Article: In Vitro characterization of low modulus linoleic acid coated strontium-substituted hydroxyapatite containing PMMA bone cement
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- Publisher Website: 10.1002/jbm.b.31741
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- PMID: 21053263
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| Title | In Vitro characterization of low modulus linoleic acid coated strontium-substituted hydroxyapatite containing PMMA bone cement |
|---|---|
| Authors | Lam, WM1 Pan, HB1 Fong, MK1 Cheung, WS1 Wong, KL1 Li, ZY1 Luk, KDK1 Chan, WK1 Wong, CT1 Yang, C2 Lu, WW1 |
| Keywords | linoleic acid polymethylmethacrylate strontium-substituted hydroxyapatite (Sr-HA) vertebroplasty |
| Issue Date | 2011 |
| Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/ |
| Citation | Journal Of Biomedical Materials Research - Part B Applied Biomaterials, 2011, v. 96 B n. 1, p. 76-83 [How to Cite?] DOI: http://dx.doi.org/10.1002/jbm.b.31741 |
| Abstract | Poly (methyl methacrylate) (PMMA) bone cement is widely used in vertebral body augmentation procedures such as vertebroplasty and balloon kyphoplasty. Filling high modulus PMMA increases the modulus of filled verterbra, increasing the risk of fracture in the adjacent vertebra. On the other hand, in porous PMMA bone cements, wear particle generation and deterioration of mechanical performance are the major drawbacks. This study adopts a new approach by utilizing linoleic acid coated strontium substituted hydroxyapatite nanoparticle (Sr-5 HA) and linoleic acid as plasticizer reducing bone cement's modulus with minimal impact on its strength. We determined the compressive strength (UCS) and modulus (Ec), hydrophobicity, injectability, in vitro bioactivity and biocompatibility of this bone cement at different filler and linoleic acid loading. At 20 wt % Sr5-HA incorporation, UCS and Ec were reduced from 63 ± 2 MPa, 2142 ± 129 MPa to 58 ± 2 MPa, 1785 ± 64 MPa, respectively. UCS and Ec were further reduced to 49 ± 2 MPa and 774 ± 70 MPa respectively when 15 v/v of linoleic acid was incorporated. After 7 days of incubation, pre-osteoblast cells (MC3T3-E1) attached on 20 wt % Sr5-HA and 20 wt % Sr5-HA with 15 v/v of linoleic acid group were higher (3.73 ± 0.01 × 10 4, 2.27 ± 0.02 × 10 4) than their PMMA counterpart (1.83 ± 0.04 × 10 4). Incorporation of Sr5-HA with linoleic acid in monomer phase is more effective in reducing the bone cement's stiffness than Sr5-HA alone. Combination of low stiffness and high mechanical strength gives the novel bone cement the potential for use in vertebroplasty cement applications. © 2010 Wiley Periodicals, Inc. |
| ISSN | 1552-4973 2011 Impact Factor: 2.147 2011 SCImago Journal Rankings: 0.138 |
| DOI | http://dx.doi.org/10.1002/jbm.b.31741 |
| References | References in Scopus |
| Grants | Optimization and commercialization of strontium containing bioactive bone cement for various orthopaedic applications |
| dc.contributor.author | Lam, WM | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Pan, HB | ||||||
| dc.contributor.author | Fong, MK | ||||||
| dc.contributor.author | Cheung, WS | ||||||
| dc.contributor.author | Wong, KL | ||||||
| dc.contributor.author | Li, ZY | ||||||
| dc.contributor.author | Luk, KDK | ||||||
| dc.contributor.author | Chan, WK | ||||||
| dc.contributor.author | Wong, CT | ||||||
| dc.contributor.author | Yang, C | ||||||
| dc.contributor.author | Lu, WW | ||||||
| dc.date.accessioned | 2011-10-26T08:31:38Z | ||||||
| dc.date.available | 2011-10-26T08:31:38Z | ||||||
| dc.date.issued | 2011 | ||||||
