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Patent: High-throughput Diagnostic Assay For THE Human Virus Causing Severe Acute Respiratory Syndrome (sars)
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TitleHigh-throughput Diagnostic Assay For THE Human Virus Causing Severe Acute Respiratory Syndrome (sars)
 
Granted PatentZL200480007680.4
 
Granted Date2010-06-16
 
InventorsChan, Kwok Hung
Guan, Yi
Leung, Frederick C C
Nicholls, John Malcolm
Peiris, Joseph Sriyal Malik
Poon, Leo Lit Man
Yuen, Kwok Yung
 
Issue Date2010
 
AbstractThe present invention relates to a high-throughput diagnostic assay for the virus causing Severe Acute Respiratory Syndrome (SARS) in humans ('hSARS virus'). In particular, the invention relates to a high-throughput reverse transcription-PCR diagnostic test for SARS associated coronavirus (SARS-CoV). The present assay is a rapid, reliable assay which can be used for diagnosis and monitoring the spread of SARS and is based on the nucleotide sequences of the N (nucleocapsid)-gene of the hSARS virus. The present method eliminates false negative results and provides increased sensitivity for the assay. The invention also discloses the S (spike)-gene of the hSARS virus. The invention further relates to the deduced amino acid sequences of the N-gene and S-gene products of the hSARS virus and to the use of the N-gene and S-gene products in diagnostic methods. The invention further encompasses diagnostic assays and kits comprising antibodies generated against the N-gene or S-gene product.
 
DC FieldValue
dc.contributor.inventorChan, Kwok Hung
 
dc.contributor.inventorGuan, Yi
 
dc.contributor.inventorLeung, Frederick C C
 
dc.contributor.inventorNicholls, John Malcolm
 
dc.contributor.inventorPeiris, Joseph Sriyal Malik
 
dc.contributor.inventorPoon, Leo Lit Man
 
dc.contributor.inventorYuen, Kwok Yung
 
dc.date.accessioned2011-10-19T06:36:03Z
 
dc.date.available2011-10-19T06:36:03Z
 
patents.date.granted2010-06-16
 
dc.date.issued2010
 
dc.description.abstractThe present invention relates to a high-throughput diagnostic assay for the virus causing Severe Acute Respiratory Syndrome (SARS) in humans ('hSARS virus'). In particular, the invention relates to a high-throughput reverse transcription-PCR diagnostic test for SARS associated coronavirus (SARS-CoV). The present assay is a rapid, reliable assay which can be used for diagnosis and monitoring the spread of SARS and is based on the nucleotide sequences of the N (nucleocapsid)-gene of the hSARS virus. The present method eliminates false negative results and provides increased sensitivity for the assay. The invention also discloses the S (spike)-gene of the hSARS virus. The invention further relates to the deduced amino acid sequences of the N-gene and S-gene products of the hSARS virus and to the use of the N-gene and S-gene products in diagnostic methods. The invention further encompasses diagnostic assays and kits comprising antibodies generated against the N-gene or S-gene product.
 
patents.description.ccCN
 
patents.description.countryChina, PRC
 
patents.identifier.grantedZL200480007680.4
 
patents.identifier.hkutechidMicro-2003-00161
 
dc.identifier.urihttp://hdl.handle.net/10722/142238
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documents
 
dc.titleHigh-throughput Diagnostic Assay For THE Human Virus Causing Severe Acute Respiratory Syndrome (sars)
 
dc.typePatent
 
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<date.available>2011-10-19T06:36:03Z</date.available>
<date.issued>2010</date.issued>
<identifier.uri>http://hdl.handle.net/10722/142238</identifier.uri>
<description.abstract>The present invention relates to a high-throughput diagnostic assay for the virus causing Severe Acute Respiratory Syndrome (SARS) in humans (&apos;hSARS virus&apos;). In particular, the invention relates to a high-throughput reverse transcription-PCR diagnostic test for SARS associated coronavirus (SARS-CoV). The present assay is a rapid, reliable assay which can be used for diagnosis and monitoring the spread of SARS and is based on the nucleotide sequences of the N (nucleocapsid)-gene of the hSARS virus. The present method eliminates false negative results and provides increased sensitivity for the assay. The invention also discloses the S (spike)-gene of the hSARS virus. The invention further relates to the deduced amino acid sequences of the N-gene and S-gene products of the hSARS virus and to the use of the N-gene and S-gene products in diagnostic methods. The invention further encompasses diagnostic assays and kits comprising antibodies generated against the N-gene or S-gene product.</description.abstract>
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<title>High-throughput Diagnostic Assay For THE Human Virus Causing Severe Acute Respiratory Syndrome (sars)</title>
<type>Patent</type>
<contributor.inventor>Chan, Kwok Hung</contributor.inventor>
<contributor.inventor>Guan, Yi</contributor.inventor>
<contributor.inventor>Leung, Frederick C C</contributor.inventor>
<contributor.inventor>Nicholls, John Malcolm</contributor.inventor>
<contributor.inventor>Peiris, Joseph Sriyal Malik</contributor.inventor>
<contributor.inventor>Poon, Leo Lit Man</contributor.inventor>
<contributor.inventor>Yuen, Kwok Yung</contributor.inventor>
<patents.identifier.granted>ZL200480007680.4</patents.identifier.granted>
<patents.description.country>China, PRC</patents.description.country>
<patents.date.granted>2010-06-16</patents.date.granted>
<patents.identifier.hkutechid>Micro-2003-00161</patents.identifier.hkutechid>
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