Article: Serological survey of antibodies to influenza A viruses in a group of people without a history of influenza vaccination
| Title | Serological survey of antibodies to influenza A viruses in a group of people without a history of influenza vaccination | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Authors | Chen, Y1 Zheng, Q1 Yang, K3 Zeng, F1 Lau, SY2 Wu, WL2 Huang, S1 Zhang, J1 Chen, H2 Xia, N1 | ||||||||||||||
| Issue Date | 2011 | ||||||||||||||
| Publisher | 3Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLM | ||||||||||||||
| Citation | Clinical Microbiology and Infection, 2011, v. 17 n. 9, p. 1347-1349 [How to Cite?] DOI: http://dx.doi.org/10.1111/j.1469-0691.2011.03538.x | ||||||||||||||
| Abstract | A serological survey for antibodies to influenza viruses was performed in China on a group of people without a history of influenza vaccination. Using the haemagglutination inhibition (HI) assay, we found seropositivity rates for seasonal H3N2 to be significantly higher than those for seasonal H1N1. Samples positive for antibodies to the pandemic (H1N1) 2009 virus increased from 0.6% pre-outbreak to 4.5% (p <0.01) at 1 year post-outbreak. Interestingly, HI and neutralization tests showed that 1.4% of people in the group have antibodies recognizing H9N2 avian influenza viruses, suggesting that infection with this subtype may be more common than previously thought. | ||||||||||||||
| ISSN | 1198-743X 2011 Impact Factor: 4.54 2011 SCImago Journal Rankings: 0.320 | ||||||||||||||
| DOI | http://dx.doi.org/10.1111/j.1469-0691.2011.03538.x | ||||||||||||||
| ISI Accession Number ID | WOS:000294125000010
Funding Information: We thank Feng-Cai Zhu from Jiangsu CDC and Zhong-Ze Wang from Dongtai CDC in Jiangsu, China for their help in this study. This work was supported by grants from the National Natural Science Foundation of China (30901077), the Key Project of the National 863 Program of China (2010AA022801), the Natural Science Foundation of Fujian Province in China (2010J05083), the Areas of Excellence Scheme of the University Grants Committee (AoE/M-12/06), the National Institutes of Health (NIAID contract HHSN2662007 00005C) and the Research Fund for the Control of Infectious Diseases, Hong Kong SAR, China. | ||||||||||||||
| PubMed Central ID | PMC3166400 | ||||||||||||||
| References | References in Scopus | ||||||||||||||
| Grants | Control of Pandemic and Inter-pandemic Influenza |
| dc.contributor.author | Chen, Y | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dc.contributor.author | Zheng, Q | ||||||||||||||
| dc.contributor.author | Yang, K | ||||||||||||||
| dc.contributor.author | Zeng, F | ||||||||||||||
| dc.contributor.author | Lau, SY | ||||||||||||||
| dc.contributor.author | Wu, WL | ||||||||||||||
| dc.contributor.author | Huang, S | ||||||||||||||
| dc.contributor.author | Zhang, J | ||||||||||||||
| dc.contributor.author | Chen, H | ||||||||||||||
| dc.contributor.author | Xia, N | ||||||||||||||
| dc.date.accessioned | 2011-10-28T02:45:34Z | ||||||||||||||
| dc.date.available | 2011-10-28T02:45:34Z | ||||||||||||||
| dc.date.issued | 2011 | ||||||||||||||
| dc.description.abstract | A serological survey for antibodies to influenza viruses was performed in China on a group of people without a history of influenza vaccination. Using the haemagglutination inhibition (HI) assay, we found seropositivity rates for seasonal H3N2 to be significantly higher than those for seasonal H1N1. Samples positive for antibodies to the pandemic (H1N1) 2009 virus increased from 0.6% pre-outbreak to 4.5% (p <0.01) at 1 year post-outbreak. Interestingly, HI and neutralization tests showed that 1.4% of people in the group have antibodies recognizing H9N2 avian influenza viruses, suggesting that infection with this subtype may be more common than previously thought. | ||||||||||||||
| dc.description.grant | Control of Pandemic and Inter-pandemic Influenza | ||||||||||||||
| dc.description.grantcode | 97655 | ||||||||||||||
| dc.description.nature | link_to_OA_fulltext | ||||||||||||||
| dc.identifier.citation | Clinical Microbiology and Infection, 2011, v. 17 n. 9, p. 1347-1349 [How to Cite?] DOI: http://dx.doi.org/10.1111/j.1469-0691.2011.03538.x | ||||||||||||||
| dc.identifier.citeulike | 9719451 | ||||||||||||||
| dc.identifier.doi | http://dx.doi.org/10.1111/j.1469-0691.2011.03538.x | ||||||||||||||
| dc.identifier.epage | 1349 | ||||||||||||||
| dc.identifier.hkuros | 197176 | ||||||||||||||
| dc.identifier.isi | WOS:000294125000010
Funding Information: We thank Feng-Cai Zhu from Jiangsu CDC and Zhong-Ze Wang from Dongtai CDC in Jiangsu, China for their help in this study. This work was supported by grants from the National Natural Science Foundation of China (30901077), the Key Project of the National 863 Program of China (2010AA022801), the Natural Science Foundation of Fujian Province in China (2010J05083), the Areas of Excellence Scheme of the University Grants Committee (AoE/M-12/06), the National Institutes of Health (NIAID contract HHSN2662007 00005C) and the Research Fund for the Control of Infectious Diseases, Hong Kong SAR, China. | ||||||||||||||
| dc.identifier.issn | 1198-743X 2011 Impact Factor: 4.54 2011 SCImago Journal Rankings: 0.320 | ||||||||||||||
| dc.identifier.issue | 9 | ||||||||||||||
| dc.identifier.pmcid | PMC3166400 | ||||||||||||||
| dc.identifier.pmid | 21749549 | ||||||||||||||
| dc.identifier.scopus | eid_2-s2.0-80051877111 | ||||||||||||||
| dc.identifier.spage | 1347 | ||||||||||||||
| dc.identifier.uri | http://hdl.handle.net/10722/142416 | ||||||||||||||
| dc.identifier.volume | 17 | ||||||||||||||
| dc.language | eng | ||||||||||||||
| dc.publisher | 3Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLM | ||||||||||||||
| dc.publisher.place | United Kingdom | ||||||||||||||
| dc.relation.ispartof | Clinical Microbiology and Infection | ||||||||||||||
| dc.relation.references | References in Scopus | ||||||||||||||
| dc.subject.mesh | Antibodies, Viral - blood | ||||||||||||||
| dc.subject.mesh | Influenza A Virus, H1N1 Subtype - immunology | ||||||||||||||
| dc.subject.mesh | Influenza A Virus, H3N2 Subtype - immunology | ||||||||||||||
| dc.subject.mesh | Influenza A virus - classification - immunology | ||||||||||||||
| dc.subject.mesh | Influenza, Human - epidemiology - immunology - virology | ||||||||||||||
| dc.title | Serological survey of antibodies to influenza A viruses in a group of people without a history of influenza vaccination | ||||||||||||||
| dc.type | Article |
Author Affiliations
- Xiamen University
- The University of Hong Kong
- Xiamen International Travel Health Care Centre