGrant Number
Providence Foundation Limited
Research Fund for the Control of Infectious Diseases (RFCID) of the Food and Health Bureau and Research Grants Council of the Hong Kong Special Administrative Region, ChinaHKU 7488/05M
7500/06M
HKU 7619/07M
Funding Information:

The study is partly funded by the Providence Foundation Limited in memory of the late Dr. Lui Hac Minh and the Research Fund for the Control of Infectious Diseases (RFCID) of the Food and Health Bureau and Research Grants Council of the Hong Kong Special Administrative Region, China (HKU 7488/05M, 7500/06M and HKU 7619/07M).

 
dc.identifier.issn0163-4453
2013 Impact Factor: 4.017
2013 SCImago Journal Rankings: 1.738
 
dc.identifier.issue5
 
dc.identifier.pmid21356238
 
dc.identifier.scopuseid_2-s2.0-79956105325
 
dc.identifier.spage394
 
dc.identifier.urihttp://hdl.handle.net/10722/142419
 
dc.identifier.volume62
 
dc.languageeng
 
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinf
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofJournal of Infection
 
dc.relation.projectMolecular basis of genesis and determinants for pathogenicity of avian influenza H5N1 virus genotype Z
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshBone Marrow Transplantation - adverse effects
 
dc.subject.meshImmunocompromised Host
 
dc.subject.meshInfluenza A Virus, H9N2 Subtype - classification - genetics - isolation and purification
 
dc.subject.meshInfluenza, Human - complications - diagnosis - pathology - virology
 
dc.subject.meshRespiratory Insufficiency - diagnosis - etiology
 
dc.subjectAvian influenza A H9N2
 
dc.subjectBone marrow transplantation
 
dc.subjectImmunocompromised host
 
dc.titleInfection of immunocompromised patients by avian H9N2 influenza A virus
 
dc.typeArticle
 
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<contributor.author>Que, TL</contributor.author>
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Author Affiliations
  1. The University of Hong Kong
  2. Tuen Mun Hospital
  3. Queen Mary Hospital Hong Kong