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Article: In vivo retinotopic mapping of superior colliculus using manganese-enhanced magnetic resonance imaging

TitleIn vivo retinotopic mapping of superior colliculus using manganese-enhanced magnetic resonance imaging
Authors
KeywordsAnterograde axonal transport
Intraorbital optic nerve
Manganese-enhanced MRI
Partial transection
Retinotopic mapping
Superior colliculus
Issue Date2011
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
Citation
Neuroimage, 2011, v. 54 n. 1, p. 389-395 How to Cite?
AbstractThe superior colliculus (SC) is a dome-shaped subcortical laminar structure in the mammalian midbrain, whose superficial layers receive visual information from the retina in a topological order. Despite the increasing number of studies investigating retinotopic projection in visual brain development and disorders, in vivo, high-resolution 3D mapping of topographic organization in the subcortical visual nuclei has not yet been available. This study explores the capability of 3D manganese-enhanced MRI (MEMRI) at 200μm isotropic resolution for in vivo retinotopic mapping of the rat SC upon partial transection of the intraorbital optic nerve. One day after intravitreal Mn 2+ injection into both eyes, animals with partial transection at the right superior intraorbital optic nerve in Group 1 (n=8) exhibited a significantly lower T1-weighted signal intensity in the lateral region of the left SC compared to the left medial SC and right control SC. Partial transection toward the temporal or nasal region of the right intraorbital optic nerve in Group 2 (n=7) led to T1-weighted hypointensity in the rostral or caudal region of the left SC, whereas a clear border was observed separating 2 halves of the left SC in all groups. Previous histological and electrophysiological studies showed that the retinal ganglion cell axons emanating from superior, inferior, nasal and temporal retina projected respectively to the contralateral lateral, medial, caudal and rostral SC in rodents. While this topological pattern is preserved in the intraorbital optic nerve, it was shown that partial transection of the superior intraorbital optic nerve led to primary injury predominantly in the superior but not inferior retina and optic nerve. The results of this study demonstrated the sensitivity of submillimeter-resolution MEMRI for in vivo, 3D mapping of the precise retinotopic projections in SC upon reduced anterograde axonal transport of Mn 2+ ions from localized regions of the anterior visual pathways to the subcortical midbrain nuclei. Future MEMRI studies are envisioned that measure the topographic changes in brain development, diseases, plasticity and regeneration therapies in a global and longitudinal setting. © 2010 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/142313
ISSN
2014 Impact Factor: 6.357
2014 SCImago Journal Rankings: 3.549
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grant CouncilGRF HKU 7793/08 M
GRF HKU 7808/09 M
Funding Information:

This work was supported by the Hong Kong Research Grant Council (GRF HKU 7793/08 M and GRF HKU 7808/09 M).

References

 

DC FieldValueLanguage
dc.contributor.authorChan, KCen_HK
dc.contributor.authorLi, Jen_HK
dc.contributor.authorKau, Pen_HK
dc.contributor.authorZhou, IYen_HK
dc.contributor.authorCheung, MMen_HK
dc.contributor.authorLau, Cen_HK
dc.contributor.authorYang, Jen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2011-10-28T02:42:43Z-
dc.date.available2011-10-28T02:42:43Z-
dc.date.issued2011en_HK
dc.identifier.citationNeuroimage, 2011, v. 54 n. 1, p. 389-395en_HK
dc.identifier.issn1053-8119en_HK
dc.identifier.urihttp://hdl.handle.net/10722/142313-
dc.description.abstractThe superior colliculus (SC) is a dome-shaped subcortical laminar structure in the mammalian midbrain, whose superficial layers receive visual information from the retina in a topological order. Despite the increasing number of studies investigating retinotopic projection in visual brain development and disorders, in vivo, high-resolution 3D mapping of topographic organization in the subcortical visual nuclei has not yet been available. This study explores the capability of 3D manganese-enhanced MRI (MEMRI) at 200μm isotropic resolution for in vivo retinotopic mapping of the rat SC upon partial transection of the intraorbital optic nerve. One day after intravitreal Mn 2+ injection into both eyes, animals with partial transection at the right superior intraorbital optic nerve in Group 1 (n=8) exhibited a significantly lower T1-weighted signal intensity in the lateral region of the left SC compared to the left medial SC and right control SC. Partial transection toward the temporal or nasal region of the right intraorbital optic nerve in Group 2 (n=7) led to T1-weighted hypointensity in the rostral or caudal region of the left SC, whereas a clear border was observed separating 2 halves of the left SC in all groups. Previous histological and electrophysiological studies showed that the retinal ganglion cell axons emanating from superior, inferior, nasal and temporal retina projected respectively to the contralateral lateral, medial, caudal and rostral SC in rodents. While this topological pattern is preserved in the intraorbital optic nerve, it was shown that partial transection of the superior intraorbital optic nerve led to primary injury predominantly in the superior but not inferior retina and optic nerve. The results of this study demonstrated the sensitivity of submillimeter-resolution MEMRI for in vivo, 3D mapping of the precise retinotopic projections in SC upon reduced anterograde axonal transport of Mn 2+ ions from localized regions of the anterior visual pathways to the subcortical midbrain nuclei. Future MEMRI studies are envisioned that measure the topographic changes in brain development, diseases, plasticity and regeneration therapies in a global and longitudinal setting. © 2010 Elsevier Inc.en_HK
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimgen_HK
dc.relation.ispartofNeuroImageen_HK
dc.subjectAnterograde axonal transporten_HK
dc.subjectIntraorbital optic nerveen_HK
dc.subjectManganese-enhanced MRIen_HK
dc.subjectPartial transectionen_HK
dc.subjectRetinotopic mappingen_HK
dc.subjectSuperior colliculusen_HK
dc.subject.meshBrain Mapping - methods-
dc.subject.meshMagnetic Resonance Imaging - methods-
dc.subject.meshManganese - pharmacology-
dc.subject.meshOptic Nerve - anatomy and histology - physiology-
dc.subject.meshRetina - drug effects - physiology-
dc.titleIn vivo retinotopic mapping of superior colliculus using manganese-enhanced magnetic resonance imagingen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1053-8119&volume=54&spage=389&epage=395&date=2011&atitle=In+vivo+retinotopic+mapping+of+superior+colliculus+using+manganese-enhanced+magnetic+resonance+imagingen_US
dc.identifier.emailZhou, IY: izhou@hku.hken_HK
dc.identifier.emailSo, KF: hrmaskf@hku.hken_HK
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_HK
dc.identifier.authorityZhou, IY=rp01739en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neuroimage.2010.07.015en_HK
dc.identifier.pmid20633657en_HK
dc.identifier.scopuseid_2-s2.0-77957939969en_HK
dc.identifier.hkuros184649en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77957939969&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume54en_HK
dc.identifier.issue1en_HK
dc.identifier.spage389en_HK
dc.identifier.epage395en_HK
dc.identifier.isiWOS:000283825000041-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, KC=34968940300en_HK
dc.identifier.scopusauthoridLi, J=37031540600en_HK
dc.identifier.scopusauthoridKau, P=15136310300en_HK
dc.identifier.scopusauthoridZhou, IY=35424838500en_HK
dc.identifier.scopusauthoridCheung, MM=24333907800en_HK
dc.identifier.scopusauthoridLau, C=36655866600en_HK
dc.identifier.scopusauthoridYang, J=10041733800en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK

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