File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Location-specific patterns of exposure to recent pre-pandemic strains of influenza A in southern China

TitleLocation-specific patterns of exposure to recent pre-pandemic strains of influenza A in southern China
Authors
Issue Date2011
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ncomms/index.html
Citation
Nature Communications, 2011, v. 2, article no. 423 How to Cite?
AbstractVariation in influenza incidence between locations is commonly observed on large spatial scales. It is unclear whether such variation occurs on smaller spatial scales and whether it is the result of heterogeneities in population demographics or more subtle differences in population structure and connectivity. Here we show that significant differences in immunity to influenza A viruses among communities in China are not explained by differences in population demographics. We randomly selected households from five randomly selected locations near Guangzhou, China to answer a questionnaire and provide a blood sample for serological testing against five recently circulating influenza viruses. We find a significant reduction in the frequency of detectable neutralization titers with increasing age, levelling off in older age groups. There are significant differences between locations in age, employment status, vaccination history, household size and housing conditions. However, after adjustment, significant variations in the frequency of detectable neutralization titers persists between locations. These results suggest there are characteristics of communities that drive influenza transmission dynamics apart from individual and household level risk factors, and that such factors have effects independent of strain. © 2011 Macmillan Publishers Limited. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/142406
ISSN
2015 Impact Factor: 11.329
2015 SCImago Journal Rankings: 6.539
ISI Accession Number ID
Funding AgencyGrant Number
National Institutes of Health Fogarty Institute1 R01 TW 0008246-01
Burroughs Wellcome Fund
University Grants CommitteeAoE/M-12/06
Funding Information:

This study was supported by a grant from the National Institutes of Health Fogarty Institute (1 R01 TW 0008246-01). The authors thank the dedicated study staff at Guangzhou No. 12 Hospital and the participants of the study, without whom this research would not have been possible. D. A. T. C. is supported by a Career Award at the Scientific Interface from the Burroughs Wellcome Fund. Y.G. was supported by the Area of Excellence Scheme of the University Grants Committee (grant AoE/M-12/06).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorLessler, Jen_HK
dc.contributor.authorCummings, DATen_HK
dc.contributor.authorRead, JMen_HK
dc.contributor.authorWang, Sen_HK
dc.contributor.authorZhu, Hen_HK
dc.contributor.authorSmith, GJDen_HK
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorJiang, CQen_HK
dc.contributor.authorRiley, Sen_HK
dc.date.accessioned2011-10-28T02:45:24Z-
dc.date.available2011-10-28T02:45:24Z-
dc.date.issued2011en_HK
dc.identifier.citationNature Communications, 2011, v. 2, article no. 423en_HK
dc.identifier.issn2041-1723en_HK
dc.identifier.urihttp://hdl.handle.net/10722/142406-
dc.description.abstractVariation in influenza incidence between locations is commonly observed on large spatial scales. It is unclear whether such variation occurs on smaller spatial scales and whether it is the result of heterogeneities in population demographics or more subtle differences in population structure and connectivity. Here we show that significant differences in immunity to influenza A viruses among communities in China are not explained by differences in population demographics. We randomly selected households from five randomly selected locations near Guangzhou, China to answer a questionnaire and provide a blood sample for serological testing against five recently circulating influenza viruses. We find a significant reduction in the frequency of detectable neutralization titers with increasing age, levelling off in older age groups. There are significant differences between locations in age, employment status, vaccination history, household size and housing conditions. However, after adjustment, significant variations in the frequency of detectable neutralization titers persists between locations. These results suggest there are characteristics of communities that drive influenza transmission dynamics apart from individual and household level risk factors, and that such factors have effects independent of strain. © 2011 Macmillan Publishers Limited. All rights reserved.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ncomms/index.htmlen_HK
dc.relation.ispartofNature Communicationsen_HK
dc.subject.meshChina - epidemiology-
dc.subject.meshInfluenza A virus - classification - genetics - immunology - isolation and purification-
dc.subject.meshInfluenza, Human - epidemiology - immunology - transmission-
dc.subject.meshPandemics-
dc.subject.meshPhylogeny-
dc.titleLocation-specific patterns of exposure to recent pre-pandemic strains of influenza A in southern Chinaen_HK
dc.typeArticleen_HK
dc.identifier.emailZhu, H: zhuhch@hku.hken_HK
dc.identifier.emailSmith, GJD: gjsmith@hkucc1.hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.emailRiley, S: steven.riley@hku.hken_HK
dc.identifier.authorityZhu, H=rp01535en_HK
dc.identifier.authoritySmith, GJD=rp00444en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.identifier.authorityRiley, S=rp00511en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ncomms1432en_HK
dc.identifier.pmid21829185-
dc.identifier.scopuseid_2-s2.0-80052465185en_HK
dc.identifier.hkuros196753en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052465185&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume2en_HK
dc.identifier.isiWOS:000294806500016-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridLessler, J=22951309100en_HK
dc.identifier.scopusauthoridCummings, DAT=9842706300en_HK
dc.identifier.scopusauthoridRead, JM=36761595400en_HK
dc.identifier.scopusauthoridWang, S=51261625200en_HK
dc.identifier.scopusauthoridZhu, H=25724029300en_HK
dc.identifier.scopusauthoridSmith, GJD=8344015800en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.scopusauthoridJiang, CQ=10639500500en_HK
dc.identifier.scopusauthoridRiley, S=7102619416en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats