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Article: Effect of psoralen on bone formation
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TitleEffect of psoralen on bone formation
 
AuthorsWong, RWK1
Rabie, ABM1
 
Keywordsbone graft
collagen
psoralen
 
Issue Date2011
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthres
 
CitationJournal Of Orthopaedic Research, 2011, v. 29 n. 2, p. 158-164 [How to Cite?]
DOI: http://dx.doi.org/10.1002/jor.21124
 
AbstractTo compare the amount of new bone and bone cells produced by psoralen in collagen matrix to that produced by collagen matrix in vivo. Eighteen bone defects, 5 mm by 10 were created in the parietal bone of nine New Zealand White rabbits. Six defects were grafted with psoralen mixed with collagen matrix. Six defects were grafted with collagen matrix alone (negative control-collagen) and six were left empty (negative controla-empty). Animals were killed on day 14 and the defects were dissected and prepared for histological assessment. Quantitative analysis of new bone formation and bone cells were made on 100 sections (50 sections for each group) using image analysis. A total of 454% more new bone was present in defects grafted with psoralen in collagen matrix than those grafted with collagen matrix. No bone was formed in the negative control-empty group. The amount of bone forming osteoblasts was also significantly greater in the psoralen group than the negative control-collagen group. Psoralen in collagen matrix has the effect of increasing new bone formation locally in vivo. Psoralen in collagen matrix can be developed as a bone graft material. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
 
ISSN0736-0266
2013 Impact Factor: 2.972
2013 SCImago Journal Rankings: 1.505
 
DOIhttp://dx.doi.org/10.1002/jor.21124
 
ISI Accession Number IDWOS:000286285900003
Funding AgencyGrant Number
University of Hong Kong10208640/36170/08000/310/01
Funding Information:

This study was funded by University Research Grant (10208640/36170/08000/310/01), the University of Hong Kong. Editorial assistance performed by Dr. Trevor Lane.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorWong, RWK
 
dc.contributor.authorRabie, ABM
 
dc.date.accessioned2011-10-28T02:41:59Z
 
dc.date.available2011-10-28T02:41:59Z
 
dc.date.issued2011
 
dc.description.abstractTo compare the amount of new bone and bone cells produced by psoralen in collagen matrix to that produced by collagen matrix in vivo. Eighteen bone defects, 5 mm by 10 were created in the parietal bone of nine New Zealand White rabbits. Six defects were grafted with psoralen mixed with collagen matrix. Six defects were grafted with collagen matrix alone (negative control-collagen) and six were left empty (negative controla-empty). Animals were killed on day 14 and the defects were dissected and prepared for histological assessment. Quantitative analysis of new bone formation and bone cells were made on 100 sections (50 sections for each group) using image analysis. A total of 454% more new bone was present in defects grafted with psoralen in collagen matrix than those grafted with collagen matrix. No bone was formed in the negative control-empty group. The amount of bone forming osteoblasts was also significantly greater in the psoralen group than the negative control-collagen group. Psoralen in collagen matrix has the effect of increasing new bone formation locally in vivo. Psoralen in collagen matrix can be developed as a bone graft material. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Orthopaedic Research, 2011, v. 29 n. 2, p. 158-164 [How to Cite?]
DOI: http://dx.doi.org/10.1002/jor.21124
 
dc.identifier.doihttp://dx.doi.org/10.1002/jor.21124
 
dc.identifier.epage164
 
dc.identifier.hkuros184368
 
dc.identifier.isiWOS:000286285900003
Funding AgencyGrant Number
University of Hong Kong10208640/36170/08000/310/01
Funding Information:

This study was funded by University Research Grant (10208640/36170/08000/310/01), the University of Hong Kong. Editorial assistance performed by Dr. Trevor Lane.

 
dc.identifier.issn0736-0266
2013 Impact Factor: 2.972
2013 SCImago Journal Rankings: 1.505
 
dc.identifier.issue2
 
dc.identifier.pmid20196083
 
dc.identifier.scopuseid_2-s2.0-78650964953
 
dc.identifier.spage158
 
dc.identifier.urihttp://hdl.handle.net/10722/142273
 
dc.identifier.volume29
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthres
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Orthopaedic Research
 
dc.relation.referencesReferences in Scopus
 
dc.rightsJournal of Orthopaedic Research. Copyright © John Wiley & Sons, Inc.
 
dc.subject.meshBone Regeneration - drug effects
 
dc.subject.meshCross-Linking Reagents - pharmacology
 
dc.subject.meshFicusin - pharmacology
 
dc.subject.meshOsteogenesis - drug effects
 
dc.subject.meshCollagen
 
dc.subjectbone graft
 
dc.subjectcollagen
 
dc.subjectpsoralen
 
dc.titleEffect of psoralen on bone formation
 
dc.typeArticle
 
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Author Affiliations
  1. Prince Philip Dental Hospital