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Article: Normal cerebral asymmetry in familial and non-familial schizophrenic probands and their unaffected relatives

TitleNormal cerebral asymmetry in familial and non-familial schizophrenic probands and their unaffected relatives
Authors
KeywordsCerebral asymmetry
Family study
MRI
Schizophrenia
Torque
Issue Date2004
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2004, v. 67 n. 1, p. 33-40 How to Cite?
AbstractLoss of normal fronto-occipital cerebral asymmetry has been reported in patients with schizophrenia and also in their well relatives from multiply affected families, suggesting a relationship with susceptibility genes. We sought to confirm this relationship in a family study of patients with schizophrenia and their unaffected relatives of presumed differing genetic risk. MRI scans were carried out on 25 probands from families multiply affected with the disorder, and 36 of their unaffected relatives, 34 probands from families with no other affected members, 42 of their unaffected relatives, and 76 controls. Volumetric measurements of prefrontal, premotor, sensorimotor and occipitoparietal regions were obtained from which a measure of fronto-occipital torque was derived. There were no significant differences in measurements of fronto-occipital torque between the subject groups. Both schizophrenic probands and their relatives displayed the normal pattern of cerebral asymmetry, with larger right than left frontal regions and a larger left than right occipitoparietal region. Our findings failed to confirm an association between loss of fronto-occipital torque and genetic liability for schizophrenia and also failed to replicate the previously reported association between loss/reversal of fronto-occipital asymmetry and schizophrenia. © 2003 Elsevier Science B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/141870
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChapple, Ben_HK
dc.contributor.authorGrech, Aen_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorWalshe, Men_HK
dc.contributor.authorSchulze, Ken_HK
dc.contributor.authorMorgan, Ken_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorMcDonald, Cen_HK
dc.date.accessioned2011-09-27T03:03:39Z-
dc.date.available2011-09-27T03:03:39Z-
dc.date.issued2004en_HK
dc.identifier.citationSchizophrenia Research, 2004, v. 67 n. 1, p. 33-40en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141870-
dc.description.abstractLoss of normal fronto-occipital cerebral asymmetry has been reported in patients with schizophrenia and also in their well relatives from multiply affected families, suggesting a relationship with susceptibility genes. We sought to confirm this relationship in a family study of patients with schizophrenia and their unaffected relatives of presumed differing genetic risk. MRI scans were carried out on 25 probands from families multiply affected with the disorder, and 36 of their unaffected relatives, 34 probands from families with no other affected members, 42 of their unaffected relatives, and 76 controls. Volumetric measurements of prefrontal, premotor, sensorimotor and occipitoparietal regions were obtained from which a measure of fronto-occipital torque was derived. There were no significant differences in measurements of fronto-occipital torque between the subject groups. Both schizophrenic probands and their relatives displayed the normal pattern of cerebral asymmetry, with larger right than left frontal regions and a larger left than right occipitoparietal region. Our findings failed to confirm an association between loss of fronto-occipital torque and genetic liability for schizophrenia and also failed to replicate the previously reported association between loss/reversal of fronto-occipital asymmetry and schizophrenia. © 2003 Elsevier Science B.V. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.subjectCerebral asymmetryen_HK
dc.subjectFamily studyen_HK
dc.subjectMRIen_HK
dc.subjectSchizophreniaen_HK
dc.subjectTorqueen_HK
dc.titleNormal cerebral asymmetry in familial and non-familial schizophrenic probands and their unaffected relativesen_HK
dc.typeArticleen_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.emailToulopoulou, T: timothea@hku.hken_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0920-9964(03)00095-1en_HK
dc.identifier.pmid14741322-
dc.identifier.scopuseid_2-s2.0-1642483064en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1642483064&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume67en_HK
dc.identifier.issue1en_HK
dc.identifier.spage33en_HK
dc.identifier.epage40en_HK
dc.identifier.isiWOS:000188738800004-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridChapple, B=6603274265en_HK
dc.identifier.scopusauthoridGrech, A=6602744459en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridWalshe, M=8855469300en_HK
dc.identifier.scopusauthoridSchulze, K=7103137549en_HK
dc.identifier.scopusauthoridMorgan, K=7401575547en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridMcDonald, C=8749594800en_HK

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