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Article: Combined photodynamic and low-level laser therapies as an adjunct to nonsurgical treatment of chronic periodontitis

TitleCombined photodynamic and low-level laser therapies as an adjunct to nonsurgical treatment of chronic periodontitis
Authors
KeywordsDiode laser
Gingival crevicular fluid
Interleukin-1β
Periodontal disease
Periodontal therapy
Photodynamic therapy
Issue Date2011
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1
Citation
Journal Of Periodontal Research, 2011, v. 46 n. 1, p. 89-96 How to Cite?
AbstractLui J, Corbet EF, Jin L. Combined photodynamic and low-level laser therapies as an adjunct to nonsurgical treatment of chronic periodontitis. J Periodont Res 2011; 46: 89-96. © 2010 John Wiley & Sons A/S Background and Objective: In recent years, there has been a growing interest in the use of dental lasers for treatment of periodontal diseases. The purpose of this short-term clinical trial was to evaluate the effects of a combination of photodynamic therapy with low-level laser therapy as an adjunct to nonsurgical treatment of chronic periodontitis.Material and Methods: Twenty-four nonsmoking adults with untreated chronic periodontitis were randomly assigned in a split-mouth design to receive scaling and root debridement with or without one course of adjunctive photodynamic therapy and low-level laser therapy within 5 d. Plaque, bleeding on probing, probing depth and gingival recession were recorded at baseline, 1 and 3 mo after the treatment. Gingival crevicular fluid was collected for assay of interleukin-1β levels at baseline, 1 wk and 1 mo.Results: The test teeth achieved greater reductions in the percentage of sites with bleeding on probing and in mean probing depth at 1 mo compared with the control teeth (p < 0.05). A significant decrease in gingival crevicular fluid volume was observed in both groups at 1 wk (p < 0.001), with a further decrease at 1 mo in the test sites (p < 0.05). The test sites showed a greater reduction of interleukin-1β levels in gingival crevicular fluid at 1 wk than the control sites (p < 0.05). No significant differences in periodontal parameters were found between the test and control teeth at 3 mo.Conclusions: The present study suggests that a combined course of photodynamic therapy with low-level laser therapy could be a beneficial adjunct to nonsurgical treatment of chronic periodontitis on a short-term basis. Further studies are required to assess the long-term effectiveness of the combination of photodynamic therapy with low-level laser therapy as an adjunct in nonsurgical treatment of periodontitis. © 2010 John Wiley & Sons A/S.
Persistent Identifierhttp://hdl.handle.net/10722/142261
ISSN
2015 Impact Factor: 2.474
2015 SCImago Journal Rankings: 0.932
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong200807176048
Research Grants Council of Hong KongHKU 766909M
Funding Information:

The authors are grateful to Dr Qian Lu and Mr Wei Luo for their help in gingival crevicular fluid analysis. We also thank Dr William Chen for his help with the study. We acknowledge Keenworld Technology Limited, Hong Kong for providing the diode laser and photosensitizer. This study was supported by The University of Hong Kong (CRCG Fund 200807176048) and in part by the General Research Fund from the Research Grants Council of Hong Kong (HKU 766909M).

References
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DC FieldValueLanguage
dc.contributor.authorLui, Jen_HK
dc.contributor.authorCorbet, EFen_HK
dc.contributor.authorJin, Len_HK
dc.date.accessioned2011-10-28T02:41:54Z-
dc.date.available2011-10-28T02:41:54Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Periodontal Research, 2011, v. 46 n. 1, p. 89-96en_HK
dc.identifier.issn0022-3484en_HK
dc.identifier.urihttp://hdl.handle.net/10722/142261-
dc.description.abstractLui J, Corbet EF, Jin L. Combined photodynamic and low-level laser therapies as an adjunct to nonsurgical treatment of chronic periodontitis. J Periodont Res 2011; 46: 89-96. © 2010 John Wiley & Sons A/S Background and Objective: In recent years, there has been a growing interest in the use of dental lasers for treatment of periodontal diseases. The purpose of this short-term clinical trial was to evaluate the effects of a combination of photodynamic therapy with low-level laser therapy as an adjunct to nonsurgical treatment of chronic periodontitis.Material and Methods: Twenty-four nonsmoking adults with untreated chronic periodontitis were randomly assigned in a split-mouth design to receive scaling and root debridement with or without one course of adjunctive photodynamic therapy and low-level laser therapy within 5 d. Plaque, bleeding on probing, probing depth and gingival recession were recorded at baseline, 1 and 3 mo after the treatment. Gingival crevicular fluid was collected for assay of interleukin-1β levels at baseline, 1 wk and 1 mo.Results: The test teeth achieved greater reductions in the percentage of sites with bleeding on probing and in mean probing depth at 1 mo compared with the control teeth (p < 0.05). A significant decrease in gingival crevicular fluid volume was observed in both groups at 1 wk (p < 0.001), with a further decrease at 1 mo in the test sites (p < 0.05). The test sites showed a greater reduction of interleukin-1β levels in gingival crevicular fluid at 1 wk than the control sites (p < 0.05). No significant differences in periodontal parameters were found between the test and control teeth at 3 mo.Conclusions: The present study suggests that a combined course of photodynamic therapy with low-level laser therapy could be a beneficial adjunct to nonsurgical treatment of chronic periodontitis on a short-term basis. Further studies are required to assess the long-term effectiveness of the combination of photodynamic therapy with low-level laser therapy as an adjunct in nonsurgical treatment of periodontitis. © 2010 John Wiley & Sons A/S.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1en_HK
dc.relation.ispartofJournal of Periodontal Researchen_HK
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.subjectDiode laseren_HK
dc.subjectGingival crevicular fluiden_HK
dc.subjectInterleukin-1βen_HK
dc.subjectPeriodontal diseaseen_HK
dc.subjectPeriodontal therapyen_HK
dc.subjectPhotodynamic therapyen_HK
dc.subject.meshChronic Periodontitis - drug therapy - radiotherapy-
dc.subject.meshGingival Crevicular Fluid - chemistry-
dc.subject.meshLaser Therapy, Low-Level-
dc.subject.meshPhotochemotherapy-
dc.subject.meshDental Scaling-
dc.titleCombined photodynamic and low-level laser therapies as an adjunct to nonsurgical treatment of chronic periodontitisen_HK
dc.typeArticleen_HK
dc.identifier.emailCorbet, EF:efcorbet@hku.hken_HK
dc.identifier.emailJin, L:ljjin@hkucc.hku.hken_HK
dc.identifier.authorityCorbet, EF=rp00005en_HK
dc.identifier.authorityJin, L=rp00028en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-0765.2010.01316.xen_HK
dc.identifier.pmid20860592-
dc.identifier.scopuseid_2-s2.0-78650892622en_HK
dc.identifier.hkuros184103en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78650892622&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume46en_HK
dc.identifier.issue1en_HK
dc.identifier.spage89en_HK
dc.identifier.epage96en_HK
dc.identifier.eissn1600-0765-
dc.identifier.isiWOS:000285969300011-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectModulation of innate immune responses in human gingiva by P. gingivalis lipopolysaccharide with lipid A heterogeneity: Novel molecular mechanisms and clinical implications-
dc.identifier.scopusauthoridLui, J=36816045200en_HK
dc.identifier.scopusauthoridCorbet, EF=35609873200en_HK
dc.identifier.scopusauthoridJin, L=7403328850en_HK
dc.identifier.citeulike8618691-

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