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Article: Reaction time and sustained attention in schizophrenia and its genetic predisposition

TitleReaction time and sustained attention in schizophrenia and its genetic predisposition
Authors
Keywords1/f noise
Continuous performance test
Endophenotype
Intra-individual variability
Schizophrenia
Issue Date2007
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2007, v. 95 n. 1-3, p. 76-85 How to Cite?
AbstractSustained attention is affected by schizophrenia. The simplest form of Continuous Performance Test (CPT-X) is a purer test of vigilance than more demanding variants but widely thought too insensitive to detect abnormalities in those with genetic predisposition to schizophrenia. We used a 7-minute CPT to compare 61 patients diagnosed with schizophrenia, 45 of their never-psychotic relatives, and 47 control subjects. We found a significant impairment in stimulus discrimination in both patients (p = 0.001) and their relatives (p = 0.006). There was no difference in stimulus discrimination between relatives of patients with impaired and unimpaired stimulus discrimination. Relatives of patients with unimpaired stimulus discrimination were still inferior to controls (p = 0.02). Reactions slowed in all groups equally as the test progressed. Patients showed increased mean reaction time (p < 0.0001) and interquartile range (p = 0.003). Relatives showed slower reaction times (p = 0.01) but normal interquartile range. Groups did not differ in respect of individuals' fastest reaction times. We conclude that genetic predisposition to schizophrenia reduces performance even during a task placing minimal cognitive load on working memory and perceptual processing, suggesting impaired vigilance. Increased reaction time in the disease and its predisposition appear to be due to changes in response distribution rather than by a limitation of maximum speed. Our results raise the possibility of separating the cognitive components of vigilance, working memory and perceptual processing tapped by more demanding variants of the CPT, and draw attention to the need for consideration of dynamic neurocognitive processes in schizophrenia. © 2007 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/141854
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBirkett, Pen_HK
dc.contributor.authorSigmundsson, Ten_HK
dc.contributor.authorSharma, Ten_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorGriffiths, TDen_HK
dc.contributor.authorReveley, Aen_HK
dc.contributor.authorMurray, Ren_HK
dc.date.accessioned2011-09-27T03:03:19Z-
dc.date.available2011-09-27T03:03:19Z-
dc.date.issued2007en_HK
dc.identifier.citationSchizophrenia Research, 2007, v. 95 n. 1-3, p. 76-85en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141854-
dc.description.abstractSustained attention is affected by schizophrenia. The simplest form of Continuous Performance Test (CPT-X) is a purer test of vigilance than more demanding variants but widely thought too insensitive to detect abnormalities in those with genetic predisposition to schizophrenia. We used a 7-minute CPT to compare 61 patients diagnosed with schizophrenia, 45 of their never-psychotic relatives, and 47 control subjects. We found a significant impairment in stimulus discrimination in both patients (p = 0.001) and their relatives (p = 0.006). There was no difference in stimulus discrimination between relatives of patients with impaired and unimpaired stimulus discrimination. Relatives of patients with unimpaired stimulus discrimination were still inferior to controls (p = 0.02). Reactions slowed in all groups equally as the test progressed. Patients showed increased mean reaction time (p < 0.0001) and interquartile range (p = 0.003). Relatives showed slower reaction times (p = 0.01) but normal interquartile range. Groups did not differ in respect of individuals' fastest reaction times. We conclude that genetic predisposition to schizophrenia reduces performance even during a task placing minimal cognitive load on working memory and perceptual processing, suggesting impaired vigilance. Increased reaction time in the disease and its predisposition appear to be due to changes in response distribution rather than by a limitation of maximum speed. Our results raise the possibility of separating the cognitive components of vigilance, working memory and perceptual processing tapped by more demanding variants of the CPT, and draw attention to the need for consideration of dynamic neurocognitive processes in schizophrenia. © 2007 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.subject1/f noiseen_HK
dc.subjectContinuous performance testen_HK
dc.subjectEndophenotypeen_HK
dc.subjectIntra-individual variabilityen_HK
dc.subjectSchizophreniaen_HK
dc.titleReaction time and sustained attention in schizophrenia and its genetic predispositionen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.schres.2007.05.030en_HK
dc.identifier.pmid17630256-
dc.identifier.scopuseid_2-s2.0-34548208313en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34548208313&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume95en_HK
dc.identifier.issue1-3en_HK
dc.identifier.spage76en_HK
dc.identifier.epage85en_HK
dc.identifier.isiWOS:000249836900011-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridBirkett, P=16168874500en_HK
dc.identifier.scopusauthoridSigmundsson, T=6602171613en_HK
dc.identifier.scopusauthoridSharma, T=7202571892en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridGriffiths, TD=7102183421en_HK
dc.identifier.scopusauthoridReveley, A=6701641246en_HK
dc.identifier.scopusauthoridMurray, R=35406239400en_HK

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