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Article: Selectivity of verbal memory deficit in schizophrenic patients and their relatives

TitleSelectivity of verbal memory deficit in schizophrenic patients and their relatives
Authors
KeywordsCognitive impairment
Executive processes
Genetic liability
Relatives
Schizophrenia
Selective deficits
Verbal memory
Visual memory
Issue Date2003
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 2003, v. 116 B n. 1, p. 1-7 How to Cite?
AbstractSome of the relatives of people with schizophrenia show impairments of memory and executive function. It is not known, however, whether within these domains there is a class of processes that is especially impaired. Seventy schizophrenic or schizoaffective patients, 115 of their relatives and 66 normal controls underwent a series of assessments evaluating modality specific recall/learning, and aspects of executive functioning, including, planning ability, spatial working memory, strategy formation and rapid mental flexibility. The pattern of performance across cognitive processes was assessed using z-scores that allow direct comparison between tests with different raw score metrics. Selectivity of deficit was evaluated by subtracting the z-score of each cognitive process from the mean of the z-scores of those remaining. Patients performed worse than controls on most measures, with verbal immediate recall and visual memory/learning the most impaired. Their relatives showed lower scores than controls on verbal and visual memory/ learning and strategy formation; verbal memory and strategy formation remained impaired after eliminating those relatives with a psychiatric diagnosis. Consistent with the findings in their schizophrenic kin, healthy relatives also showed disproportionate impairments in verbal immediate recall. Our finding of a selective deficit in verbal memory among relatives suggests that such impairment constitutes a familial, probably genetic, risk factor for schizophrenia. © 2003 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/141874
ISSN
2015 Impact Factor: 3.391
2015 SCImago Journal Rankings: 1.771
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorMorris, RGen_HK
dc.contributor.authorRabeHesketh, Sen_HK
dc.contributor.authorMurray, RMen_HK
dc.date.accessioned2011-09-27T03:03:42Z-
dc.date.available2011-09-27T03:03:42Z-
dc.date.issued2003en_HK
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 2003, v. 116 B n. 1, p. 1-7en_HK
dc.identifier.issn1552-4841en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141874-
dc.description.abstractSome of the relatives of people with schizophrenia show impairments of memory and executive function. It is not known, however, whether within these domains there is a class of processes that is especially impaired. Seventy schizophrenic or schizoaffective patients, 115 of their relatives and 66 normal controls underwent a series of assessments evaluating modality specific recall/learning, and aspects of executive functioning, including, planning ability, spatial working memory, strategy formation and rapid mental flexibility. The pattern of performance across cognitive processes was assessed using z-scores that allow direct comparison between tests with different raw score metrics. Selectivity of deficit was evaluated by subtracting the z-score of each cognitive process from the mean of the z-scores of those remaining. Patients performed worse than controls on most measures, with verbal immediate recall and visual memory/learning the most impaired. Their relatives showed lower scores than controls on verbal and visual memory/ learning and strategy formation; verbal memory and strategy formation remained impaired after eliminating those relatives with a psychiatric diagnosis. Consistent with the findings in their schizophrenic kin, healthy relatives also showed disproportionate impairments in verbal immediate recall. Our finding of a selective deficit in verbal memory among relatives suggests that such impairment constitutes a familial, probably genetic, risk factor for schizophrenia. © 2003 Wiley-Liss, Inc.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/en_HK
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_HK
dc.subjectCognitive impairmenten_HK
dc.subjectExecutive processesen_HK
dc.subjectGenetic liabilityen_HK
dc.subjectRelativesen_HK
dc.subjectSchizophreniaen_HK
dc.subjectSelective deficitsen_HK
dc.subjectVerbal memoryen_HK
dc.subjectVisual memoryen_HK
dc.titleSelectivity of verbal memory deficit in schizophrenic patients and their relativesen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid12497605-
dc.identifier.scopuseid_2-s2.0-0042827441en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0042827441&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume116 Ben_HK
dc.identifier.issue1en_HK
dc.identifier.spage1en_HK
dc.identifier.epage7en_HK
dc.identifier.isiWOS:000182399800001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridMorris, RG=7404060505en_HK
dc.identifier.scopusauthoridRabeHesketh, S=7003779088en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK

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