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Article: Molecular epidemiology of H5N1 avian influenza

TitleMolecular epidemiology of H5N1 avian influenza
Authors
KeywordsAvian influenza
Dissemination
H5N1
Highly pathogenic avian influenza
Molecular evolution
Pandemic potential
Issue Date2009
PublisherOrganisation Mondiale de la Sante Animale (O I E). The Journal's web site is located at http://www.oie.int
Citation
Oie Revue Scientifique Et Technique, 2009, v. 28 n. 1, p. 39-47 How to Cite?
AbstractThe highly pathogenic Asian H5N1 influenza virus that was first detected in Guangdong in the People's Republic of China (China) in 1996 is unique in having spread to humans and other mammalian species. To date, this virus has not consistently transmitted between any mammalian species but the continued spread and evolution of these viruses in domestic poultry across Eurasia presents a continuing pandemic threat. These viruses have caused devastation in domestic poultry and have killed over 60% of infected humans. The H5N1 viruses are unique in having evolved into multiple clades and subclades by reassortment with other influenza viruses in the epicentre of southern China, and accumulation of point mutations has resulted in antigenic differences between the clades. Three waves of spread have occurred, wave one to East Asia and Southeast Asia, wave two through Qinghai Lake, China, to Europe, India and Africa, and wave three to Southeast Asia again. This paper deals with the molecular epidemiology of the evolution of the multiplicity of H5N1 clades. The continuing evolution of these H5N1 viruses and the possible establishment of secondary epicentres in Indonesia, Egypt and Nigeria present a continuing threat to poultry and people globally.
Persistent Identifierhttp://hdl.handle.net/10722/141982
ISSN
2015 Impact Factor: 0.904
2015 SCImago Journal Rankings: 0.546
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorSmith, GJDen_HK
dc.contributor.authorWebby, Ren_HK
dc.contributor.authorWebster, RGen_HK
dc.date.accessioned2011-10-03T04:13:15Z-
dc.date.available2011-10-03T04:13:15Z-
dc.date.issued2009en_HK
dc.identifier.citationOie Revue Scientifique Et Technique, 2009, v. 28 n. 1, p. 39-47en_HK
dc.identifier.issn0253-1933en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141982-
dc.description.abstractThe highly pathogenic Asian H5N1 influenza virus that was first detected in Guangdong in the People's Republic of China (China) in 1996 is unique in having spread to humans and other mammalian species. To date, this virus has not consistently transmitted between any mammalian species but the continued spread and evolution of these viruses in domestic poultry across Eurasia presents a continuing pandemic threat. These viruses have caused devastation in domestic poultry and have killed over 60% of infected humans. The H5N1 viruses are unique in having evolved into multiple clades and subclades by reassortment with other influenza viruses in the epicentre of southern China, and accumulation of point mutations has resulted in antigenic differences between the clades. Three waves of spread have occurred, wave one to East Asia and Southeast Asia, wave two through Qinghai Lake, China, to Europe, India and Africa, and wave three to Southeast Asia again. This paper deals with the molecular epidemiology of the evolution of the multiplicity of H5N1 clades. The continuing evolution of these H5N1 viruses and the possible establishment of secondary epicentres in Indonesia, Egypt and Nigeria present a continuing threat to poultry and people globally.en_HK
dc.languageeng-
dc.publisherOrganisation Mondiale de la Sante Animale (O I E). The Journal's web site is located at http://www.oie.inten_HK
dc.relation.ispartofOIE Revue Scientifique et Techniqueen_HK
dc.subjectAvian influenzaen_HK
dc.subjectDisseminationen_HK
dc.subjectH5N1en_HK
dc.subjectHighly pathogenic avian influenzaen_HK
dc.subjectMolecular evolutionen_HK
dc.subjectPandemic potentialen_HK
dc.subject.meshInfluenza A Virus, H5N1 Subtype - classification - genetics - pathogenicity-
dc.subject.meshInfluenza in Birds - epidemiology - virology-
dc.subject.meshInfluenza, Human - epidemiology - virology-
dc.subject.meshMolecular Epidemiology-
dc.subject.meshPoultry-
dc.titleMolecular epidemiology of H5N1 avian influenzaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0253-1933&volume=28&issue=1&spage=39&epage=47&date=2009&atitle=Molecular+epidemiology+of+H5N1+avian+influenza-
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.emailSmith, GJD: gjsmith@hkucc1.hku.hken_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.identifier.authoritySmith, GJD=rp00444en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid19618617en_HK
dc.identifier.scopuseid_2-s2.0-68149170711en_HK
dc.identifier.hkuros196832-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-68149170711&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue1en_HK
dc.identifier.spage39en_HK
dc.identifier.epage47en_HK
dc.identifier.isiWOS:000267386500004-
dc.publisher.placeFranceen_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.scopusauthoridSmith, GJD=8344015800en_HK
dc.identifier.scopusauthoridWebby, R=35448064800en_HK
dc.identifier.scopusauthoridWebster, RG=36048363100en_HK

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