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Article: In Vitro characterization of low modulus linoleic acid coated strontium-substituted hydroxyapatite containing PMMA bone cement

TitleIn Vitro characterization of low modulus linoleic acid coated strontium-substituted hydroxyapatite containing PMMA bone cement
Authors
Keywordslinoleic acid
polymethylmethacrylate
strontium-substituted hydroxyapatite (Sr-HA)
vertebroplasty
Issue Date2011
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/
Citation
Journal Of Biomedical Materials Research - Part B Applied Biomaterials, 2011, v. 96 B n. 1, p. 76-83 How to Cite?
AbstractPoly (methyl methacrylate) (PMMA) bone cement is widely used in vertebral body augmentation procedures such as vertebroplasty and balloon kyphoplasty. Filling high modulus PMMA increases the modulus of filled verterbra, increasing the risk of fracture in the adjacent vertebra. On the other hand, in porous PMMA bone cements, wear particle generation and deterioration of mechanical performance are the major drawbacks. This study adopts a new approach by utilizing linoleic acid coated strontium substituted hydroxyapatite nanoparticle (Sr-5 HA) and linoleic acid as plasticizer reducing bone cement's modulus with minimal impact on its strength. We determined the compressive strength (UCS) and modulus (Ec), hydrophobicity, injectability, in vitro bioactivity and biocompatibility of this bone cement at different filler and linoleic acid loading. At 20 wt % Sr5-HA incorporation, UCS and Ec were reduced from 63 ± 2 MPa, 2142 ± 129 MPa to 58 ± 2 MPa, 1785 ± 64 MPa, respectively. UCS and Ec were further reduced to 49 ± 2 MPa and 774 ± 70 MPa respectively when 15 v/v of linoleic acid was incorporated. After 7 days of incubation, pre-osteoblast cells (MC3T3-E1) attached on 20 wt % Sr5-HA and 20 wt % Sr5-HA with 15 v/v of linoleic acid group were higher (3.73 ± 0.01 × 10 4, 2.27 ± 0.02 × 10 4) than their PMMA counterpart (1.83 ± 0.04 × 10 4). Incorporation of Sr5-HA with linoleic acid in monomer phase is more effective in reducing the bone cement's stiffness than Sr5-HA alone. Combination of low stiffness and high mechanical strength gives the novel bone cement the potential for use in vertebroplasty cement applications. © 2010 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/142249
ISSN
2014 Impact Factor: 2.759
ISI Accession Number ID
Funding AgencyGrant Number
RGCHKU7147/07E
Hong Kong Innovation and Technology CommissionGHP/009/06
Funding Information:

