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Article: Novel endothelial biomarkers: Implications for periodontal disease and CVD

TitleNovel endothelial biomarkers: Implications for periodontal disease and CVD
Authors
Keywordsendothelial cells
inflammation
periodontal disease
progenitor cells
Issue Date2011
PublisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925
Citation
Journal Of Dental Research, 2011, v. 90 n. 9, p. 1062-1069 How to Cite?
AbstractEndothelial cells are actively involved in various aspects of vascular biology and different stages of atherosclerosis. Endothelial function is increasingly used as an important outcome measure in cardiovascular research. Endothelial progenitor cells (EPCs) are closely linked to endothelial function, and their biomarkers have received much attention. EPCs may not only serve as a pool of progenitor cells and possess the capacity to repair the damaged vasculature, but also act as potent effectors in systemic inflammation, suggesting that EPCs may play a critical role in maintaining endothelial function and the progression of cardiovascular disease (CVD). Emerging evidence shows an association of periodontal infections (gingivitis and periodontitis) with endothelial dysfunction, while the relevant mechanisms remain unknown. Our recent finding of the association of periodontitis with EPCs warrants their utilization as additional biomarkers in future studies on periodontal medicine. This review starts with a brief account on the current understanding of the nature of periodontal infections and their link with systemic inflammation and endothelial dysfunction. The paper also provides an update on endothelial biology and function as well as the novel biomarkers of EPCs and concludes with clinical studies on periodontal diseases and CVD. © 2011 International & American Associations for Dental Research.
Persistent Identifierhttp://hdl.handle.net/10722/142288
ISSN
2015 Impact Factor: 4.602
2015 SCImago Journal Rankings: 1.714
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU766909M
University of Hong KongCRCG 200507176137
200607176038
200907176052
Funding Information:

This work has been supported by the Hong Kong Research Grants Council (HKU766909M) and The University of Hong Kong (CRCG 200507176137, 200607176038, and 200907176052). The authors declare that they have no conflicts of interest.

References

 

DC FieldValueLanguage
dc.contributor.authorLi, Xen_HK
dc.contributor.authorTse, HFen_HK
dc.contributor.authorJin, LJen_HK
dc.date.accessioned2011-10-28T02:42:07Z-
dc.date.available2011-10-28T02:42:07Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Dental Research, 2011, v. 90 n. 9, p. 1062-1069en_HK
dc.identifier.issn0022-0345en_HK
dc.identifier.urihttp://hdl.handle.net/10722/142288-
dc.description.abstractEndothelial cells are actively involved in various aspects of vascular biology and different stages of atherosclerosis. Endothelial function is increasingly used as an important outcome measure in cardiovascular research. Endothelial progenitor cells (EPCs) are closely linked to endothelial function, and their biomarkers have received much attention. EPCs may not only serve as a pool of progenitor cells and possess the capacity to repair the damaged vasculature, but also act as potent effectors in systemic inflammation, suggesting that EPCs may play a critical role in maintaining endothelial function and the progression of cardiovascular disease (CVD). Emerging evidence shows an association of periodontal infections (gingivitis and periodontitis) with endothelial dysfunction, while the relevant mechanisms remain unknown. Our recent finding of the association of periodontitis with EPCs warrants their utilization as additional biomarkers in future studies on periodontal medicine. This review starts with a brief account on the current understanding of the nature of periodontal infections and their link with systemic inflammation and endothelial dysfunction. The paper also provides an update on endothelial biology and function as well as the novel biomarkers of EPCs and concludes with clinical studies on periodontal diseases and CVD. © 2011 International & American Associations for Dental Research.en_HK
dc.languageengen_US
dc.publisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925en_HK
dc.relation.ispartofJournal of Dental Researchen_HK
dc.rightsJournal of Dental Research. Copyright © Sage Publications, Inc..-
dc.subjectendothelial cellsen_HK
dc.subjectinflammationen_HK
dc.subjectperiodontal diseaseen_HK
dc.subjectprogenitor cellsen_HK
dc.subject.meshBiological Markers - metabolism-
dc.subject.meshCardiovascular Diseases - etiology-
dc.subject.meshEndothelial Cells - metabolism-
dc.subject.meshEndothelium, Vascular - cytology - metabolism-
dc.subject.meshPeriodontitis - complications-
dc.titleNovel endothelial biomarkers: Implications for periodontal disease and CVDen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-0345&volume=90&issue=9&spage=1062&epage=1069&date=2011&atitle=Novel+endothelial+biomarkers:+implications+for+periodontal+disease+and+CVD-
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.emailJin, LJ:ljjin@hkucc.hku.hken_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.identifier.authorityJin, LJ=rp00028en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1177/0022034510397194en_HK
dc.identifier.pmid21321068-
dc.identifier.scopuseid_2-s2.0-80051722654en_HK
dc.identifier.hkuros197071en_US
dc.identifier.hkuros196305en_US
dc.identifier.hkuros187973en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80051722654&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume90en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1062en_HK
dc.identifier.epage1069en_HK
dc.identifier.eissn1544-0591-
dc.identifier.isiWOS:000293882400004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLi, X=53881418700en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.scopusauthoridJin, LJ=7403328850en_HK

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