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Article: The Maudsley Family study: Premorbid and current general intellectual function levels in familial bipolar I disorder and schizophrenia

TitleThe Maudsley Family study: Premorbid and current general intellectual function levels in familial bipolar I disorder and schizophrenia
Authors
KeywordsReferences (60) View In Table Layout
Issue Date2006
PublisherPsychology Press. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/13803395.asp
Citation
Journal Of Clinical And Experimental Neuropsychology, 2006, v. 28 n. 2, p. 243-259 How to Cite?
AbstractThe distinction of psychosis into schizophrenia and bipolar disorder has been increasingly challenged with some evidence suggesting that the two conditions may have common etiologic and pathogenic mechanisms. We compared the premorbid and current intellectual function of bipolar patients from multiply affected families, and those of their first-degree relatives, with those of a similar series of schizophrenic subjects, as well as their relatives, and normal controls. Only schizophrenic subjects showed lower premorbid IQ, suggesting that they, but not the bipolar patients or either relative group, had suffered neurodevelopmental impairment. However, both groups of patients had comparably poor current general intellectual levels, implying that some common pathogenic process operates once illness has begun. The two groups of relatives showed distinct differences in intellectual function but we cannot exclude the possibility that these were a function of our sampling methods. Copyright © Taylor & Francis Group, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/141862
ISSN
2015 Impact Factor: 1.693
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorQuraishi, Sen_HK
dc.contributor.authorMcDonald, Cen_HK
dc.contributor.authorMurray, RMen_HK
dc.date.accessioned2011-09-27T03:03:28Z-
dc.date.available2011-09-27T03:03:28Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Clinical And Experimental Neuropsychology, 2006, v. 28 n. 2, p. 243-259en_HK
dc.identifier.issn1380-3395en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141862-
dc.description.abstractThe distinction of psychosis into schizophrenia and bipolar disorder has been increasingly challenged with some evidence suggesting that the two conditions may have common etiologic and pathogenic mechanisms. We compared the premorbid and current intellectual function of bipolar patients from multiply affected families, and those of their first-degree relatives, with those of a similar series of schizophrenic subjects, as well as their relatives, and normal controls. Only schizophrenic subjects showed lower premorbid IQ, suggesting that they, but not the bipolar patients or either relative group, had suffered neurodevelopmental impairment. However, both groups of patients had comparably poor current general intellectual levels, implying that some common pathogenic process operates once illness has begun. The two groups of relatives showed distinct differences in intellectual function but we cannot exclude the possibility that these were a function of our sampling methods. Copyright © Taylor & Francis Group, LLC.en_HK
dc.languageengen_US
dc.publisherPsychology Press. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/13803395.aspen_HK
dc.relation.ispartofJournal of Clinical and Experimental Neuropsychologyen_HK
dc.subjectReferences (60) View In Table Layouten_US
dc.titleThe Maudsley Family study: Premorbid and current general intellectual function levels in familial bipolar I disorder and schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1080/13803390500360513en_HK
dc.identifier.pmid16484096-
dc.identifier.scopuseid_2-s2.0-32844474158en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-32844474158&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue2en_HK
dc.identifier.spage243en_HK
dc.identifier.epage259en_HK
dc.identifier.isiWOS:000235534000006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridQuraishi, S=6603840181en_HK
dc.identifier.scopusauthoridMcDonald, C=8749594800en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK

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