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Article: Hippocampal volume in familial and nonfamilial schizophrenic probands and their unaffected relatives

TitleHippocampal volume in familial and nonfamilial schizophrenic probands and their unaffected relatives
Authors
KeywordsFamily study
Hippocampus
MRI
Obstetric complications
Relatives
Schizophrenia
Issue Date2003
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiat
Citation
Biological Psychiatry, 2003, v. 53 n. 7, p. 562-570 How to Cite?
AbstractBackground: There is evidence for hippocampal volume loss in schizophrenia, but the etiology of this remains unclear. The aim of our study was to assess the contribution of familial liability and obstetric complications to hippocampal volume reduction in schizophrenia. Methods: Hippocampal volumes were obtained using stereological methods from magnetic resonance scans performed on 35 schizophrenic probands from multiply affected families and 63 of their unaffected relatives, as well as 31 schizophrenic probands from families with no other affected members, 33 of their unaffected relatives, and 68 control subjects. Results: Probands with schizophrenia, regardless of family history, had significant volume reduction of the left hippocampus. Hippocampal volume was not significantly reduced in either group of relatives. Obstetric complications were associated with left hippocampal volume reduction. Conclusions: We failed to find evidence that hippocampal volume loss is associated with familial liability to schizophrenia but have confirmed the association between hippocampal volume reduction and exposure to obstetric complications. © 2003 Society of Biological Psychiatry.
Persistent Identifierhttp://hdl.handle.net/10722/141873
ISSN
2015 Impact Factor: 11.212
2015 SCImago Journal Rankings: 5.823
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSchulze, Ken_HK
dc.contributor.authorMcDonald, Cen_HK
dc.contributor.authorFrangou, Sen_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorGrech, Aen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorWalshe, Men_HK
dc.contributor.authorSharma, Ten_HK
dc.contributor.authorSigmundsson, Ten_HK
dc.contributor.authorTaylor, Men_HK
dc.contributor.authorMurray, RMen_HK
dc.date.accessioned2011-09-27T03:03:42Z-
dc.date.available2011-09-27T03:03:42Z-
dc.date.issued2003en_HK
dc.identifier.citationBiological Psychiatry, 2003, v. 53 n. 7, p. 562-570en_HK
dc.identifier.issn0006-3223en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141873-
dc.description.abstractBackground: There is evidence for hippocampal volume loss in schizophrenia, but the etiology of this remains unclear. The aim of our study was to assess the contribution of familial liability and obstetric complications to hippocampal volume reduction in schizophrenia. Methods: Hippocampal volumes were obtained using stereological methods from magnetic resonance scans performed on 35 schizophrenic probands from multiply affected families and 63 of their unaffected relatives, as well as 31 schizophrenic probands from families with no other affected members, 33 of their unaffected relatives, and 68 control subjects. Results: Probands with schizophrenia, regardless of family history, had significant volume reduction of the left hippocampus. Hippocampal volume was not significantly reduced in either group of relatives. Obstetric complications were associated with left hippocampal volume reduction. Conclusions: We failed to find evidence that hippocampal volume loss is associated with familial liability to schizophrenia but have confirmed the association between hippocampal volume reduction and exposure to obstetric complications. © 2003 Society of Biological Psychiatry.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiaten_HK
dc.relation.ispartofBiological Psychiatryen_HK
dc.subjectFamily studyen_HK
dc.subjectHippocampusen_HK
dc.subjectMRIen_HK
dc.subjectObstetric complicationsen_HK
dc.subjectRelativesen_HK
dc.subjectSchizophreniaen_HK
dc.titleHippocampal volume in familial and nonfamilial schizophrenic probands and their unaffected relativesen_HK
dc.typeArticleen_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.emailToulopoulou, T: timothea@hku.hken_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0006-3223(02)01910-8en_HK
dc.identifier.pmid12679233-
dc.identifier.scopuseid_2-s2.0-12244304859en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-12244304859&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume53en_HK
dc.identifier.issue7en_HK
dc.identifier.spage562en_HK
dc.identifier.epage570en_HK
dc.identifier.isiWOS:000181997200002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSchulze, K=7103137549en_HK
dc.identifier.scopusauthoridMcDonald, C=8749594800en_HK
dc.identifier.scopusauthoridFrangou, S=7004549374en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridGrech, A=6602744459en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridWalshe, M=8855469300en_HK
dc.identifier.scopusauthoridSharma, T=7202571892en_HK
dc.identifier.scopusauthoridSigmundsson, T=6602171613en_HK
dc.identifier.scopusauthoridTaylor, M=35556198800en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK

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