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Article: Brain volumes in familial and non-familial schizophrenic probands and their unaffected relatives

TitleBrain volumes in familial and non-familial schizophrenic probands and their unaffected relatives
Authors
KeywordsEndophenotypes
Family study
MRI
Obstetric complications
Schizophrenia
Issue Date2002
PublisherJohn Wiley & Sons, Inc
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 2002, v. 114 n. 6, p. 616-625 How to Cite?
AbstractStructural brain abnormalities are consistently reported in schizophrenic subjects but the etiology of these abnormalities remains unclear. We tested the contribution of genetic predisposition and obstetric complications to the structural brain abnormalities found in schizophrenic probands and their relatives. MRI scans were carried out on 35 schizophrenic probands from families multiply affected with the disorder, and 63 of their unaffected relatives, including 10 parents who appeared to transmit genetic risk to their children; as well as 31 schizophrenic probands from families with no other affected members, 33 of their unaffected relatives; and finally 68 controls. Volumetric measurements of whole brain, lateral ventricles, third ventricle, cerebellum, and temporal lobes were completed for each subject. The impact of obstetric complications on brain structure was assessed across the gradient of presumed genetic predisposition. Both groups of schizophrenic probands displayed enlargement of the lateral and third ventricles, and there was a gradient of ventricular enlargement amongst the unaffected relatives in proportion to their likelihood of carrying schizophrenic genes. Ventricular enlargement was largely confined to males in both probands and unaffected relatives. Obstetric complications were associated with ventricular enlargement only in the familial probands. Non-familial probands displayed reduced volume of the temporal lobes bilaterally. In families with several schizophrenic members, ventricular enlargement is a marker for genetic liability, particularly in males. Individuals inheriting the susceptibility to schizophrenia appear particularly prone to develop ventricular enlargement in response to obstetric complications. © 2002 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/141875
ISSN
2003 Impact Factor: -999.999
2009 SCImago Journal Rankings: 1.100
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMcDonald, Cen_HK
dc.contributor.authorGrech, Aen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorSchulze, Ken_HK
dc.contributor.authorChapple, Ben_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorWalshe, Men_HK
dc.contributor.authorSharma, Ten_HK
dc.contributor.authorSigmundsson, Ten_HK
dc.contributor.authorChitnis, Xen_HK
dc.contributor.authorMurray, RMen_HK
dc.date.accessioned2011-09-27T03:03:44Z-
dc.date.available2011-09-27T03:03:44Z-
dc.date.issued2002en_HK
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 2002, v. 114 n. 6, p. 616-625en_HK
dc.identifier.issn0148-7299en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141875-
dc.description.abstractStructural brain abnormalities are consistently reported in schizophrenic subjects but the etiology of these abnormalities remains unclear. We tested the contribution of genetic predisposition and obstetric complications to the structural brain abnormalities found in schizophrenic probands and their relatives. MRI scans were carried out on 35 schizophrenic probands from families multiply affected with the disorder, and 63 of their unaffected relatives, including 10 parents who appeared to transmit genetic risk to their children; as well as 31 schizophrenic probands from families with no other affected members, 33 of their unaffected relatives; and finally 68 controls. Volumetric measurements of whole brain, lateral ventricles, third ventricle, cerebellum, and temporal lobes were completed for each subject. The impact of obstetric complications on brain structure was assessed across the gradient of presumed genetic predisposition. Both groups of schizophrenic probands displayed enlargement of the lateral and third ventricles, and there was a gradient of ventricular enlargement amongst the unaffected relatives in proportion to their likelihood of carrying schizophrenic genes. Ventricular enlargement was largely confined to males in both probands and unaffected relatives. Obstetric complications were associated with ventricular enlargement only in the familial probands. Non-familial probands displayed reduced volume of the temporal lobes bilaterally. In families with several schizophrenic members, ventricular enlargement is a marker for genetic liability, particularly in males. Individuals inheriting the susceptibility to schizophrenia appear particularly prone to develop ventricular enlargement in response to obstetric complications. © 2002 Wiley-Liss, Inc.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Incen_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_HK
dc.subjectEndophenotypesen_HK
dc.subjectFamily studyen_HK
dc.subjectMRIen_HK
dc.subjectObstetric complicationsen_HK
dc.subjectSchizophreniaen_HK
dc.titleBrain volumes in familial and non-familial schizophrenic probands and their unaffected relativesen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T: timothea@hku.hken_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ajmg.10604en_HK
dc.identifier.pmid12210275-
dc.identifier.scopuseid_2-s2.0-0037044001en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037044001&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume114en_HK
dc.identifier.issue6en_HK
dc.identifier.spage616en_HK
dc.identifier.epage625en_HK
dc.identifier.isiWOS:000177185400005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMcDonald, C=8749594800en_HK
dc.identifier.scopusauthoridGrech, A=6602744459en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridSchulze, K=7103137549en_HK
dc.identifier.scopusauthoridChapple, B=6603274265en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridWalshe, M=8855469300en_HK
dc.identifier.scopusauthoridSharma, T=7202571892en_HK
dc.identifier.scopusauthoridSigmundsson, T=6602171613en_HK
dc.identifier.scopusauthoridChitnis, X=6602314186en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK

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