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Article: Multilevel modeling of cognitive function in schizophrenic patients and their first degree relatives

TitleMultilevel modeling of cognitive function in schizophrenic patients and their first degree relatives
Authors
Issue Date2001
PublisherLawrence Erlbaum Associates, Inc. The Journal's web site is located at http://www.leaonline.com/loi/mbr
Citation
Multivariate Behavioral Research, 2001, v. 36 n. 2, p. 279-298 How to Cite?
AbstractWe describe multilevel modeling of cognitive function in subjects with schizophrenia, their healthy first degree relatives and controls. The purpose of the study was to compare mean cognitive performance between the three groups after adjusting for various covariates, as well as to investigate differences in the variances. Multilevel models were required because subjects were nested within families and some of the measures were repeated several times on the same subject. The following four methodological issues that arose during the analysis of the data are discussed. First, when the random effects distribution was not normal, non-parametric maximum likelihood (NPML) was employed, leading to a different conclusion than the conventional multilevel model regarding one of the main study hypotheses. Second, the between-subject (within-family) variance was allowed to differ between the three groups. This corresponded to the variance at level 1 or level 2 depending on whether repeated measures were analyzed. Third, a positively skewed response was analyzed using a number of different generalized linear mixed models. Finally, penalized quasilikelihood (PQL) estimates for a binomial response were compared with estimates obtained using Gaussian quadrature. A small simulation study was carried out to assess the accuracy of the latter.
Persistent Identifierhttp://hdl.handle.net/10722/141876
ISSN
2015 Impact Factor: 1.551
2015 SCImago Journal Rankings: 2.431
References

 

DC FieldValueLanguage
dc.contributor.authorRabeHesketh, Sen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorMurray, RMen_HK
dc.date.accessioned2011-09-27T03:03:45Z-
dc.date.available2011-09-27T03:03:45Z-
dc.date.issued2001en_HK
dc.identifier.citationMultivariate Behavioral Research, 2001, v. 36 n. 2, p. 279-298en_HK
dc.identifier.issn0027-3171en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141876-
dc.description.abstractWe describe multilevel modeling of cognitive function in subjects with schizophrenia, their healthy first degree relatives and controls. The purpose of the study was to compare mean cognitive performance between the three groups after adjusting for various covariates, as well as to investigate differences in the variances. Multilevel models were required because subjects were nested within families and some of the measures were repeated several times on the same subject. The following four methodological issues that arose during the analysis of the data are discussed. First, when the random effects distribution was not normal, non-parametric maximum likelihood (NPML) was employed, leading to a different conclusion than the conventional multilevel model regarding one of the main study hypotheses. Second, the between-subject (within-family) variance was allowed to differ between the three groups. This corresponded to the variance at level 1 or level 2 depending on whether repeated measures were analyzed. Third, a positively skewed response was analyzed using a number of different generalized linear mixed models. Finally, penalized quasilikelihood (PQL) estimates for a binomial response were compared with estimates obtained using Gaussian quadrature. A small simulation study was carried out to assess the accuracy of the latter.en_HK
dc.languageengen_US
dc.publisherLawrence Erlbaum Associates, Inc. The Journal's web site is located at http://www.leaonline.com/loi/mbren_HK
dc.relation.ispartofMultivariate Behavioral Researchen_HK
dc.titleMultilevel modeling of cognitive function in schizophrenic patients and their first degree relativesen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0035535605en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035535605&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume36en_HK
dc.identifier.issue2en_HK
dc.identifier.spage279en_HK
dc.identifier.epage298en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridRabeHesketh, S=7003779088en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK

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