We thank the Electron Microscopy Unit, the Department of Mechanical Engineering of the University of Hong Kong for their technical support. This project is partially supported by RGC HKU7147/07E.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorLam, WMen_HK
dc.contributor.authorPan, HBen_HK
dc.contributor.authorFong, MKen_HK
dc.contributor.authorCheung, WSen_HK
dc.contributor.authorWong, KLen_HK
dc.contributor.authorLi, ZYen_HK
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorChan, WKen_HK
dc.contributor.authorWong, CTen_HK
dc.contributor.authorYang, Cen_HK
dc.contributor.authorLu, WWen_HK
dc.date.accessioned2011-10-26T08:31:38Z-
dc.date.available2011-10-26T08:31:38Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Biomedical Materials Research - Part B Applied Biomaterials, 2011, v. 96 B n. 1, p. 76-83en_HK
dc.identifier.issn1552-4973en_HK
dc.identifier.urihttp://hdl.handle.net/10722/142249-
dc.description.abstractPoly (methyl methacrylate) (PMMA) bone cement is widely used in vertebral body augmentation procedures such as vertebroplasty and balloon kyphoplasty. Filling high modulus PMMA increases the modulus of filled verterbra, increasing the risk of fracture in the adjacent vertebra. On the other hand, in porous PMMA bone cements, wear particle generation and deterioration of mechanical performance are the major drawbacks. This study adopts a new approach by utilizing linoleic acid coated strontium substituted hydroxyapatite nanoparticle (Sr-5 HA) and linoleic acid as plasticizer reducing bone cement's modulus with minimal impact on its strength. We determined the compressive strength (UCS) and modulus (Ec), hydrophobicity, injectability, in vitro bioactivity and biocompatibility of this bone cement at different filler and linoleic acid loading. At 20 wt % Sr5-HA incorporation, UCS and Ec were reduced from 63 ± 2 MPa, 2142 ± 129 MPa to 58 ± 2 MPa, 1785 ± 64 MPa, respectively. UCS and Ec were further reduced to 49 ± 2 MPa and 774 ± 70 MPa respectively when 15 v/v of linoleic acid was incorporated. After 7 days of incubation, pre-osteoblast cells (MC3T3-E1) attached on 20 wt % Sr5-HA and 20 wt % Sr5-HA with 15 v/v of linoleic acid group were higher (3.73 ± 0.01 × 10 4, 2.27 ± 0.02 × 10 4) than their PMMA counterpart (1.83 ± 0.04 × 10 4). Incorporation of Sr5-HA with linoleic acid in monomer phase is more effective in reducing the bone cement's stiffness than Sr5-HA alone. Combination of low stiffness and high mechanical strength gives the novel bone cement the potential for use in vertebroplasty cement applications. © 2010 Wiley Periodicals, Inc.en_HK
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/en_HK
dc.relation.ispartofJournal of Biomedical Materials Research - Part B Applied Biomaterialsen_HK
dc.rightsJournal of Biomedical Materials Research Part B: Applied Biomaterials. Copyright © John Wiley & Sons, Inc.-
dc.subjectlinoleic aciden_HK
dc.subjectpolymethylmethacrylateen_HK
dc.subjectstrontium-substituted hydroxyapatite (Sr-HA)en_HK
dc.subjectvertebroplastyen_HK
dc.subject.meshBone Cements - chemistry-
dc.subject.meshBone Substitutes - chemistry-
dc.subject.meshCoated Materials, Biocompatible - chemistry-
dc.subject.meshPolymethyl Methacrylate - chemistry-
dc.subject.meshStrontium - chemistry-
dc.titleIn Vitro characterization of low modulus linoleic acid coated strontium-substituted hydroxyapatite containing PMMA bone cementen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1552-4973&volume=96&issue=1&spage=76&epage=83&date=2011&atitle=In+Vitro+characterization+of+low+modulus+linoleic+acid+coated+strontium-substituted+hydroxyapatite+containing+PMMA+bone+cement-
dc.identifier.emailPan, HB:haobo@hku.hken_HK
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_HK
dc.identifier.emailLu, WW:wwlu@hku.hken_HK
dc.identifier.authorityPan, HB=rp01564en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jbm.b.31741en_HK
dc.identifier.pmid21053263-
dc.identifier.scopuseid_2-s2.0-78650033910en_HK
dc.identifier.hkuros197050-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78650033910&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume96 Ben_HK
dc.identifier.issue1en_HK
dc.identifier.spage76en_HK
dc.identifier.epage83en_HK
dc.identifier.isiWOS:000285225500009-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectOptimization and commercialization of strontium containing bioactive bone cement for various orthopaedic applications-
dc.identifier.scopusauthoridLam, WM=13403256300en_HK
dc.identifier.scopusauthoridPan, HB=7403295092en_HK
dc.identifier.scopusauthoridFong, MK=26538502500en_HK
dc.identifier.scopusauthoridCheung, WS=36655523900en_HK
dc.identifier.scopusauthoridWong, KL=24460004600en_HK
dc.identifier.scopusauthoridLi, ZY=35242620900en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.scopusauthoridChan, WK=7403917961en_HK
dc.identifier.scopusauthoridWong, CT=7404954512en_HK
dc.identifier.scopusauthoridYang, C=14020919000en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK

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