Patent: High-throughput Diagnostic Assay For THE Human Virus Causing Severe Acute Respiratory Syndrome (sars)
| Title | High-throughput Diagnostic Assay For THE Human Virus Causing Severe Acute Respiratory Syndrome (sars) |
|---|---|
| Granted Patent | ZL200480007680.4 |
| Granted Date | 2010-06-16 |
| Inventors | Chan, Kwok Hung Guan, Yi Leung, Frederick C C Nicholls, John Malcolm Peiris, Joseph Sriyal Malik Poon, Leo Lit Man Yuen, Kwok Yung |
| Issue Date | 2011 |
| Abstract | The present invention relates to a high-throughput diagnostic assay for the virus causing Severe Acute Respiratory Syndrome (SARS) in humans ('hSARS virus'). In particular, the invention relates to a high-throughput reverse transcription-PCR diagnostic test for SARS associated coronavirus (SARS-CoV). The present assay is a rapid, reliable assay which can be used for diagnosis and monitoring the spread of SARS and is based on the nucleotide sequences of the N (nucleocapsid)-gene of the hSARS virus. The present method eliminates false negative results and provides increased sensitivity for the assay. The invention also discloses the S (spike)-gene of the hSARS virus. The invention further relates to the deduced amino acid sequences of the N-gene and S-gene products of the hSARS virus and to the use of the N-gene and S-gene products in diagnostic methods. The invention further encompasses diagnostic assays and kits comprising antibodies generated against the N-gene or S-gene product. |
| dc.contributor.inventor | Chan, Kwok Hung |
|---|---|
| dc.contributor.inventor | Guan, Yi |
| dc.contributor.inventor | Leung, Frederick C C |
| dc.contributor.inventor | Nicholls, John Malcolm |
| dc.contributor.inventor | Peiris, Joseph Sriyal Malik |
| dc.contributor.inventor | Poon, Leo Lit Man |
| dc.contributor.inventor | Yuen, Kwok Yung |
| dc.date.accessioned | 2011-10-19T06:36:03Z |
| dc.date.available | 2011-10-19T06:36:03Z |
| patents.date.granted | 2010-06-16 |
| dc.date.issued | 2011 |
| dc.description.abstract | The present invention relates to a high-throughput diagnostic assay for the virus causing Severe Acute Respiratory Syndrome (SARS) in humans ('hSARS virus'). In particular, the invention relates to a high-throughput reverse transcription-PCR diagnostic test for SARS associated coronavirus (SARS-CoV). The present assay is a rapid, reliable assay which can be used for diagnosis and monitoring the spread of SARS and is based on the nucleotide sequences of the N (nucleocapsid)-gene of the hSARS virus. The present method eliminates false negative results and provides increased sensitivity for the assay. The invention also discloses the S (spike)-gene of the hSARS virus. The invention further relates to the deduced amino acid sequences of the N-gene and S-gene products of the hSARS virus and to the use of the N-gene and S-gene products in diagnostic methods. The invention further encompasses diagnostic assays and kits comprising antibodies generated against the N-gene or S-gene product. |
| patents.description.cc | CN |
| patents.description.country | China, PRC |
| patents.identifier.granted | ZL200480007680.4 |
| patents.identifier.hkutechid | Micro-2003-00161 |
| dc.identifier.uri | http://hdl.handle.net/10722/142238 |
| dc.rights | Creative Commons: Attribution 3.0 Hong Kong License For Public Patent Documents |
| dc.title | High-throughput Diagnostic Assay For THE Human Virus Causing Severe Acute Respiratory Syndrome (sars) |
| dc.type | Patent |