Published Patent: Bioengineered Intervertebral Discs And Methods For Their Preparation

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TitleBioengineered Intervertebral Discs And Methods For Their Preparation
Priority Date2007-04-30 US /742040
2006-04-28 US 11/796088P
InventorsChan, Barbara Pui
Chan, Danny
Chan, Godfrey Chi Fung
Cheung, Kenneth Man Chee
Hui, Ting Yan
CitationUS Published patent application 20070292514. Washington, DC: US Patent and Trademark Office (USPTO), 2007 [How to Cite?]
AbstractA Bioengineered Ivd For Disc Replacement Has Been Developed That Has Mechanical And Structural Support Characteristics Similar To Those Of Native Ivd. Extracellular Matrix (Ecm) Provides Support To Living Cell Components And Interacts With The Living Cellular Components During The Fabrication Process Without Introducing Toxicity. The Composition Can Be Produced From Both Natural Or Synthetic Source But Preferably Natural And Induced To Self-Assemble Or Reconstitute Into Its Solid Form Under Conditions That Are Mild Enough To Support Cellular Survival And Growth. The Cells Induce A Volume Change Of The Structures, Leading To Changes In Dimension, Ecm Density, Cell Density Mechanical Property And Stability, Etc. The Extent Of The Change I Volume Of The Composition Can Be Precisely Controlled By Factors Such As The Density Of The Ecm, The Density Of The Living Cells, The Timing For Interaction And The Serum Concentration. Increased Structural Support Is Provided By Crosslinking.
DC Field
Value
dc.contributor.inventorChan, Barbara Pui
dc.contributor.inventorChan, Danny
dc.contributor.inventorChan, Godfrey Chi Fung
dc.contributor.inventorCheung, Kenneth Man Chee
dc.contributor.inventorHui, Ting Yan
dc.date.accessioned2011-10-19T06:29:14Z
patents.date.application2007-04-30
dc.date.available2011-10-19T06:29:14Z
patents.date.priority2007-04-30 US /742040
patents.date.priority2006-04-28 US 11/796088P
patents.date.publication2007-12-20
dc.description.abstractA Bioengineered Ivd For Disc Replacement Has Been Developed That Has Mechanical And Structural Support Characteristics Similar To Those Of Native Ivd. Extracellular Matrix (Ecm) Provides Support To Living Cell Components And Interacts With The Living Cellular Components During The Fabrication Process Without Introducing Toxicity. The Composition Can Be Produced From Both Natural Or Synthetic Source But Preferably Natural And Induced To Self-Assemble Or Reconstitute Into Its Solid Form Under Conditions That Are Mild Enough To Support Cellular Survival And Growth. The Cells Induce A Volume Change Of The Structures, Leading To Changes In Dimension, Ecm Density, Cell Density Mechanical Property And Stability, Etc. The Extent Of The Change I Volume Of The Composition Can Be Precisely Controlled By Factors Such As The Density Of The Ecm, The Density Of The Living Cells, The Timing For Interaction And The Serum Concentration. Increased Structural Support Is Provided By Crosslinking.
patents.description.assigneeUniv Hong Kong
patents.description.ccUS
patents.description.countryUnited States of America
patents.description.kindA1
dc.description.naturelink_to_OA_fulltext
patents.identifier.applicationUS /742040
dc.identifier.citationUS Published patent application 20070292514. Washington, DC: US Patent and Trademark Office (USPTO), 2007 [How to Cite?]
patents.identifier.hkutechidME-2006-00207
patents.identifier.publicationUS 20070292514
dc.identifier.urihttp://hdl.handle.net/10722/142074
patents.relation.familyCN 101478934 (A) 2009-07-08
patents.relation.familyEP 2019653 (A2) 2009-02-04
patents.relation.familyUS 2007292514 (A1) 2007-12-20
patents.relation.familyWO 2008078157 (A2) 2008-07-03
dc.relation.isreferencedbyWO 2009142770 (A2) 2009-11-26
dc.relation.isreferencedbyWO 2009142770 (A3) 2010-01-14
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documents
dc.titleBioengineered Intervertebral Discs And Methods For Their Preparation
dc.typePatent
patents.typePatent_published