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Article: Effect of periodontal treatment on circulating CD34 + cells and peripheral vascular endothelial function: A randomized controlled trial

TitleEffect of periodontal treatment on circulating CD34 + cells and peripheral vascular endothelial function: A randomized controlled trial
Authors
Keywordsatherosclerosis
clinical trial
endothelial function
inflammation
periodontal disease
progenitor cells
Issue Date2011
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPE
Citation
Journal Of Clinical Periodontology, 2011, v. 38 n. 2, p. 148-156 How to Cite?
AbstractAim: Periodontal disease is associated with endothelial dysfunction and increased circulating progenitor cell (CPC) count. This study sought to investigate the effect of periodontal treatment on CPC count and vascular endothelial function. Materials and Methods: A single-blind, randomized controlled trial was conducted in 50 otherwise healthy subjects with moderate-to-severe chronic periodontitis. They were randomly assigned into Treatment group (n=25), in whom periodontal treatment was conducted immediately, and Control group (n=25), in whom periodontal treatment was postponed until the completion of this 3-month study. CPCs and peripheral endothelial function were evaluated at baseline and 3-month follow-up using flow cytometry and peripheral arterial tonometry, respectively. Results: Based on the intention-to-treat analysis, periodontal treatment exhibited neutral effects on endothelial function [treatment effect: 0.03, 95% confidence interval (CI): -0.29 to 0.35, p=0.85]. However, circulating CD34 + cells count significantly decreased in the Treatment group compared with the controls (treatment effect: -29.85 cells/μl, 95% CI: -52.62 to -7.08, p=0.011). The reduction of circulating CD34 + count was positively correlated with the decrease in sites% with bleeding on probing or periodontal pockets 4 mm. Conclusions: This study suggests that treatment of periodontitis has neutral effects on peripheral endothelial function but significantly decreases circulating CD34 + cell count. © 2010 John Wiley & Sons A/S.
Persistent Identifierhttp://hdl.handle.net/10722/142262
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU 7518/05M
HKU766909M
University of Hong Kong200507176137
2006 07176038
200707176095
200907176 052
Sun Chieh Yeh Heart Foundation
Funding Information:

This study was supported by the Hong Kong Research Grants Council (HKU 7518/05M and HKU766909M), The University of Hong Kong (CRCG Funds 200507176137, 2006 07176038, 200707176095 and 200907176 052) and the Sun Chieh Yeh Heart Foundation. This clinical trial was registered at http://www.hkclinicaltrials.com, No. HKCT R-458.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorLi, Xen_HK
dc.contributor.authorTse, HFen_HK
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorLi, LSWen_HK
dc.contributor.authorJin, Len_HK
dc.date.accessioned2011-10-28T02:41:54Z-
dc.date.available2011-10-28T02:41:54Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Clinical Periodontology, 2011, v. 38 n. 2, p. 148-156en_HK
dc.identifier.issn0303-6979en_HK
dc.identifier.urihttp://hdl.handle.net/10722/142262-
dc.description.abstractAim: Periodontal disease is associated with endothelial dysfunction and increased circulating progenitor cell (CPC) count. This study sought to investigate the effect of periodontal treatment on CPC count and vascular endothelial function. Materials and Methods: A single-blind, randomized controlled trial was conducted in 50 otherwise healthy subjects with moderate-to-severe chronic periodontitis. They were randomly assigned into Treatment group (n=25), in whom periodontal treatment was conducted immediately, and Control group (n=25), in whom periodontal treatment was postponed until the completion of this 3-month study. CPCs and peripheral endothelial function were evaluated at baseline and 3-month follow-up using flow cytometry and peripheral arterial tonometry, respectively. Results: Based on the intention-to-treat analysis, periodontal treatment exhibited neutral effects on endothelial function [treatment effect: 0.03, 95% confidence interval (CI): -0.29 to 0.35, p=0.85]. However, circulating CD34 + cells count significantly decreased in the Treatment group compared with the controls (treatment effect: -29.85 cells/μl, 95% CI: -52.62 to -7.08, p=0.011). The reduction of circulating CD34 + count was positively correlated with the decrease in sites% with bleeding on probing or periodontal pockets 4 mm. Conclusions: This study suggests that treatment of periodontitis has neutral effects on peripheral endothelial function but significantly decreases circulating CD34 + cell count. © 2010 John Wiley & Sons A/S.en_HK
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPEen_HK
dc.relation.ispartofJournal of Clinical Periodontologyen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectatherosclerosisen_HK
dc.subjectclinical trialen_HK
dc.subjectendothelial functionen_HK
dc.subjectinflammationen_HK
dc.subjectperiodontal diseaseen_HK
dc.subjectprogenitor cellsen_HK
dc.subject.meshAntigens, CD34 - blood-
dc.subject.meshBlood Cells - cytology - metabolism-
dc.subject.meshChronic Periodontitis - blood - therapy-
dc.subject.meshEndothelial Cells - cytology - metabolism-
dc.subject.meshStem Cells - cytology - metabolism-
dc.titleEffect of periodontal treatment on circulating CD34 + cells and peripheral vascular endothelial function: A randomized controlled trialen_HK
dc.typeArticleen_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.emailYiu, KH:khkyiu@hku.hken_HK
dc.identifier.emailJin, L:ljjin@hkucc.hku.hken_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.identifier.authorityYiu, KH=rp01490en_HK
dc.identifier.authorityJin, L=rp00028en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-051X.2010.01651.xen_HK
dc.identifier.pmid21133981-
dc.identifier.scopuseid_2-s2.0-78651309026en_HK
dc.identifier.hkuros184111en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78651309026&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume38en_HK
dc.identifier.issue2en_HK
dc.identifier.spage148en_HK
dc.identifier.epage156en_HK
dc.identifier.eissn1600-051X-
dc.identifier.isiWOS:000286000500007-
dc.publisher.placeDenmarken_HK
dc.relation.projectNovel molecular mechanisms of innate host defense - implications in periodontal health and disease-
dc.identifier.scopusauthoridLi, X=36012471800en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.scopusauthoridYiu, KH=35172267800en_HK
dc.identifier.scopusauthoridLi, LSW=35337345300en_HK
dc.identifier.scopusauthoridJin, L=7403328850en_HK

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