File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Magnetic resonance imaging of the thalamus and adhesio interthalamica in twins with schizophrenia

TitleMagnetic resonance imaging of the thalamus and adhesio interthalamica in twins with schizophrenia
Authors
KeywordsReferences (71) View In Table Layout
Issue Date2007
PublisherAmerican Medical Association. The Journal's web site is located at http://www.archgenpsychiatry.com
Citation
Archives Of General Psychiatry, 2007, v. 64 n. 4, p. 401-409 How to Cite?
AbstractContext: Abnormalities of the thalamus are thought to be central to the pathophysiology of schizophrenia. These abnormalities include altered structure and shape of the thalamus itself and possibly changes to the adhesio interthalamica (or massa intermedia), the gray matter bridge connecting the 2 thalamic lobes. However, it is not clear to what extent these abnormalities are determined by the genetic liability for schizophrenia. Objective: To investigate thalamic volume and the presence of the adhesio interthalamica in monozygotic (MZ) twins concordant or discordant for schizophrenia. Design: Study of MZ twins. Setting: Patients were drawn from inpatient and outpatient clinics. Twin controls were recruited from a volunteer twin register and through media advertisements. Participants: A total of 123 twins participated: 19 MZ twin pairs concordant for schizophrenia, 15 MZ schizophrenic twins and 16 MZ nonschizophrenic twins drawn from 17 pairs discordant for schizophrenia, and 27 MZ twin pairs without schizophrenia. Groups were matched for age, sex, handedness, level of education, parental socioeconomic status, and ethnicity. Main Outcome Measures: The volume of the thalamus (including right and left hemispheres) was measured (in cubic centimeters) and the presence of the adhesio interthalamica was ascertained from structural magnetic resonance images. Results: Concordant twin pairs displayed significantly reduced thalamic volume compared with control twins, even when covarying for effects of whole-brain volume, age, and sex. There was a significant linear decrease in thalamic volume (controlgreater thandiscordant nonschizophrenic greater thandiscordant schizophrenicgreater thanconcordant). In all groups, right thalamus was larger than left thalamus. There was no difference across groups in the frequency of the adhesio interthalamica. Conclusions: Volumetric thalamic abnormalities in schizophrenia occur in twin pairs concordant for schizophrenia. These abnormalities may mark the substantial genetic contribution to the illness seen in concordant twin pairs, whereas the adhesio interthalamica is unlikely to be affected in schizophrenia. ©2007 American Medical Association. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/141856
ISSN
2014 Impact Factor: 14.48
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorEttinger, Uen_HK
dc.contributor.authorPicchioni, Men_HK
dc.contributor.authorLandau, Sen_HK
dc.contributor.authorMatsumoto, Ken_HK
dc.contributor.authorVan Haren, NEen_HK
dc.contributor.authorMarshall, Nen_HK
dc.contributor.authorHall, MHen_HK
dc.contributor.authorSchulze, Ken_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorDavies, Nen_HK
dc.contributor.authorRibchester, Ten_HK
dc.contributor.authorMcGuire, PKen_HK
dc.contributor.authorMurray, RMen_HK
dc.date.accessioned2011-09-27T03:03:21Z-
dc.date.available2011-09-27T03:03:21Z-
dc.date.issued2007en_HK
dc.identifier.citationArchives Of General Psychiatry, 2007, v. 64 n. 4, p. 401-409en_HK
dc.identifier.issn0003-990Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/141856-
dc.description.abstractContext: Abnormalities of the thalamus are thought to be central to the pathophysiology of schizophrenia. These abnormalities include altered structure and shape of the thalamus itself and possibly changes to the adhesio interthalamica (or massa intermedia), the gray matter bridge connecting the 2 thalamic lobes. However, it is not clear to what extent these abnormalities are determined by the genetic liability for schizophrenia. Objective: To investigate thalamic volume and the presence of the adhesio interthalamica in monozygotic (MZ) twins concordant or discordant for schizophrenia. Design: Study of MZ twins. Setting: Patients were drawn from inpatient and outpatient clinics. Twin controls were recruited from a volunteer twin register and through media advertisements. Participants: A total of 123 twins participated: 19 MZ twin pairs concordant for schizophrenia, 15 MZ schizophrenic twins and 16 MZ nonschizophrenic twins drawn from 17 pairs discordant for schizophrenia, and 27 MZ twin pairs without schizophrenia. Groups were matched for age, sex, handedness, level of education, parental socioeconomic status, and ethnicity. Main Outcome Measures: The volume of the thalamus (including right and left hemispheres) was measured (in cubic centimeters) and the presence of the adhesio interthalamica was ascertained from structural magnetic resonance images. Results: Concordant twin pairs displayed significantly reduced thalamic volume compared with control twins, even when covarying for effects of whole-brain volume, age, and sex. There was a significant linear decrease in thalamic volume (controlgreater thandiscordant nonschizophrenic greater thandiscordant schizophrenicgreater thanconcordant). In all groups, right thalamus was larger than left thalamus. There was no difference across groups in the frequency of the adhesio interthalamica. Conclusions: Volumetric thalamic abnormalities in schizophrenia occur in twin pairs concordant for schizophrenia. These abnormalities may mark the substantial genetic contribution to the illness seen in concordant twin pairs, whereas the adhesio interthalamica is unlikely to be affected in schizophrenia. ©2007 American Medical Association. All rights reserved.en_HK
dc.languageengen_US
dc.publisherAmerican Medical Association. The Journal's web site is located at http://www.archgenpsychiatry.comen_HK
dc.relation.ispartofArchives of General Psychiatryen_HK
dc.subjectReferences (71) View In Table Layouten_US
dc.titleMagnetic resonance imaging of the thalamus and adhesio interthalamica in twins with schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1001/archpsyc.64.4.401en_HK
dc.identifier.pmid17404117-
dc.identifier.scopuseid_2-s2.0-34147105091en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34147105091&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume64en_HK
dc.identifier.issue4en_HK
dc.identifier.spage401en_HK
dc.identifier.epage409en_HK
dc.identifier.eissn1538-3636-
dc.identifier.isiWOS:000245374800002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridEttinger, U=6602766172en_HK
dc.identifier.scopusauthoridPicchioni, M=6507443795en_HK
dc.identifier.scopusauthoridLandau, S=7101776972en_HK
dc.identifier.scopusauthoridMatsumoto, K=7601610506en_HK
dc.identifier.scopusauthoridVan Haren, NE=6603501057en_HK
dc.identifier.scopusauthoridMarshall, N=7102431159en_HK
dc.identifier.scopusauthoridHall, MH=14013171900en_HK
dc.identifier.scopusauthoridSchulze, K=7103137549en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridDavies, N=7202610654en_HK
dc.identifier.scopusauthoridRibchester, T=6506172219en_HK
dc.identifier.scopusauthoridMcGuire, PK=7101880438en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats