File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Neurological abnormalities in schizophrenic twins

TitleNeurological abnormalities in schizophrenic twins
Authors
KeywordsConcordant
Discordant
Genetic
Neurological abnormalities
Schizophrenia
Twins
Issue Date2006
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiat
Citation
Biological Psychiatry, 2006, v. 59 n. 4, p. 341-348 How to Cite?
AbstractBackground: Neurological abnormalities (NAs) are well recognized in schizophrenia, though their genetic and environmental determinants, and pathophysiological significance, are poorly understood. Methods: Sixty-three twin pairs, varying in their zygosity and concordance for schizophrenia, and 73 unaffected control twin pairs were examined for total, primary and integrative NAs using the Neurological Evaluation Scale. Results: NAs were increased in probands with schizophrenia compared to nonschizophrenic co-twins and to healthy control twins but there were no significant differences between patients from the concordant and discordant pairs. NAs in the nonpsychotic co-twins from discordant pairs were increased compared to control twins. There were no significant differences in NAs between the nonschizophrenic co-twins from monozygotic (MZ) and dizygotic (DZ) discordant pairs, but the within pair correlations were greater in the MZ compared to DZ pairs. NAs were modified in all groups by pre-morbid schizotypal traits, and in patients by anti-psychotic medication. Conclusions: NAs in schizophrenia are determined in part by genetic risk for the illness but the presence of premorbid schizotypal traits, and anti-psychotic medication confer additional risk for NAs. © 2006 Society of Biological Psychiatry.
Persistent Identifierhttp://hdl.handle.net/10722/141861
ISSN
2015 Impact Factor: 11.212
2015 SCImago Journal Rankings: 5.823
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPicchioni, MMen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorLandau, Sen_HK
dc.contributor.authorDavies, Nen_HK
dc.contributor.authorRibchester, Ten_HK
dc.contributor.authorMurray, RMen_HK
dc.date.accessioned2011-09-27T03:03:27Z-
dc.date.available2011-09-27T03:03:27Z-
dc.date.issued2006en_HK
dc.identifier.citationBiological Psychiatry, 2006, v. 59 n. 4, p. 341-348en_HK
dc.identifier.issn0006-3223en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141861-
dc.description.abstractBackground: Neurological abnormalities (NAs) are well recognized in schizophrenia, though their genetic and environmental determinants, and pathophysiological significance, are poorly understood. Methods: Sixty-three twin pairs, varying in their zygosity and concordance for schizophrenia, and 73 unaffected control twin pairs were examined for total, primary and integrative NAs using the Neurological Evaluation Scale. Results: NAs were increased in probands with schizophrenia compared to nonschizophrenic co-twins and to healthy control twins but there were no significant differences between patients from the concordant and discordant pairs. NAs in the nonpsychotic co-twins from discordant pairs were increased compared to control twins. There were no significant differences in NAs between the nonschizophrenic co-twins from monozygotic (MZ) and dizygotic (DZ) discordant pairs, but the within pair correlations were greater in the MZ compared to DZ pairs. NAs were modified in all groups by pre-morbid schizotypal traits, and in patients by anti-psychotic medication. Conclusions: NAs in schizophrenia are determined in part by genetic risk for the illness but the presence of premorbid schizotypal traits, and anti-psychotic medication confer additional risk for NAs. © 2006 Society of Biological Psychiatry.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiaten_HK
dc.relation.ispartofBiological Psychiatryen_HK
dc.subjectConcordanten_HK
dc.subjectDiscordanten_HK
dc.subjectGeneticen_HK
dc.subjectNeurological abnormalitiesen_HK
dc.subjectSchizophreniaen_HK
dc.subjectTwinsen_HK
dc.titleNeurological abnormalities in schizophrenic twinsen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.biopsych.2005.07.007en_HK
dc.identifier.pmid16169527-
dc.identifier.scopuseid_2-s2.0-32544444840en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-32544444840&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume59en_HK
dc.identifier.issue4en_HK
dc.identifier.spage341en_HK
dc.identifier.epage348en_HK
dc.identifier.isiWOS:000235670800007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPicchioni, MM=6507443795en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridLandau, S=7101776972en_HK
dc.identifier.scopusauthoridDavies, N=7202610654en_HK
dc.identifier.scopusauthoridRibchester, T=6506172219en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats