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Article: Association between BDNF val66 met genotype and episodic memory

TitleAssociation between BDNF val66 met genotype and episodic memory
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2005
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 2005, v. 134 B n. 1, p. 73-75 How to Cite?
AbstractThe val66 met polymorphism of brain derived neurotrophic factor (BDNF) has been associated with variability in episodic memory [Egan et al., 2003]. In an attempt to replicate this finding, we genotyped 206 individuals (92 affected with schizophrenia or a related disorder and 114 unaffected relatives) from the Maudsley Family Study for the BDNF val66 met polymorphism. We analyzed the effect of this polymorphism on episodic memory using the Wechsler Memory Scale, revised version (WMS-R) by regression analysis between the WMS delayed score of logical memory and genotype (corrected for age, sex, and IQ). We found the met66 allele conferred a lower score on the WMS delayed measure (R2 = 0.014 P = 0.09), which was not significant. When cases and unaffected relatives were analyzed separately, met66 was associated with a lower score on the WMS delayed measure in the relatives only (R2 = 0.077 P = 0.01), which is consistent with previous findings. © 2005 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/141868
ISSN
2015 Impact Factor: 3.391
2015 SCImago Journal Rankings: 1.771
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDempster, Een_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorMcDonald, Cen_HK
dc.contributor.authorBramon, Een_HK
dc.contributor.authorWalshe, Men_HK
dc.contributor.authorFilbey, Fen_HK
dc.contributor.authorWickham, Hen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorCollier, DAen_HK
dc.date.accessioned2011-09-27T03:03:37Z-
dc.date.available2011-09-27T03:03:37Z-
dc.date.issued2005en_HK
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 2005, v. 134 B n. 1, p. 73-75en_HK
dc.identifier.issn1552-4841en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141868-
dc.description.abstractThe val66 met polymorphism of brain derived neurotrophic factor (BDNF) has been associated with variability in episodic memory [Egan et al., 2003]. In an attempt to replicate this finding, we genotyped 206 individuals (92 affected with schizophrenia or a related disorder and 114 unaffected relatives) from the Maudsley Family Study for the BDNF val66 met polymorphism. We analyzed the effect of this polymorphism on episodic memory using the Wechsler Memory Scale, revised version (WMS-R) by regression analysis between the WMS delayed score of logical memory and genotype (corrected for age, sex, and IQ). We found the met66 allele conferred a lower score on the WMS delayed measure (R2 = 0.014 P = 0.09), which was not significant. When cases and unaffected relatives were analyzed separately, met66 was associated with a lower score on the WMS delayed measure in the relatives only (R2 = 0.077 P = 0.01), which is consistent with previous findings. © 2005 Wiley-Liss, Inc.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/en_HK
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.titleAssociation between BDNF val66 met genotype and episodic memoryen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T: timothea@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ajmg.b.30150en_HK
dc.identifier.pmid15719396en_HK
dc.identifier.scopuseid_2-s2.0-15744378045en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-15744378045&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume134 Ben_HK
dc.identifier.issue1en_HK
dc.identifier.spage73en_HK
dc.identifier.epage75en_HK
dc.identifier.isiWOS:000227927100015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridDempster, E=8414816000en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridMcDonald, C=8749594800en_HK
dc.identifier.scopusauthoridBramon, E=8089378900en_HK
dc.identifier.scopusauthoridWalshe, M=8855469300en_HK
dc.identifier.scopusauthoridFilbey, F=13606061900en_HK
dc.identifier.scopusauthoridWickham, H=6701762103en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridCollier, DA=26642980600en_HK

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