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Article: Dermatoglyphics and schizophrenia: A meta-analysis and investigation of the impact of obstetric complications upon a-b ridge count

TitleDermatoglyphics and schizophrenia: A meta-analysis and investigation of the impact of obstetric complications upon a-b ridge count
Authors
Keywordsa-b Ridge count
Dermatoglyphics
Family study
Meta-analysis
Obstetric complications
Schizophrenia
Issue Date2005
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2005, v. 75 n. 2-3, p. 399-404 How to Cite?
AbstractBackground: Patients with schizophrenia show deviances in their dermatoglyphics, in particular reductions in palmar a-b ridge counts (ABRCs), which are evidence of an early developmental deviance. However, the severity or the origin of these ABRC changes has not been established. Method: (i) We examined the published literature on the ABRC in patients with schizophrenia against controls with a random effects meta-analysis. (ii) We used linear regression to study the ABRC in our sample of families including 125 patients with schizophrenia, 107 of their unaffected relatives and 98 controls. (iii) The effect of obstetric complications on the patient's ABRC was examined using the Lewis Murray scale. Results: The pooled standardised effect size of ABRC differences between patients and controls obtained by our meta-analysis was 0.39 (95% CI: 0.05-0.73; p=0.03). In our sample, there were no significant differences in ABRCs between those with schizophrenia, their relatives and controls. Only those patients with obstetric complications had significantly reduced ABRC compared to controls (p=0.01). Conclusions: We confirmed the presence of significant yet mild ABRC reductions in schizophrenia. These represent a subtle deviance from the norm and could be present in certain subsets of patients, possibly those who suffered early developmental insults. © 2004 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/141866
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBramon, Een_HK
dc.contributor.authorWalshe, Men_HK
dc.contributor.authorMcDonald, Cen_HK
dc.contributor.authorMartín, Ben_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorWickham, Hen_HK
dc.contributor.authorVan Os, Jen_HK
dc.contributor.authorFearon, Pen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorFañanás, Len_HK
dc.contributor.authorMurray, RMen_HK
dc.date.accessioned2011-09-27T03:03:34Z-
dc.date.available2011-09-27T03:03:34Z-
dc.date.issued2005en_HK
dc.identifier.citationSchizophrenia Research, 2005, v. 75 n. 2-3, p. 399-404en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141866-
dc.description.abstractBackground: Patients with schizophrenia show deviances in their dermatoglyphics, in particular reductions in palmar a-b ridge counts (ABRCs), which are evidence of an early developmental deviance. However, the severity or the origin of these ABRC changes has not been established. Method: (i) We examined the published literature on the ABRC in patients with schizophrenia against controls with a random effects meta-analysis. (ii) We used linear regression to study the ABRC in our sample of families including 125 patients with schizophrenia, 107 of their unaffected relatives and 98 controls. (iii) The effect of obstetric complications on the patient's ABRC was examined using the Lewis Murray scale. Results: The pooled standardised effect size of ABRC differences between patients and controls obtained by our meta-analysis was 0.39 (95% CI: 0.05-0.73; p=0.03). In our sample, there were no significant differences in ABRCs between those with schizophrenia, their relatives and controls. Only those patients with obstetric complications had significantly reduced ABRC compared to controls (p=0.01). Conclusions: We confirmed the presence of significant yet mild ABRC reductions in schizophrenia. These represent a subtle deviance from the norm and could be present in certain subsets of patients, possibly those who suffered early developmental insults. © 2004 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.subjecta-b Ridge counten_HK
dc.subjectDermatoglyphicsen_HK
dc.subjectFamily studyen_HK
dc.subjectMeta-analysisen_HK
dc.subjectObstetric complicationsen_HK
dc.subjectSchizophreniaen_HK
dc.titleDermatoglyphics and schizophrenia: A meta-analysis and investigation of the impact of obstetric complications upon a-b ridge counten_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T: timothea@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.schres.2004.08.022en_HK
dc.identifier.pmid15885530-
dc.identifier.scopuseid_2-s2.0-21044444281en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-21044444281&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume75en_HK
dc.identifier.issue2-3en_HK
dc.identifier.spage399en_HK
dc.identifier.epage404en_HK
dc.identifier.isiWOS:000229665100025-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridBramon, E=8089378900en_HK
dc.identifier.scopusauthoridWalshe, M=8855469300en_HK
dc.identifier.scopusauthoridMcDonald, C=8749594800en_HK
dc.identifier.scopusauthoridMartín, B=7402931566en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridWickham, H=6701762103en_HK
dc.identifier.scopusauthoridVan Os, J=7102358027en_HK
dc.identifier.scopusauthoridFearon, P=7003273960en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridFañanás, L=7003809352en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.citeulike215425-

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