| dc.description.abstract | Poly (methyl methacrylate) (PMMA) bone cement is widely used in vertebral body augmentation procedures such as vertebroplasty and balloon kyphoplasty. Filling high modulus PMMA increases the modulus of filled verterbra, increasing the risk of fracture in the adjacent vertebra. On the other hand, in porous PMMA bone cements, wear particle generation and deterioration of mechanical performance are the major drawbacks. This study adopts a new approach by utilizing linoleic acid coated strontium substituted hydroxyapatite nanoparticle (Sr-5 HA) and linoleic acid as plasticizer reducing bone cement's modulus with minimal impact on its strength. We determined the compressive strength (UCS) and modulus (Ec), hydrophobicity, injectability, in vitro bioactivity and biocompatibility of this bone cement at different filler and linoleic acid loading. At 20 wt % Sr5-HA incorporation, UCS and Ec were reduced from 63 ± 2 MPa, 2142 ± 129 MPa to 58 ± 2 MPa, 1785 ± 64 MPa, respectively. UCS and Ec were further reduced to 49 ± 2 MPa and 774 ± 70 MPa respectively when 15 v/v of linoleic acid was incorporated. After 7 days of incubation, pre-osteoblast cells (MC3T3-E1) attached on 20 wt % Sr5-HA and 20 wt % Sr5-HA with 15 v/v of linoleic acid group were higher (3.73 ± 0.01 × 10 4, 2.27 ± 0.02 × 10 4) than their PMMA counterpart (1.83 ± 0.04 × 10 4). Incorporation of Sr5-HA with linoleic acid in monomer phase is more effective in reducing the bone cement's stiffness than Sr5-HA alone. Combination of low stiffness and high mechanical strength gives the novel bone cement the potential for use in vertebroplasty cement applications. © 2010 Wiley Periodicals, Inc. | ||||||
| dc.description.grant | Optimization and commercialization of strontium containing bioactive bone cement for various orthopaedic applications | ||||||
| dc.description.grantcode | 96197 | ||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||
| dc.identifier.citation | Journal Of Biomedical Materials Research - Part B Applied Biomaterials, 2011, v. 96 B n. 1, p. 76-83 [How to Cite?] DOI: http://dx.doi.org/10.1002/jbm.b.31741 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1002/jbm.b.31741 | ||||||
| dc.identifier.epage | 83 | ||||||
| dc.identifier.hkuros | 197050 | ||||||
| dc.identifier.isi | WOS:000285225500009
Funding Information: We thank the Electron Microscopy Unit, the Department of Mechanical Engineering of the University of Hong Kong for their technical support. This project is partially supported by RGC HKU7147/07E. | ||||||
| dc.identifier.issn | 1552-4973 2011 Impact Factor: 2.147 2011 SCImago Journal Rankings: 0.138 | ||||||
| dc.identifier.issue | 1 | ||||||
| dc.identifier.openurl | | ||||||
| dc.identifier.pmid | 21053263 | ||||||
| dc.identifier.scopus | eid_2-s2.0-78650033910 | ||||||
| dc.identifier.spage | 76 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/142249 | ||||||
| dc.identifier.volume | 96 B | ||||||
| dc.language | eng | ||||||
| dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/ | ||||||
| dc.publisher.place | United States | ||||||
| dc.relation.ispartof | Journal of Biomedical Materials Research - Part B Applied Biomaterials | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.rights | Journal of Biomedical Materials Research Part B: Applied Biomaterials. Copyright © John Wiley & Sons, Inc. | ||||||
| dc.subject.mesh | Bone Cements - chemistry | ||||||
| dc.subject.mesh | Bone Substitutes - chemistry | ||||||
| dc.subject.mesh | Coated Materials, Biocompatible - chemistry | ||||||
| dc.subject.mesh | Polymethyl Methacrylate - chemistry | ||||||
| dc.subject.mesh | Strontium - chemistry | ||||||
| dc.subject | linoleic acid | ||||||
| dc.subject | polymethylmethacrylate | ||||||
| dc.subject | strontium-substituted hydroxyapatite (Sr-HA) | ||||||
| dc.subject | vertebroplasty | ||||||
| dc.title | In Vitro characterization of low modulus linoleic acid coated strontium-substituted hydroxyapatite containing PMMA bone cement | ||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong
- Hong Kong University of Science and Technology