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Article: Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene

TitleEpisodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene
Authors
Issue Date2006
PublisherAmerican Psychiatric Publishing, Inc. The Journal's web site is located at http://ajp.psychiatryonline.org
Citation
American Journal Of Psychiatry, 2006, v. 163 n. 10, p. 1832-1834 How to Cite?
AbstractObjective: There is evidence of linkage between chromosome 15q14 and the P50 auditory evoked response, a heritable neuropsychological marker associated with increased risk of schizophrenia. Chromosome 15q14 harbors the alpha-7 nicotinic receptor subunit gene (CHRNA7) and a hybrid gene of unknown function (CHRFAM7A). CHRNA7 is involved in memory formation, a core dysfunction in schizophrenia. The authors set out to determine if this locus is associated with memory dysfunction in schizophrenia. Method: A 2bp deletion in exon 6 of CHRFAM7A, which disrupts the hybrid gene and has previously been associated with P50 deficit, was genotyped in 251 individuals from the Maudsley Family Study of schizophrenia. Episodic memory function was assessed using the Wechsler Memory Scale. Results: Significant associations were identified with delayed recall and percentage retained, with the presence of the deletion predicting worse performance. Conclusions: These observations indicate that episodic memory function is a schizophrenia endophenotype and implicate the CHRFAM7A/CHRNA7 locus in modulating its function.
Persistent Identifierhttp://hdl.handle.net/10722/141857
ISSN
2015 Impact Factor: 13.505
2015 SCImago Journal Rankings: 5.218
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDempster, ELen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorMcDonald, Cen_HK
dc.contributor.authorBramon, Een_HK
dc.contributor.authorWalshe, Men_HK
dc.contributor.authorWickham, Hen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorCollier, DAen_HK
dc.date.accessioned2011-09-27T03:03:23Z-
dc.date.available2011-09-27T03:03:23Z-
dc.date.issued2006en_HK
dc.identifier.citationAmerican Journal Of Psychiatry, 2006, v. 163 n. 10, p. 1832-1834en_HK
dc.identifier.issn0002-953Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/141857-
dc.description.abstractObjective: There is evidence of linkage between chromosome 15q14 and the P50 auditory evoked response, a heritable neuropsychological marker associated with increased risk of schizophrenia. Chromosome 15q14 harbors the alpha-7 nicotinic receptor subunit gene (CHRNA7) and a hybrid gene of unknown function (CHRFAM7A). CHRNA7 is involved in memory formation, a core dysfunction in schizophrenia. The authors set out to determine if this locus is associated with memory dysfunction in schizophrenia. Method: A 2bp deletion in exon 6 of CHRFAM7A, which disrupts the hybrid gene and has previously been associated with P50 deficit, was genotyped in 251 individuals from the Maudsley Family Study of schizophrenia. Episodic memory function was assessed using the Wechsler Memory Scale. Results: Significant associations were identified with delayed recall and percentage retained, with the presence of the deletion predicting worse performance. Conclusions: These observations indicate that episodic memory function is a schizophrenia endophenotype and implicate the CHRFAM7A/CHRNA7 locus in modulating its function.en_HK
dc.languageengen_US
dc.publisherAmerican Psychiatric Publishing, Inc. The Journal's web site is located at http://ajp.psychiatryonline.orgen_HK
dc.relation.ispartofAmerican Journal of Psychiatryen_HK
dc.titleEpisodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit geneen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T: timothea@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1176/appi.ajp.163.10.1832en_HK
dc.identifier.pmid17012698-
dc.identifier.scopuseid_2-s2.0-33749458682en_HK
dc.identifier.hkuros133435-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33749458682&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume163en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1832en_HK
dc.identifier.epage1834en_HK
dc.identifier.isiWOS:000240906800031-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridDempster, EL=8414816000en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridMcDonald, C=8749594800en_HK
dc.identifier.scopusauthoridBramon, E=8089378900en_HK
dc.identifier.scopusauthoridWalshe, M=8855469300en_HK
dc.identifier.scopusauthoridWickham, H=6701762103en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridCollier, DA=26642980600en_HK

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