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Article: Reassortment events among swine influenza a viruses in China: Implications for the origin of the 2009 influenza pandemic

TitleReassortment events among swine influenza a viruses in China: Implications for the origin of the 2009 influenza pandemic
Authors
Issue Date2011
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2011, v. 85 n. 19, p. 10279-10285 How to Cite?
AbstractThat pigs may play a pivotal role in the emergence of pandemic influenza was indicated by the recent H1N1/2009 human pandemic, likely caused by a reassortant between viruses of the American triple-reassortant (TR) and Eurasian avian-like (EA) swine influenza lineages. As China has the largest human and pig populations in the world and is the only place where both TR and EA viruses have been reported to cocirculate, it is potentially the source of the H1N1/2009 pandemic virus. To examine this, the genome sequences of 405 swine influenza viruses from China were analyzed. Thirty-six TR and EA reassortant viruses were identified before and after the occurrence of the pandemic. Several of these TR-EA reassortant viruses had genotypes with most segments having the same lineage origin as the segments of the H1N1/2009 pandemic virus. However, these viruses were generated from independent reassortment events throughout our survey period and were not associated with the current pandemic. One TR-EA reassortant, which is least similar to the pandemic virus, has persisted since 2007, while all the other variants appear to be transient. Despite frequent reassortment events between TR and EA lineage viruses in China, evidence for the genesis of the 2009 pandemic virus in pigs in this region is still absent. © 2011, American Society for Microbiology.
Persistent Identifierhttp://hdl.handle.net/10722/142405
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
National Institutes of Health (National Institute of Allergy and Infectious Diseases)HSN266200700005C
Li Ka Shing Foundation
Area of Excellence Scheme of the UGC of the Hong Kong SARAoE/M-12/06
Computer Centre of The University of Hong Kong
Funding Information:

We acknowledge the National Institutes of Health (National Institute of Allergy and Infectious Diseases contract HSN266200700005C), the Li Ka Shing Foundation, and the Area of Excellence Scheme of the UGC of the Hong Kong SAR (grant AoE/M-12/06) for financial support.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorLam, TTen_HK
dc.contributor.authorZhu, Hen_HK
dc.contributor.authorWang, Jen_HK
dc.contributor.authorSmith, DKen_HK
dc.contributor.authorHolmes, ECen_HK
dc.contributor.authorWebster, RGen_HK
dc.contributor.authorWebby, Ren_HK
dc.contributor.authorPeiris, JMen_HK
dc.contributor.authorGuan, Yen_HK
dc.date.accessioned2011-10-28T02:45:23Z-
dc.date.available2011-10-28T02:45:23Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Virology, 2011, v. 85 n. 19, p. 10279-10285en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/142405-
dc.description.abstractThat pigs may play a pivotal role in the emergence of pandemic influenza was indicated by the recent H1N1/2009 human pandemic, likely caused by a reassortant between viruses of the American triple-reassortant (TR) and Eurasian avian-like (EA) swine influenza lineages. As China has the largest human and pig populations in the world and is the only place where both TR and EA viruses have been reported to cocirculate, it is potentially the source of the H1N1/2009 pandemic virus. To examine this, the genome sequences of 405 swine influenza viruses from China were analyzed. Thirty-six TR and EA reassortant viruses were identified before and after the occurrence of the pandemic. Several of these TR-EA reassortant viruses had genotypes with most segments having the same lineage origin as the segments of the H1N1/2009 pandemic virus. However, these viruses were generated from independent reassortment events throughout our survey period and were not associated with the current pandemic. One TR-EA reassortant, which is least similar to the pandemic virus, has persisted since 2007, while all the other variants appear to be transient. Despite frequent reassortment events between TR and EA lineage viruses in China, evidence for the genesis of the 2009 pandemic virus in pigs in this region is still absent. © 2011, American Society for Microbiology.en_HK
dc.languageengen_US
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.-
dc.rightsCopyright © American Society for Microbiology, [insert journal name, volume number, page numbers, and year]-
dc.subject.meshInfluenza A virus - genetics - isolation and purification-
dc.subject.meshOrthomyxoviridae Infections - veterinary - virology-
dc.subject.meshReassortant Viruses - genetics - isolation and purification-
dc.subject.meshRecombination, Genetic-
dc.subject.meshSwine Diseases - virology-
dc.titleReassortment events among swine influenza a viruses in China: Implications for the origin of the 2009 influenza pandemicen_HK
dc.typeArticleen_HK
dc.identifier.emailLam, TT: ttylam@hku.hken_HK
dc.identifier.emailZhu, H: zhuhch@hku.hken_HK
dc.identifier.emailPeiris, JM: malik@hkucc.hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.authorityLam, TT=rp01733en_HK
dc.identifier.authorityZhu, H=rp01535en_HK
dc.identifier.authorityPeiris, JM=rp00410en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1128/JVI.05262-11en_HK
dc.identifier.pmid21795347-
dc.identifier.pmcidPMC3196454-
dc.identifier.scopuseid_2-s2.0-80053947748en_HK
dc.identifier.hkuros196748en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80053947748&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume85en_HK
dc.identifier.issue19en_HK
dc.identifier.spage10279en_HK
dc.identifier.epage10285en_HK
dc.identifier.eissn1098-5514-
dc.identifier.isiWOS:000296253900060-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridLam, TT=36775821700en_HK
dc.identifier.scopusauthoridZhu, H=25724029300en_HK
dc.identifier.scopusauthoridWang, J=35228130300en_HK
dc.identifier.scopusauthoridSmith, DK=7410351143en_HK
dc.identifier.scopusauthoridHolmes, EC=35433598300en_HK
dc.identifier.scopusauthoridWebster, RG=36048363100en_HK
dc.identifier.scopusauthoridWebby, R=35448064800en_HK
dc.identifier.scopusauthoridPeiris, JM=7005486823en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK

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