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Article: The relationship between volumetric brain changes and cognitive function: A family study on schizophrenia

TitleThe relationship between volumetric brain changes and cognitive function: A family study on schizophrenia
Authors
KeywordsCognition
executive processing
intelligence
intelligence quotient
magnetic resonance imaging
memory
Issue Date2004
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiat
Citation
Biological Psychiatry, 2004, v. 56 n. 6, p. 447-453 How to Cite?
AbstractWe examined the cerebral correlates of intelligence, memory, and executive processing in 56 patients with schizophrenia or schizoaffective disorder and 90 of their nonpsychotic relatives to establish whether the pattern of structure-function relationships in these two groups was different from that in 55 control subjects. Magnetic resonance imaging data were acquired, and volumetric measurements were made for whole brain, prefrontal region, lateral ventricles, third ventricle, temporal lobes, hippocampi, and cerebellum. In the total sample, full intelligence quotient (IQ) and verbal IQ correlated with the volume of the whole brain and right hippocampus; the latter was also associated with performance IQ. Left hippocampal size was associated with verbal IQ and, in control subjects and nonpsychotic relatives only, with estimated full IQ. Delayed verbal memory was linked to cerebellar and inversely to left hippocampal volume. Discrepancies in the relationship pattern emerged in patients with schizophrenia between left hippocampus and measures of IQ and verbal memory. The latter data indicate a loss of a normal structure-function relationship in schizophrenia and might reflect a functional compensation occurring secondary to early neurodevelopmental impairment.
Persistent Identifierhttp://hdl.handle.net/10722/141869
ISSN
2015 Impact Factor: 11.212
2015 SCImago Journal Rankings: 5.823
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorGrech, Aen_HK
dc.contributor.authorMorris, RGen_HK
dc.contributor.authorSchulze, Ken_HK
dc.contributor.authorMcDonald, Cen_HK
dc.contributor.authorChapple, Ben_HK
dc.contributor.authorRabeHesketh, Sen_HK
dc.contributor.authorMurray, RMen_HK
dc.date.accessioned2011-09-27T03:03:37Z-
dc.date.available2011-09-27T03:03:37Z-
dc.date.issued2004en_HK
dc.identifier.citationBiological Psychiatry, 2004, v. 56 n. 6, p. 447-453en_HK
dc.identifier.issn0006-3223en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141869-
dc.description.abstractWe examined the cerebral correlates of intelligence, memory, and executive processing in 56 patients with schizophrenia or schizoaffective disorder and 90 of their nonpsychotic relatives to establish whether the pattern of structure-function relationships in these two groups was different from that in 55 control subjects. Magnetic resonance imaging data were acquired, and volumetric measurements were made for whole brain, prefrontal region, lateral ventricles, third ventricle, temporal lobes, hippocampi, and cerebellum. In the total sample, full intelligence quotient (IQ) and verbal IQ correlated with the volume of the whole brain and right hippocampus; the latter was also associated with performance IQ. Left hippocampal size was associated with verbal IQ and, in control subjects and nonpsychotic relatives only, with estimated full IQ. Delayed verbal memory was linked to cerebellar and inversely to left hippocampal volume. Discrepancies in the relationship pattern emerged in patients with schizophrenia between left hippocampus and measures of IQ and verbal memory. The latter data indicate a loss of a normal structure-function relationship in schizophrenia and might reflect a functional compensation occurring secondary to early neurodevelopmental impairment.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiaten_HK
dc.relation.ispartofBiological Psychiatryen_HK
dc.subjectCognitionen_HK
dc.subjectexecutive processingen_HK
dc.subjectintelligenceen_HK
dc.subjectintelligence quotienten_HK
dc.subjectmagnetic resonance imagingen_HK
dc.subjectmemoryen_HK
dc.titleThe relationship between volumetric brain changes and cognitive function: A family study on schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.biopsych.2004.06.026en_HK
dc.identifier.pmid15364043-
dc.identifier.scopuseid_2-s2.0-4444250625en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4444250625&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume56en_HK
dc.identifier.issue6en_HK
dc.identifier.spage447en_HK
dc.identifier.epage453en_HK
dc.identifier.isiWOS:000223855200010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridGrech, A=6602744459en_HK
dc.identifier.scopusauthoridMorris, RG=7404060505en_HK
dc.identifier.scopusauthoridSchulze, K=7103137549en_HK
dc.identifier.scopusauthoridMcDonald, C=8749594800en_HK
dc.identifier.scopusauthoridChapple, B=6603274265en_HK
dc.identifier.scopusauthoridRabeHesketh, S=7003779088en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK

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