Article: Effect of psoralen on bone formation
| Title | Effect of psoralen on bone formation | ||||
|---|---|---|---|---|---|
| Authors | Wong, RWK1 Rabie, ABM1 | ||||
| Keywords | bone graft collagen psoralen | ||||
| Issue Date | 2011 | ||||
| Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthres | ||||
| Citation | Journal Of Orthopaedic Research, 2011, v. 29 n. 2, p. 158-164 [How to Cite?] DOI: http://dx.doi.org/10.1002/jor.21124 | ||||
| Abstract | To compare the amount of new bone and bone cells produced by psoralen in collagen matrix to that produced by collagen matrix in vivo. Eighteen bone defects, 5 mm by 10 were created in the parietal bone of nine New Zealand White rabbits. Six defects were grafted with psoralen mixed with collagen matrix. Six defects were grafted with collagen matrix alone (negative control-collagen) and six were left empty (negative controla-empty). Animals were killed on day 14 and the defects were dissected and prepared for histological assessment. Quantitative analysis of new bone formation and bone cells were made on 100 sections (50 sections for each group) using image analysis. A total of 454% more new bone was present in defects grafted with psoralen in collagen matrix than those grafted with collagen matrix. No bone was formed in the negative control-empty group. The amount of bone forming osteoblasts was also significantly greater in the psoralen group than the negative control-collagen group. Psoralen in collagen matrix has the effect of increasing new bone formation locally in vivo. Psoralen in collagen matrix can be developed as a bone graft material. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. | ||||
| ISSN | 0736-0266 2011 Impact Factor: 2.811 2011 SCImago Journal Rankings: 0.210 | ||||
| DOI | http://dx.doi.org/10.1002/jor.21124 | ||||
| ISI Accession Number ID | WOS:000286285900003
Funding Information: This study was funded by University Research Grant (10208640/36170/08000/310/01), the University of Hong Kong. Editorial assistance performed by Dr. Trevor Lane. | ||||
| References | References in Scopus |
| dc.contributor.author | Wong, RWK | ||||
|---|---|---|---|---|---|
| dc.contributor.author | Rabie, ABM | ||||
| dc.date.accessioned | 2011-10-28T02:41:59Z | ||||
| dc.date.available | 2011-10-28T02:41:59Z | ||||
| dc.date.issued | 2011 | ||||
| dc.description.abstract | To compare the amount of new bone and bone cells produced by psoralen in collagen matrix to that produced by collagen matrix in vivo. Eighteen bone defects, 5 mm by 10 were created in the parietal bone of nine New Zealand White rabbits. Six defects were grafted with psoralen mixed with collagen matrix. Six defects were grafted with collagen matrix alone (negative control-collagen) and six were left empty (negative controla-empty). Animals were killed on day 14 and the defects were dissected and prepared for histological assessment. Quantitative analysis of new bone formation and bone cells were made on 100 sections (50 sections for each group) using image analysis. A total of 454% more new bone was present in defects grafted with psoralen in collagen matrix than those grafted with collagen matrix. No bone was formed in the negative control-empty group. The amount of bone forming osteoblasts was also significantly greater in the psoralen group than the negative control-collagen group. Psoralen in collagen matrix has the effect of increasing new bone formation locally in vivo. Psoralen in collagen matrix can be developed as a bone graft material. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. | ||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||
| dc.identifier.citation | Journal Of Orthopaedic Research, 2011, v. 29 n. 2, p. 158-164 [How to Cite?] DOI: http://dx.doi.org/10.1002/jor.21124 | ||||
| dc.identifier.doi | http://dx.doi.org/10.1002/jor.21124 | ||||
| dc.identifier.epage | 164 | ||||
| dc.identifier.hkuros | 184368 | ||||
| dc.identifier.isi | WOS:000286285900003
Funding Information: This study was funded by University Research Grant (10208640/36170/08000/310/01), the University of Hong Kong. Editorial assistance performed by Dr. Trevor Lane. | ||||
| dc.identifier.issn | 0736-0266 2011 Impact Factor: 2.811 2011 SCImago Journal Rankings: 0.210 | ||||
| dc.identifier.issue | 2 | ||||
| dc.identifier.pmid | 20196083 | ||||
| dc.identifier.scopus | eid_2-s2.0-78650964953 | ||||
| dc.identifier.spage | 158 | ||||
| dc.identifier.uri | http://hdl.handle.net/10722/142273 | ||||
| dc.identifier.volume | 29 | ||||
| dc.language | eng | ||||
| dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthres | ||||
| dc.publisher.place | United States | ||||
| dc.relation.ispartof | Journal of Orthopaedic Research | ||||
| dc.relation.references | References in Scopus | ||||
| dc.rights | Journal of Orthopaedic Research. Copyright © John Wiley & Sons, Inc. | ||||
| dc.subject.mesh | Bone Regeneration - drug effects | ||||
| dc.subject.mesh | Cross-Linking Reagents - pharmacology | ||||
| dc.subject.mesh | Ficusin - pharmacology | ||||
| dc.subject.mesh | Osteogenesis - drug effects | ||||
| dc.subject.mesh | Collagen | ||||
| dc.subject | bone graft | ||||
| dc.subject | collagen | ||||
| dc.subject | psoralen | ||||
| dc.title | Effect of psoralen on bone formation | ||||
| dc.type | Article |
Author Affiliations
- Prince Philip Dental Hospital