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Article: In Vitro characterization of low modulus linoleic acid coated strontium-substituted hydroxyapatite containing PMMA bone cement
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TitleIn Vitro characterization of low modulus linoleic acid coated strontium-substituted hydroxyapatite containing PMMA bone cement
 
AuthorsLam, WM1
Pan, HB1
Fong, MK1
Cheung, WS1
Wong, KL1
Li, ZY1
Luk, KDK1
Chan, WK1
Wong, CT1
Yang, C2
Lu, WW1
 
Keywordslinoleic acid
polymethylmethacrylate
strontium-substituted hydroxyapatite (Sr-HA)
vertebroplasty
 
Issue Date2011
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/
 
CitationJournal Of Biomedical Materials Research - Part B Applied Biomaterials, 2011, v. 96 B n. 1, p. 76-83 [How to Cite?]
DOI: http://dx.doi.org/10.1002/jbm.b.31741
 
AbstractPoly (methyl methacrylate) (PMMA) bone cement is widely used in vertebral body augmentation procedures such as vertebroplasty and balloon kyphoplasty. Filling high modulus PMMA increases the modulus of filled verterbra, increasing the risk of fracture in the adjacent vertebra. On the other hand, in porous PMMA bone cements, wear particle generation and deterioration of mechanical performance are the major drawbacks. This study adopts a new approach by utilizing linoleic acid coated strontium substituted hydroxyapatite nanoparticle (Sr-5 HA) and linoleic acid as plasticizer reducing bone cement's modulus with minimal impact on its strength. We determined the compressive strength (UCS) and modulus (Ec), hydrophobicity, injectability, in vitro bioactivity and biocompatibility of this bone cement at different filler and linoleic acid loading. At 20 wt % Sr5-HA incorporation, UCS and Ec were reduced from 63 ± 2 MPa, 2142 ± 129 MPa to 58 ± 2 MPa, 1785 ± 64 MPa, respectively. UCS and Ec were further reduced to 49 ± 2 MPa and 774 ± 70 MPa respectively when 15 v/v of linoleic acid was incorporated. After 7 days of incubation, pre-osteoblast cells (MC3T3-E1) attached on 20 wt % Sr5-HA and 20 wt % Sr5-HA with 15 v/v of linoleic acid group were higher (3.73 ± 0.01 × 10 4, 2.27 ± 0.02 × 10 4) than their PMMA counterpart (1.83 ± 0.04 × 10 4). Incorporation of Sr5-HA with linoleic acid in monomer phase is more effective in reducing the bone cement's stiffness than Sr5-HA alone. Combination of low stiffness and high mechanical strength gives the novel bone cement the potential for use in vertebroplasty cement applications. © 2010 Wiley Periodicals, Inc.
 
ISSN1552-4973
2012 Impact Factor: 2.308
2012 SCImago Journal Rankings: 0.755
 
DOIhttp://dx.doi.org/10.1002/jbm.b.31741
 
ISI Accession Number IDWOS:000285225500009
Funding AgencyGrant Number
RGCHKU7147/07E
Hong Kong Innovation and Technology CommissionGHP/009/06
Funding Information:

We thank the Electron Microscopy Unit, the Department of Mechanical Engineering of the University of Hong Kong for their technical support. This project is partially supported by RGC HKU7147/07E.

 
ReferencesReferences in Scopus
 
GrantsOptimization and commercialization of strontium containing bioactive bone cement for various orthopaedic applications
 
