Article: Infection of immunocompromised patients by avian H9N2 influenza A virus
| Title | Infection of immunocompromised patients by avian H9N2 influenza A virus | ||||||
|---|---|---|---|---|---|---|---|
| Authors | Cheng, VCC Chan, JFW Wen, X Wu, WL Que, TL Chen, H Chan, KH Yuen, KY | ||||||
| Keywords | Avian influenza A H9N2 Bone marrow transplantation Immunocompromised host | ||||||
| Issue Date | 2011 | ||||||
| Publisher | WB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinf | ||||||
| Citation | Journal Of Infection, 2011, v. 62 n. 5, p. 394-399 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.jinf.2011.02.007 | ||||||
| Abstract | Avian influenza A (H9N2) virus is transmitted sporadically from avian species to human causing mild diseases in immunocompetent person. We report two cases of human infection in immunocompromised patients in Hong Kong between 2008 and 2009. One patient had uneventful recovery with viral shedding at day 10 after symptom onset despite her underlying acute lymphoblastic leukaemia. The other patient with post-bone marrow transplant chronic graft-versus-host disease and bronhioltis obliterans went into respiratory failure. Genetic analysis revealed that these cases were caused by different genetic variants which are circulating in poultry in this region. Review of literature identified another 9 human cases reported in Southern China since 1988. It is possible that human infection with H9N2 is more common than what has been recognized. Continuous surveillance of H9N2 influenza virus infection in human is warranted. © 2011 The British Infection Society. | ||||||
| ISSN | 0163-4453 2011 Impact Factor: 4.126 2011 SCImago Journal Rankings: 0.293 | ||||||
| DOI | http://dx.doi.org/10.1016/j.jinf.2011.02.007 | ||||||
| ISI Accession Number ID | WOS:000290790800009
Funding Information: The study is partly funded by the Providence Foundation Limited in memory of the late Dr. Lui Hac Minh and the Research Fund for the Control of Infectious Diseases (RFCID) of the Food and Health Bureau and Research Grants Council of the Hong Kong Special Administrative Region, China (HKU 7488/05M, 7500/06M and HKU 7619/07M). | ||||||
| References | References in Scopus | ||||||
| Grants | Molecular basis of genesis and determinants for pathogenicity of avian influenza H5N1 virus genotype Z Molecular basis of genesis and determinants for pathogenicity of avian influenza H5N1 virus genotype Z |
| dc.contributor.author | Cheng, VCC | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Chan, JFW | ||||||
| dc.contributor.author | Wen, X | ||||||
| dc.contributor.author | Wu, WL | ||||||
| dc.contributor.author | Que, TL | ||||||
| dc.contributor.author | Chen, H | ||||||
| dc.contributor.author | Chan, KH | ||||||
| dc.contributor.author | Yuen, KY | ||||||
| dc.date.accessioned | 2011-10-28T02:45:37Z | ||||||
| dc.date.available | 2011-10-28T02:45:37Z | ||||||
| dc.date.issued | 2011 | ||||||
| dc.description.abstract | Avian influenza A (H9N2) virus is transmitted sporadically from avian species to human causing mild diseases in immunocompetent person. We report two cases of human infection in immunocompromised patients in Hong Kong between 2008 and 2009. One patient had uneventful recovery with viral shedding at day 10 after symptom onset despite her underlying acute lymphoblastic leukaemia. The other patient with post-bone marrow transplant chronic graft-versus-host disease and bronhioltis obliterans went into respiratory failure. Genetic analysis revealed that these cases were caused by different genetic variants which are circulating in poultry in this region. Review of literature identified another 9 human cases reported in Southern China since 1988. It is possible that human infection with H9N2 is more common than what has been recognized. Continuous surveillance of H9N2 influenza virus infection in human is warranted. © 2011 The British Infection Society. | ||||||
| dc.description.grant | Molecular basis of genesis and determinants for pathogenicity of avian influenza H5N1 virus genotype Z | ||||||
| dc.description.grant | Molecular basis of genesis and determinants for pathogenicity of avian influenza H5N1 virus genotype Z | ||||||
| dc.description.grantcode | 28113 | ||||||
| dc.description.grantcode | 29631 | ||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||
| dc.identifier.citation | Journal Of Infection, 2011, v. 62 n. 5, p. 394-399 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.jinf.2011.02.007 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1016/j.jinf.2011.02.007 | ||||||
| dc.identifier.epage | 399 | ||||||
| dc.identifier.hkuros | 197228 | ||||||
| dc.identifier.isi | WOS:000290790800009
Funding Information: The study is partly funded by the Providence Foundation Limited in memory of the late Dr. Lui Hac Minh and the Research Fund for the Control of Infectious Diseases (RFCID) of the Food and Health Bureau and Research Grants Council of the Hong Kong Special Administrative Region, China (HKU 7488/05M, 7500/06M and HKU 7619/07M). | ||||||
| dc.identifier.issn | 0163-4453 2011 Impact Factor: 4.126 2011 SCImago Journal Rankings: 0.293 | ||||||
| dc.identifier.issue | 5 | ||||||
| dc.identifier.pmid | 21356238 | ||||||
| dc.identifier.scopus | eid_2-s2.0-79956105325 | ||||||
| dc.identifier.spage | 394 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/142419 | ||||||
| dc.identifier.volume | 62 | ||||||
| dc.language | eng | ||||||
| dc.publisher | WB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinf | ||||||
| dc.publisher.place | United Kingdom | ||||||
| dc.relation.ispartof | Journal of Infection | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.subject.mesh | Bone Marrow Transplantation - adverse effects | ||||||
| dc.subject.mesh | Immunocompromised Host | ||||||
| dc.subject.mesh | Influenza A Virus, H9N2 Subtype - classification - genetics - isolation and purification | ||||||
| dc.subject.mesh | Influenza, Human - complications - diagnosis - pathology - virology | ||||||
| dc.subject.mesh | Respiratory Insufficiency - diagnosis - etiology | ||||||
| dc.subject | Avian influenza A H9N2 | ||||||
| dc.subject | Bone marrow transplantation | ||||||
| dc.subject | Immunocompromised host | ||||||
| dc.title | Infection of immunocompromised patients by avian H9N2 influenza A virus | ||||||
| dc.type | Article |
Author Affiliations
- Tuen Mun Hospital
- The University of Hong Kong
- Queen Mary Hospital Hong Kong