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Article: Gentamicin-loaded strontium-containing hydroxyapatite bioactive bone cement-An efficient bioactive antibiotic drug delivery system

TitleGentamicin-loaded strontium-containing hydroxyapatite bioactive bone cement-An efficient bioactive antibiotic drug delivery system
Authors
Keywordsantimicrobial
bioactive material
bone cement
mechanical properties
strontium-containing hydroxyapatite
Issue Date2010
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/
Citation
Journal Of Biomedical Materials Research - Part B Applied Biomaterials, 2010, v. 95 B n. 2, p. 397-406 How to Cite?
AbstractModified strontium-containing hydroxyapatite (Sr-HA) bone cement was loaded with gentamicin sulfate to generate an efficient bioactive antibiotic drug delivery system for treatment of bone defects. Gentamicin release and its antibacterial property were determined by fluorometric method and inhibition of Staphylococcus aureus (S. aureus) growth. Gentamicin was released from Sr-HA bone cement during the entire period of study and reached around 38% (w/w) cumulatively after 30 days. Antibacterial activity of the gentamicin loaded in the cements is clearly confirmed by the growth inhibition of S. aureus. The results of the amount and duration of gentamicin release suggest a better drug delivery efficiency in Sr-HA bone cement over polymethylmethacrylate bone cement. Bioactivity of the gentamicin-loaded Sr-HA bone cement was confirmed with the formation of apatite layer with 1.836 ± 0.037 μm thick on day 1 and 5.177 ± 1.355 μm thick on day 7 after immersion in simulated body fluid. Compressive strengths of the gentamicin-loaded Sr-HA cement reached 132.60 ± 10.08 MPa, with a slight decrease from the unloaded groups by 4-9%. Bending moduli of Sr-HA cements with and without gentamicin were 1.782 ± 0.072 GPa and 1.681 ± 0.208 GPa, respectively. On the contrary, unloaded Sr-HA cement obtained slightly larger bending strength of 35.48 ± 2.63 MPa comparing with 33.00 ± 1.65 MPa for loaded cement. No statistical difference was found on the bending strengths and modulus of gentamicin-loaded and -unloaded Sr-HA cements. Sr-HA bone cement loaded with gentamicin was proven to be an efficient drug delivery system with uncompromised mechanical properties and bioactivity. © 2010 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/142415
ISSN
2015 Impact Factor: 2.881
2015 SCImago Journal Rankings: 0.784
ISI Accession Number ID
Funding AgencyGrant Number
ITC, Hong Kong Government
RGC, Hong Kong Government
Funding Information:

Contract grant sponsors: ITC and RGC, Hong Kong Government

References

 

DC FieldValueLanguage
dc.contributor.authorLiu, WCen_HK
dc.contributor.authorWong, CTen_HK
dc.contributor.authorFong, MKen_HK
dc.contributor.authorCheung, WSen_HK
dc.contributor.authorKao, RYTen_HK
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorLu, WWen_HK
dc.date.accessioned2011-10-28T02:45:32Z-
dc.date.available2011-10-28T02:45:32Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Biomedical Materials Research - Part B Applied Biomaterials, 2010, v. 95 B n. 2, p. 397-406en_HK
dc.identifier.issn1552-4973en_HK
dc.identifier.urihttp://hdl.handle.net/10722/142415-
dc.description.abstractModified strontium-containing hydroxyapatite (Sr-HA) bone cement was loaded with gentamicin sulfate to generate an efficient bioactive antibiotic drug delivery system for treatment of bone defects. Gentamicin release and its antibacterial property were determined by fluorometric method and inhibition of Staphylococcus aureus (S. aureus) growth. Gentamicin was released from Sr-HA bone cement during the entire period of study and reached around 38% (w/w) cumulatively after 30 days. Antibacterial activity of the gentamicin loaded in the cements is clearly confirmed by the growth inhibition of S. aureus. The results of the amount and duration of gentamicin release suggest a better drug delivery efficiency in Sr-HA bone cement over polymethylmethacrylate bone cement. Bioactivity of the gentamicin-loaded Sr-HA bone cement was confirmed with the formation of apatite layer with 1.836 ± 0.037 μm thick on day 1 and 5.177 ± 1.355 μm thick on day 7 after immersion in simulated body fluid. Compressive strengths of the gentamicin-loaded Sr-HA cement reached 132.60 ± 10.08 MPa, with a slight decrease from the unloaded groups by 4-9%. Bending moduli of Sr-HA cements with and without gentamicin were 1.782 ± 0.072 GPa and 1.681 ± 0.208 GPa, respectively. On the contrary, unloaded Sr-HA cement obtained slightly larger bending strength of 35.48 ± 2.63 MPa comparing with 33.00 ± 1.65 MPa for loaded cement. No statistical difference was found on the bending strengths and modulus of gentamicin-loaded and -unloaded Sr-HA cements. Sr-HA bone cement loaded with gentamicin was proven to be an efficient drug delivery system with uncompromised mechanical properties and bioactivity. © 2010 Wiley Periodicals, Inc.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/en_HK
dc.relation.ispartofJournal of Biomedical Materials Research - Part B Applied Biomaterialsen_HK
dc.rightsJournal of Biomedical Materials Research Part B: Applied Biomaterials. Copyright © John Wiley & Sons, Inc.-
dc.subjectantimicrobialen_HK
dc.subjectbioactive materialen_HK
dc.subjectbone cementen_HK
dc.subjectmechanical propertiesen_HK
dc.subjectstrontium-containing hydroxyapatiteen_HK
dc.subject.meshAnti-Bacterial Agents - administration and dosage - pharmacology-
dc.subject.meshBiocompatible Materials-
dc.subject.meshBone Cements-
dc.subject.meshDurapatite-
dc.subject.meshGentamicins - administration and dosage - pharmacology-
dc.titleGentamicin-loaded strontium-containing hydroxyapatite bioactive bone cement-An efficient bioactive antibiotic drug delivery systemen_HK
dc.typeArticleen_HK
dc.identifier.emailKao, RYT:rytkao@hkucc.hku.hken_HK
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_HK
dc.identifier.emailLu, WW:wwlu@hku.hken_HK
dc.identifier.authorityKao, RYT=rp00481en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jbm.b.31730en_HK
dc.identifier.pmid20878924-
dc.identifier.scopuseid_2-s2.0-78649660297en_HK
dc.identifier.hkuros196989en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78649660297&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume95 Ben_HK
dc.identifier.issue2en_HK
dc.identifier.spage397en_HK
dc.identifier.epage406en_HK
dc.identifier.isiWOS:000283103400019-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiu, WC=26656769100en_HK
dc.identifier.scopusauthoridWong, CT=7404954512en_HK
dc.identifier.scopusauthoridFong, MK=26538502500en_HK
dc.identifier.scopusauthoridCheung, WS=36655523900en_HK
dc.identifier.scopusauthoridKao, RYT=7101675499en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK

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