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Article: Serological survey of antibodies to influenza A viruses in a group of people without a history of influenza vaccination
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TitleSerological survey of antibodies to influenza A viruses in a group of people without a history of influenza vaccination
 
AuthorsChen, Y1
Zheng, Q1
Yang, K3
Zeng, F1
Lau, SY2
Wu, WL2
Huang, S1
Zhang, J1
Chen, H2
Xia, N1
 
Issue Date2011
 
Publisher3Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLM
 
CitationClinical Microbiology and Infection, 2011, v. 17 n. 9, p. 1347-1349 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1469-0691.2011.03538.x
 
AbstractA serological survey for antibodies to influenza viruses was performed in China on a group of people without a history of influenza vaccination. Using the haemagglutination inhibition (HI) assay, we found seropositivity rates for seasonal H3N2 to be significantly higher than those for seasonal H1N1. Samples positive for antibodies to the pandemic (H1N1) 2009 virus increased from 0.6% pre-outbreak to 4.5% (p <0.01) at 1 year post-outbreak. Interestingly, HI and neutralization tests showed that 1.4% of people in the group have antibodies recognizing H9N2 avian influenza viruses, suggesting that infection with this subtype may be more common than previously thought.
 
ISSN1198-743X
2012 Impact Factor: 4.578
2012 SCImago Journal Rankings: 1.550
 
DOIhttp://dx.doi.org/10.1111/j.1469-0691.2011.03538.x
 
PubMed Central IDPMC3166400
 
ISI Accession Number IDWOS:000294125000010
Funding AgencyGrant Number
National Natural Science Foundation of China30901077
Key Project of the National 863 Program of China2010AA022801
Natural Science Foundation of Fujian Province in China2010J05083
University Grants CommitteeAoE/M-12/06
National Institutes of Health (NIAID)HHSN2662007 00005C
Research Fund for the Control of Infectious Diseases, Hong Kong SAR, China
Funding Information:

We thank Feng-Cai Zhu from Jiangsu CDC and Zhong-Ze Wang from Dongtai CDC in Jiangsu, China for their help in this study. This work was supported by grants from the National Natural Science Foundation of China (30901077), the Key Project of the National 863 Program of China (2010AA022801), the Natural Science Foundation of Fujian Province in China (2010J05083), the Areas of Excellence Scheme of the University Grants Committee (AoE/M-12/06), the National Institutes of Health (NIAID contract HHSN2662007 00005C) and the Research Fund for the Control of Infectious Diseases, Hong Kong SAR, China.

 
ReferencesReferences in Scopus
 
GrantsControl of Pandemic and Inter-pandemic Influenza
 
DC FieldValue
dc.contributor.authorChen, Y
 
dc.contributor.authorZheng, Q
 
dc.contributor.authorYang, K
 
dc.contributor.authorZeng, F
 
dc.contributor.authorLau, SY
 
dc.contributor.authorWu, WL
 
dc.contributor.authorHuang, S
 
dc.contributor.authorZhang, J
 
dc.contributor.authorChen, H
 
dc.contributor.authorXia, N
 
dc.date.accessioned2011-10-28T02:45:34Z
 
dc.date.available2011-10-28T02:45:34Z
 
dc.date.issued2011
 
dc.description.abstractA serological survey for antibodies to influenza viruses was performed in China on a group of people without a history of influenza vaccination. Using the haemagglutination inhibition (HI) assay, we found seropositivity rates for seasonal H3N2 to be significantly higher than those for seasonal H1N1. Samples positive for antibodies to the pandemic (H1N1) 2009 virus increased from 0.6% pre-outbreak to 4.5% (p <0.01) at 1 year post-outbreak. Interestingly, HI and neutralization tests showed that 1.4% of people in the group have antibodies recognizing H9N2 avian influenza viruses, suggesting that infection with this subtype may be more common than previously thought.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationClinical Microbiology and Infection, 2011, v. 17 n. 9, p. 1347-1349 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1469-0691.2011.03538.x
 
dc.identifier.citeulike9719451
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1469-0691.2011.03538.x
 
dc.identifier.epage1349
 
dc.identifier.hkuros197176
 
dc.identifier.isiWOS:000294125000010
Funding AgencyGrant Number
National Natural Science Foundation of China30901077
Key Project of the National 863 Program of China2010AA022801
Natural Science Foundation of Fujian Province in China2010J05083
University Grants CommitteeAoE/M-12/06
National Institutes of Health (NIAID)HHSN2662007 00005C
Research Fund for the Control of Infectious Diseases, Hong Kong SAR, China
Funding Information:

We thank Feng-Cai Zhu from Jiangsu CDC and Zhong-Ze Wang from Dongtai CDC in Jiangsu, China for their help in this study. This work was supported by grants from the National Natural Science Foundation of China (30901077), the Key Project of the National 863 Program of China (2010AA022801), the Natural Science Foundation of Fujian Province in China (2010J05083), the Areas of Excellence Scheme of the University Grants Committee (AoE/M-12/06), the National Institutes of Health (NIAID contract HHSN2662007 00005C) and the Research Fund for the Control of Infectious Diseases, Hong Kong SAR, China.

 
dc.identifier.issn1198-743X
2012 Impact Factor: 4.578
2012 SCImago Journal Rankings: 1.550
 
dc.identifier.issue9
 
dc.identifier.pmcidPMC3166400
 
dc.identifier.pmid21749549
 
dc.identifier.scopuseid_2-s2.0-80051877111
 
dc.identifier.spage1347
 
dc.identifier.urihttp://hdl.handle.net/10722/142416
 
dc.identifier.volume17
 
dc.languageeng
 
dc.publisher3Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLM
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofClinical Microbiology and Infection
 
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAntibodies, Viral - blood
 
dc.subject.meshInfluenza A Virus, H1N1 Subtype - immunology
 
dc.subject.meshInfluenza A Virus, H3N2 Subtype - immunology
 
dc.subject.meshInfluenza A virus - classification - immunology
 
dc.subject.meshInfluenza, Human - epidemiology - immunology - virology
 
dc.titleSerological survey of antibodies to influenza A viruses in a group of people without a history of influenza vaccination
 
dc.typeArticle
 
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<contributor.author>Wu, WL</contributor.author>
<contributor.author>Huang, S</contributor.author>
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Author Affiliations
  1. Xiamen University
  2. The University of Hong Kong
  3. Xiamen International Travel Health Care Centre