DC FieldValue
dc.contributor.authorLam, WM
 
dc.contributor.authorPan, HB
 
dc.contributor.authorFong, MK
 
dc.contributor.authorCheung, WS
 
dc.contributor.authorWong, KL
 
dc.contributor.authorLi, ZY
 
dc.contributor.authorLuk, KDK
 
dc.contributor.authorChan, WK
 
dc.contributor.authorWong, CT
 
dc.contributor.authorYang, C
 
dc.contributor.authorLu, WW
 
dc.date.accessioned2011-10-26T08:31:38Z
 
dc.date.available2011-10-26T08:31:38Z
 
dc.date.issued2011
 
dc.description.abstractPoly (methyl methacrylate) (PMMA) bone cement is widely used in vertebral body augmentation procedures such as vertebroplasty and balloon kyphoplasty. Filling high modulus PMMA increases the modulus of filled verterbra, increasing the risk of fracture in the adjacent vertebra. On the other hand, in porous PMMA bone cements, wear particle generation and deterioration of mechanical performance are the major drawbacks. This study adopts a new approach by utilizing linoleic acid coated strontium substituted hydroxyapatite nanoparticle (Sr-5 HA) and linoleic acid as plasticizer reducing bone cement's modulus with minimal impact on its strength. We determined the compressive strength (UCS) and modulus (Ec), hydrophobicity, injectability, in vitro bioactivity and biocompatibility of this bone cement at different filler and linoleic acid loading. At 20 wt % Sr5-HA incorporation, UCS and Ec were reduced from 63 ± 2 MPa, 2142 ± 129 MPa to 58 ± 2 MPa, 1785 ± 64 MPa, respectively. UCS and Ec were further reduced to 49 ± 2 MPa and 774 ± 70 MPa respectively when 15 v/v of linoleic acid was incorporated. After 7 days of incubation, pre-osteoblast cells (MC3T3-E1) attached on 20 wt % Sr5-HA and 20 wt % Sr5-HA with 15 v/v of linoleic acid group were higher (3.73 ± 0.01 × 10 4, 2.27 ± 0.02 × 10 4) than their PMMA counterpart (1.83 ± 0.04 × 10 4). Incorporation of Sr5-HA with linoleic acid in monomer phase is more effective in reducing the bone cement's stiffness than Sr5-HA alone. Combination of low stiffness and high mechanical strength gives the novel bone cement the potential for use in vertebroplasty cement applications. © 2010 Wiley Periodicals, Inc.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Biomedical Materials Research - Part B Applied Biomaterials, 2011, v. 96 B n. 1, p. 76-83 [How to Cite?]
DOI: http://dx.doi.org/10.1002/jbm.b.31741
 
dc.identifier.doihttp://dx.doi.org/10.1002/jbm.b.31741
 
dc.identifier.epage83
 
dc.identifier.hkuros197050
 
dc.identifier.isiWOS:000285225500009
Funding AgencyGrant Number
RGCHKU7147/07E
Hong Kong Innovation and Technology CommissionGHP/009/06
Funding Information:

We thank the Electron Microscopy Unit, the Department of Mechanical Engineering of the University of Hong Kong for their technical support. This project is partially supported by RGC HKU7147/07E.

 
dc.identifier.issn1552-4973
2012 Impact Factor: 2.308
2012 SCImago Journal Rankings: 0.755
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.pmid21053263
 
dc.identifier.scopuseid_2-s2.0-78650033910
 
dc.identifier.spage76
 
dc.identifier.urihttp://hdl.handle.net/10722/142249
 
dc.identifier.volume96 B
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Biomedical Materials Research - Part B Applied Biomaterials
 
dc.relation.projectOptimization and commercialization of strontium containing bioactive bone cement for various orthopaedic applications
 
dc.relation.referencesReferences in Scopus
 
dc.rightsJournal of Biomedical Materials Research Part B: Applied Biomaterials. Copyright © John Wiley & Sons, Inc.
 
dc.subject.meshBone Cements - chemistry
 
dc.subject.meshBone Substitutes - chemistry
 
dc.subject.meshCoated Materials, Biocompatible - chemistry
 
dc.subject.meshPolymethyl Methacrylate - chemistry
 
dc.subject.meshStrontium - chemistry
 
dc.subjectlinoleic acid
 
dc.subjectpolymethylmethacrylate
 
dc.subjectstrontium-substituted hydroxyapatite (Sr-HA)
 
dc.subjectvertebroplasty
 
dc.titleIn Vitro characterization of low modulus linoleic acid coated strontium-substituted hydroxyapatite containing PMMA bone cement
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Hong Kong University of Science and Technology