Published Patent: Antibacterial Surface And Method Of Fabrication
| Title | Antibacterial Surface And Method Of Fabrication |
|---|---|
| Priority Date | 2010-02-16 US 12/706483 2009-02-19 US 12/153840P 2009-02-20 US 12/154278P |
| Inventors | Cheung, Kenneth Man Chee Kao, Richard Yi Tsun Luk, Keith Dip Kei Yeung, Che Yan Yeung, Kelvin Wai Kwok Chu, Paul Kim Ho |
| Citation | US Published patent application 20110046747. Washington, DC: US Patent and Trademark Office (USPTO), 2011 [How to Cite?] |
| Abstract | This Invention Involves A Plasma Treated And Controllable Release Antimicrobial Peptide Coated Titanium Alloy For Surgical Implantation, Where The Alloy With Antimicrobial Properties Is Fabricated Using Surface Techniques Without Adversely Compromising Its Biocompatibility And Original Mechanical Properties. The Surface Techniques Form Antimicrobial Layers On The Alloy Capable Of Resisting Microbial Adhesion And Proliferation, While Allowing Mammalian Cell Adhesion And Proliferation When The Alloy Is Implanted To Human Body. In One Embodiment, Piii&D Is Applied To Incorporate Ions, Electrons, Free Radicals, Atoms Or Molecules On A Titanium Alloy Substrate. A Pressurized Hydrothermal Treatment Can Be Carried Out To Establish Reactive Functional Groups For Antimicrobial Purpose Or For Connecting The Substrate And External Antimicrobial Molecules. An Outermost Layer Of The Titanium Alloy Includes Antibacterial Peptides Possessing A Controllable Release Mechanism, And Is Fabricated Alone Or In An Assembly Of The Aforementioned Basal Surface Layers. The Controllable Release Mechanism Is Able To Withstand Long-Term Deep Tissue Infection After Surgery, And In An Embodiment Comprises Aptes As A Linker Molecule. |
| References | US 5782908 (A) 1998-07-21 US 6183255 (B1) 2001-02-06 WO 2008068531 (A2) 2008-06-12 WO 2008068531 (A3) 2009-04-09 |
| dc.contributor.inventor | Cheung, Kenneth Man Chee |
|---|---|
| dc.contributor.inventor | Kao, Richard Yi Tsun |
| dc.contributor.inventor | Luk, Keith Dip Kei |
| dc.contributor.inventor | Yeung, Che Yan |
| dc.contributor.inventor | Yeung, Kelvin Wai Kwok |
| dc.contributor.inventor | Chu, Paul Kim Ho |
| dc.date.accessioned | 2011-10-19T06:32:54Z |
| patents.date.application | 2010-02-16 |
| dc.date.available | 2011-10-19T06:32:54Z |
| patents.date.priority | 2010-02-16 US 12/706483 |
| patents.date.priority | 2009-02-19 US 12/153840P |
| patents.date.priority | 2009-02-20 US 12/154278P |
| patents.date.publication | 2011-02-24 |
| dc.description.abstract | This Invention Involves A Plasma Treated And Controllable Release Antimicrobial Peptide Coated Titanium Alloy For Surgical Implantation, Where The Alloy With Antimicrobial Properties Is Fabricated Using Surface Techniques Without Adversely Compromising Its Biocompatibility And Original Mechanical Properties. The Surface Techniques Form Antimicrobial Layers On The Alloy Capable Of Resisting Microbial Adhesion And Proliferation, While Allowing Mammalian Cell Adhesion And Proliferation When The Alloy Is Implanted To Human Body. In One Embodiment, Piii&D Is Applied To Incorporate Ions, Electrons, Free Radicals, Atoms Or Molecules On A Titanium Alloy Substrate. A Pressurized Hydrothermal Treatment Can Be Carried Out To Establish Reactive Functional Groups For Antimicrobial Purpose Or For Connecting The Substrate And External Antimicrobial Molecules. An Outermost Layer Of The Titanium Alloy Includes Antibacterial Peptides Possessing A Controllable Release Mechanism, And Is Fabricated Alone Or In An Assembly Of The Aforementioned Basal Surface Layers. The Controllable Release Mechanism Is Able To Withstand Long-Term Deep Tissue Infection After Surgery, And In An Embodiment Comprises Aptes As A Linker Molecule. |
| patents.description.cc | US |
| patents.description.country | United States of America |
| patents.description.kind | A1 |
| dc.description.nature | link_to_OA_fulltext |
| patents.identifier.application | US 12/706483 |
| dc.identifier.citation | US Published patent application 20110046747. Washington, DC: US Patent and Trademark Office (USPTO), 2011 [How to Cite?] |
| patents.identifier.hkutechid | O&T-2009-00305 |
| patents.identifier.publication | US 20110046747 |
| dc.identifier.uri | http://hdl.handle.net/10722/142159 |
| patents.relation.family | CN 102341132 (A) 2012-02-01 |
| patents.relation.family | EP 2398517 (A2) 2011-12-28 |
| patents.relation.family | US 2011046747 (A1) 2011-02-24 |
| patents.relation.family | WO 2010094212 (A2) 2010-08-26 |
| dc.relation.references | US 5782908 (A) 1998-07-21 |
| dc.relation.references | US 6183255 (B1) 2001-02-06 |
| dc.relation.references | WO 2008068531 (A2) 2008-06-12 |
| dc.relation.references | WO 2008068531 (A3) 2009-04-09 |
| dc.rights | Creative Commons: Attribution 3.0 Hong Kong License For Public Patent Documents |
| dc.title | Antibacterial Surface And Method Of Fabrication |
| dc.type | Patent |
| patents.type | Patent_published |