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Article: Episodic memory in schizophrenic patients and their relatives

TitleEpisodic memory in schizophrenic patients and their relatives
Authors
KeywordsCognitive dysfunction
Genetic liability
Relatives
Verbal memory
Visual memory
Issue Date2003
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2003, v. 63 n. 3, p. 261-271 How to Cite?
AbstractBackground: Memory dysfunction among healthy relatives of patients with schizophrenia suggests that genetic liability to the disorder can also be manifested as cognitive impairment. This study was designed to further elucidate the nature of the memory dysfunction being transmitted. Method: Memory function was assessed in 62 schizophrenic patients, 98 of their healthy relatives and 66 controls. Material-specific immediate/delayed recall and percentage retention were investigated using the Logical Memory and Visual Reproduction tests of the Wechsler Memory Scale (WMS). A third subtest of the WMS, the Associate Learning and a visual analogue of it, the Abstract Paired Associates, were used to measure verbal and visual learning. Current general intellectual function was assessed using a five-subtest short-form of the Wechsler Adult Intelligence scale - Revised (WAIS-R). Results: Schizophrenic patients performed significantly worse than controls on nearly all measures. Their relatives also showed significant deficit on the immediate and delayed recall of the Logical Memory, immediate recall of the Visual Reproduction, and the Abstract Paired Associates tests. Logical memory was substantially more impaired than the other measures for both patients and relatives. The deficit in immediate recall of the Logical Memory remained significant even after excluding those relatives with an Axis I diagnosis and schizotypal personality disorder. These findings were despite the relatives having an equivalent level of general intellectual function to that of controls. Conclusion: Familial, presumed genetic, liability to schizophrenia may be expressed as dysfunction in verbal memory. © 2002 Elsevier Science B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/141872
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorRabeHesketh, Sen_HK
dc.contributor.authorKing, Hen_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorMorris, RGen_HK
dc.date.accessioned2011-09-27T03:03:40Z-
dc.date.available2011-09-27T03:03:40Z-
dc.date.issued2003en_HK
dc.identifier.citationSchizophrenia Research, 2003, v. 63 n. 3, p. 261-271en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141872-
dc.description.abstractBackground: Memory dysfunction among healthy relatives of patients with schizophrenia suggests that genetic liability to the disorder can also be manifested as cognitive impairment. This study was designed to further elucidate the nature of the memory dysfunction being transmitted. Method: Memory function was assessed in 62 schizophrenic patients, 98 of their healthy relatives and 66 controls. Material-specific immediate/delayed recall and percentage retention were investigated using the Logical Memory and Visual Reproduction tests of the Wechsler Memory Scale (WMS). A third subtest of the WMS, the Associate Learning and a visual analogue of it, the Abstract Paired Associates, were used to measure verbal and visual learning. Current general intellectual function was assessed using a five-subtest short-form of the Wechsler Adult Intelligence scale - Revised (WAIS-R). Results: Schizophrenic patients performed significantly worse than controls on nearly all measures. Their relatives also showed significant deficit on the immediate and delayed recall of the Logical Memory, immediate recall of the Visual Reproduction, and the Abstract Paired Associates tests. Logical memory was substantially more impaired than the other measures for both patients and relatives. The deficit in immediate recall of the Logical Memory remained significant even after excluding those relatives with an Axis I diagnosis and schizotypal personality disorder. These findings were despite the relatives having an equivalent level of general intellectual function to that of controls. Conclusion: Familial, presumed genetic, liability to schizophrenia may be expressed as dysfunction in verbal memory. © 2002 Elsevier Science B.V. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.subjectCognitive dysfunctionen_HK
dc.subjectGenetic liabilityen_HK
dc.subjectRelativesen_HK
dc.subjectVerbal memoryen_HK
dc.subjectVisual memoryen_HK
dc.titleEpisodic memory in schizophrenic patients and their relativesen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0920-9964(02)00324-9en_HK
dc.identifier.pmid12957705-
dc.identifier.scopuseid_2-s2.0-0041326810en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0041326810&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume63en_HK
dc.identifier.issue3en_HK
dc.identifier.spage261en_HK
dc.identifier.epage271en_HK
dc.identifier.isiWOS:000185376800006-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridRabeHesketh, S=7003779088en_HK
dc.identifier.scopusauthoridKing, H=37052269600en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridMorris, RG=7404060505en_HK

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