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Article: Effects of strontium in modified biomaterials
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TitleEffects of strontium in modified biomaterials
 
AuthorsZhang, W3
Shen, Y3
Pan, H2
Lin, K5
Liu, X5
Darvell, BW1
Lu, WW2
Chang, J5
Deng, L3
Wang, D4
Huang, W4
 
KeywordsBioactivity
Borosilicate
Calcium silicate
Hydroxyapatite
Strontium
 
Issue Date2011
 
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomat
 
CitationActa Biomaterialia, 2011, v. 7 n. 2, p. 800-808 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.actbio.2010.08.031
 
AbstractStrontium (Sr) plays a special role in bone remodelling, being associated with both the stimulation of bone formation and a reduction in bone resorption. Thus, the modification of biomaterials by partial or full substitution by Sr is expected to increase both bioactivity and biocompatibility. However, such effects have to be studied individually. Although no phase transition was found in Sr-substituted hydroxyapatite (Sr-HA), Sr-containing calcium silicate (Sr-CS) or Sr-containing borosilicate (Sr-BS), their biological performance was substantially affected by changes in the physico-chemical properties and Sr content of the materials. Three distinct outcomes were found for the presence of Sr: (1) increased HA solubility; (2) no significant effect on the degradation rate of CS; (3) apparent inhibition of the otherwise rapid degradation of BS. In each case the released Sr affected osteoblast proliferation and alkaline phosphatase activity, with clear evidence that an optimum Sr dose exists. Such chemical and biological variations must be disentangled for the behaviour to be properly understood and materials design to be advanced. © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
 
ISSN1742-7061
2013 Impact Factor: 5.684
2013 SCImago Journal Rankings: 2.005
 
DOIhttp://dx.doi.org/10.1016/j.actbio.2010.08.031
 
ISI Accession Number IDWOS:000286707700037
Funding AgencyGrant Number
Science and Technology Commission of Shanghai Municipality09JC1415500
084411900500
Natural Science Foundation of China30900299
51072133
Hong Kong RGCHKU7147/07E
Funding Information:

This work was funded by grants from Science and Technology Commission of Shanghai Municipality (Grants Nos. 09JC1415500 and 084411900500), Natural Science Foundation of China (Grants Nos. 30900299 and 51072133) and Hong Kong RGC HKU7147/07E.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorZhang, W
 
dc.contributor.authorShen, Y
 
dc.contributor.authorPan, H
 
dc.contributor.authorLin, K
 
dc.contributor.authorLiu, X
 
dc.contributor.authorDarvell, BW
 
dc.contributor.authorLu, WW
 
dc.contributor.authorChang, J
 
dc.contributor.authorDeng, L
 
dc.contributor.authorWang, D
 
dc.contributor.authorHuang, W
 
dc.date.accessioned2011-10-26T08:08:38Z
 
dc.date.available2011-10-26T08:08:38Z
 
dc.date.issued2011
 
dc.description.abstractStrontium (Sr) plays a special role in bone remodelling, being associated with both the stimulation of bone formation and a reduction in bone resorption. Thus, the modification of biomaterials by partial or full substitution by Sr is expected to increase both bioactivity and biocompatibility. However, such effects have to be studied individually. Although no phase transition was found in Sr-substituted hydroxyapatite (Sr-HA), Sr-containing calcium silicate (Sr-CS) or Sr-containing borosilicate (Sr-BS), their biological performance was substantially affected by changes in the physico-chemical properties and Sr content of the materials. Three distinct outcomes were found for the presence of Sr: (1) increased HA solubility; (2) no significant effect on the degradation rate of CS; (3) apparent inhibition of the otherwise rapid degradation of BS. In each case the released Sr affected osteoblast proliferation and alkaline phosphatase activity, with clear evidence that an optimum Sr dose exists. Such chemical and biological variations must be disentangled for the behaviour to be properly understood and materials design to be advanced. © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationActa Biomaterialia, 2011, v. 7 n. 2, p. 800-808 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.actbio.2010.08.031
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.actbio.2010.08.031
 
dc.identifier.eissn1878-7568
 
dc.identifier.epage808
 
dc.identifier.hkuros197046
 
dc.identifier.isiWOS:000286707700037
Funding AgencyGrant Number
Science and Technology Commission of Shanghai Municipality09JC1415500
084411900500
Natural Science Foundation of China30900299
51072133
Hong Kong RGCHKU7147/07E
Funding Information:

This work was funded by grants from Science and Technology Commission of Shanghai Municipality (Grants Nos. 09JC1415500 and 084411900500), Natural Science Foundation of China (Grants Nos. 30900299 and 51072133) and Hong Kong RGC HKU7147/07E.

 
dc.identifier.issn1742-7061
2013 Impact Factor: 5.684
2013 SCImago Journal Rankings: 2.005
 
dc.identifier.issue2
 
dc.identifier.openurl
 
dc.identifier.pmid20826233
 
dc.identifier.scopuseid_2-s2.0-78650718376
 
dc.identifier.spage800
 
dc.identifier.urihttp://hdl.handle.net/10722/142248
 
dc.identifier.volume7
 
dc.languageeng
 
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomat
 
dc.publisher.placeNetherlands
 
dc.relation.ispartofActa Biomaterialia
 
dc.relation.referencesReferences in Scopus
 
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Acta Biomaterialia. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, [VOL#7, ISSUE#2, (2011)] DOI#10.1016/j.actbio.2010.08.031
 
dc.subject.meshBiocompatible Materials - pharmacology
 
dc.subject.meshCalcium Compounds - pharmacology
 
dc.subject.meshSpectrophotometry, Atomic
 
dc.subject.meshSpectroscopy, Fourier Transform Infrared
 
dc.subject.meshStrontium - pharmacology
 
dc.subjectBioactivity
 
dc.subjectBorosilicate
 
dc.subjectCalcium silicate
 
dc.subjectHydroxyapatite
 
dc.subjectStrontium
 
dc.titleEffects of strontium in modified biomaterials
 
dc.typeArticle
 
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Author Affiliations
  1. University of Kuwait
  2. The University of Hong Kong
  3. Shanghai Jiaotong University
  4. Tongji University
  5. Shanghai Institute of Ceramics Chinese Academy of Sciences