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Article: Adrenomedullin increases ciliary beat frequency and decreases muscular contraction in the rat oviduct

TitleAdrenomedullin increases ciliary beat frequency and decreases muscular contraction in the rat oviduct
Authors
KeywordsAdrenomedullin - genetics - metabolism - pharmacology - physiology
Cilia - drug effects - metabolism - physiology
Fallopian Tubes - cytology - drug effects - metabolism - physiology
Movement - drug effects
Muscle Contraction - drug effects
Issue Date2011
PublisherBioScientifica Ltd. The Journal's web site is located at http://www.reproduction-online.org
Citation
Reproduction, 2011, v. 141 n. 3, p. 367-372 How to Cite?
AbstractOur laboratory previously showed that oviduct produced the greatest amount of adrenomedullin (ADM) in the rat female reproductive tract. The aim of this study is to investigate the changes in ADM levels resulting from the contact between the sperm and the oviduct and the possible roles of ADM in ciliary beating and oviductal contractility. Oviducts from Sprague-Dawley rats removed at pre- and post-ovulatory stages were cut open longitudinally and treated with ADM and/or receptor blockers before ciliary beat frequency (CBF) was measured. The effects of sperm on ADM production and CBF in the oviduct were also determined. The contraction of the oviduct after treatment with ADM and receptor antagonists was measured using the organ-bath technique. The results showed that ADM increased the CBF in rat oviduct and this stimulating effect was blocked by the calcitonin-gene-related peptide (CGRP) receptor antagonist, hCGRP 8-37. CBF was lower in post-ovulatory than pre-ovulatory oviducts. The presence of sperm in the oviduct increased both the ADM level and CBF. ADM treatment was shown to inhibit the contractility of the oviduct by lowering the basal tone and decreasing the contraction amplitude. The ADM receptor antagonist, hADM 22-52, was effective in counteracting the relaxation effect of ADM in the oviduct. All in all, these results indicate that ADM may play a crucial role in transporting the gametes/embryos by regulating ciliary beating and muscular contraction. © 2011 Society for Reproduction and Fertility.
Persistent Identifierhttp://hdl.handle.net/10722/142311
ISSN
2015 Impact Factor: 3.184
2015 SCImago Journal Rankings: 1.472
ISI Accession Number ID
Funding AgencyGrant Number
Committee of Research and Conference Grant (CRCG), University of Hong Kong
Funding Information:

This work was supported by a grant from the Committee of Research and Conference Grant (CRCG), the University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorLiao, SBen_HK
dc.contributor.authorHo, JCen_HK
dc.contributor.authorTang, Fen_HK
dc.contributor.authorO, WSen_HK
dc.date.accessioned2011-10-28T02:42:40Z-
dc.date.available2011-10-28T02:42:40Z-
dc.date.issued2011en_HK
dc.identifier.citationReproduction, 2011, v. 141 n. 3, p. 367-372en_HK
dc.identifier.issn1470-1626en_HK
dc.identifier.urihttp://hdl.handle.net/10722/142311-
dc.description.abstractOur laboratory previously showed that oviduct produced the greatest amount of adrenomedullin (ADM) in the rat female reproductive tract. The aim of this study is to investigate the changes in ADM levels resulting from the contact between the sperm and the oviduct and the possible roles of ADM in ciliary beating and oviductal contractility. Oviducts from Sprague-Dawley rats removed at pre- and post-ovulatory stages were cut open longitudinally and treated with ADM and/or receptor blockers before ciliary beat frequency (CBF) was measured. The effects of sperm on ADM production and CBF in the oviduct were also determined. The contraction of the oviduct after treatment with ADM and receptor antagonists was measured using the organ-bath technique. The results showed that ADM increased the CBF in rat oviduct and this stimulating effect was blocked by the calcitonin-gene-related peptide (CGRP) receptor antagonist, hCGRP 8-37. CBF was lower in post-ovulatory than pre-ovulatory oviducts. The presence of sperm in the oviduct increased both the ADM level and CBF. ADM treatment was shown to inhibit the contractility of the oviduct by lowering the basal tone and decreasing the contraction amplitude. The ADM receptor antagonist, hADM 22-52, was effective in counteracting the relaxation effect of ADM in the oviduct. All in all, these results indicate that ADM may play a crucial role in transporting the gametes/embryos by regulating ciliary beating and muscular contraction. © 2011 Society for Reproduction and Fertility.en_HK
dc.languageengen_US
dc.publisherBioScientifica Ltd. The Journal's web site is located at http://www.reproduction-online.orgen_HK
dc.relation.ispartofReproductionen_HK
dc.subjectAdrenomedullin - genetics - metabolism - pharmacology - physiology-
dc.subjectCilia - drug effects - metabolism - physiology-
dc.subjectFallopian Tubes - cytology - drug effects - metabolism - physiology-
dc.subjectMovement - drug effects-
dc.subjectMuscle Contraction - drug effects-
dc.titleAdrenomedullin increases ciliary beat frequency and decreases muscular contraction in the rat oviducten_HK
dc.typeArticleen_HK
dc.identifier.emailTang, F: ftang@hkucc.hku.hken_HK
dc.identifier.emailO, WS: owaisum@hkucc.hku.hken_HK
dc.identifier.authorityTang, F=rp00327en_HK
dc.identifier.authorityO, WS=rp00315en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1530/REP-10-0230en_HK
dc.identifier.pmid21173072-
dc.identifier.scopuseid_2-s2.0-79952146206en_HK
dc.identifier.hkuros184622en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952146206&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume141en_HK
dc.identifier.issue3en_HK
dc.identifier.spage367en_HK
dc.identifier.epage372en_HK
dc.identifier.eissn1741-7899-
dc.identifier.isiWOS:000287572200008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLiao, SB=36170881600en_HK
dc.identifier.scopusauthoridHo, JC=7402650173en_HK
dc.identifier.scopusauthoridTang, F=7201979770en_HK
dc.identifier.scopusauthoridO, WS=6701729369en_HK

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