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Article: Effect of psoralen on bone formation

TitleEffect of psoralen on bone formation
Authors
Keywordsbone graft
collagen
psoralen
Issue Date2011
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthres
Citation
Journal Of Orthopaedic Research, 2011, v. 29 n. 2, p. 158-164 How to Cite?
AbstractTo compare the amount of new bone and bone cells produced by psoralen in collagen matrix to that produced by collagen matrix in vivo. Eighteen bone defects, 5 mm by 10 were created in the parietal bone of nine New Zealand White rabbits. Six defects were grafted with psoralen mixed with collagen matrix. Six defects were grafted with collagen matrix alone (negative control-collagen) and six were left empty (negative controla-empty). Animals were killed on day 14 and the defects were dissected and prepared for histological assessment. Quantitative analysis of new bone formation and bone cells were made on 100 sections (50 sections for each group) using image analysis. A total of 454% more new bone was present in defects grafted with psoralen in collagen matrix than those grafted with collagen matrix. No bone was formed in the negative control-empty group. The amount of bone forming osteoblasts was also significantly greater in the psoralen group than the negative control-collagen group. Psoralen in collagen matrix has the effect of increasing new bone formation locally in vivo. Psoralen in collagen matrix can be developed as a bone graft material. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/142273
ISSN
2014 Impact Factor: 2.986
2013 SCImago Journal Rankings: 1.505
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong10208640/36170/08000/310/01
Funding Information:

This study was funded by University Research Grant (10208640/36170/08000/310/01), the University of Hong Kong. Editorial assistance performed by Dr. Trevor Lane.

References

 

DC FieldValueLanguage
dc.contributor.authorWong, RWKen_HK
dc.contributor.authorRabie, ABMen_HK
dc.date.accessioned2011-10-28T02:41:59Z-
dc.date.available2011-10-28T02:41:59Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Orthopaedic Research, 2011, v. 29 n. 2, p. 158-164en_HK
dc.identifier.issn0736-0266en_HK
dc.identifier.urihttp://hdl.handle.net/10722/142273-
dc.description.abstractTo compare the amount of new bone and bone cells produced by psoralen in collagen matrix to that produced by collagen matrix in vivo. Eighteen bone defects, 5 mm by 10 were created in the parietal bone of nine New Zealand White rabbits. Six defects were grafted with psoralen mixed with collagen matrix. Six defects were grafted with collagen matrix alone (negative control-collagen) and six were left empty (negative controla-empty). Animals were killed on day 14 and the defects were dissected and prepared for histological assessment. Quantitative analysis of new bone formation and bone cells were made on 100 sections (50 sections for each group) using image analysis. A total of 454% more new bone was present in defects grafted with psoralen in collagen matrix than those grafted with collagen matrix. No bone was formed in the negative control-empty group. The amount of bone forming osteoblasts was also significantly greater in the psoralen group than the negative control-collagen group. Psoralen in collagen matrix has the effect of increasing new bone formation locally in vivo. Psoralen in collagen matrix can be developed as a bone graft material. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthresen_HK
dc.relation.ispartofJournal of Orthopaedic Researchen_HK
dc.rightsJournal of Orthopaedic Research. Copyright © John Wiley & Sons, Inc.-
dc.subjectbone graften_HK
dc.subjectcollagenen_HK
dc.subjectpsoralenen_HK
dc.subject.meshBone Regeneration - drug effects-
dc.subject.meshCross-Linking Reagents - pharmacology-
dc.subject.meshFicusin - pharmacology-
dc.subject.meshOsteogenesis - drug effects-
dc.subject.meshCollagen-
dc.titleEffect of psoralen on bone formationen_HK
dc.typeArticleen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jor.21124en_HK
dc.identifier.pmid20196083en_HK
dc.identifier.scopuseid_2-s2.0-78650964953en_HK
dc.identifier.hkuros184368en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78650964953&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue2en_HK
dc.identifier.spage158en_HK
dc.identifier.epage164en_HK
dc.identifier.isiWOS:000286285900003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, RWK=36642905800en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK

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