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Article: Selective attention deficits reflect increased genetic vulnerability to schizophrenia

TitleSelective attention deficits reflect increased genetic vulnerability to schizophrenia
Authors
KeywordsAttention
Biological markers
Familial
Obligate carriers
Schizophrenia
Issue Date2008
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2008, v. 101 n. 1-3, p. 169-175 How to Cite?
Abstract
Background: Impairment in attention is prominent in schizophrenia and may be a valuable genetic indicator for vulnerability to this disease. Aims: We set out to characterize the attention deficits that may be associated with genetic liability to schizophrenia. Methods: We compared attention performance in 55 people with schizophrenia, 95 of their first-degree relatives, and 61 unrelated controls. We also segregated presumed obligate carriers of genetic risk (POCs, N = 12) and compared their performance with that of controls. Results: Although the relatives of people with schizophrenia did not significantly differ from the normal controls on the tasks of attention, their scores were significantly ordered such that patients > relatives > normal controls during tasks of sustained and selective attention as measured by the Jonckheere-Terpstra Test (p < .05). Additionally, POCs were significantly worse than normal controls during selective attention tasks such as the Stroop (p = .03) and Letter Cancellation Task (p = .04). Conclusions: Heterogeneity in the first-degree relatives may have diluted the attention deficits present in those who are at genetic risk for schizophrenia. On the other hand, our findings in the more homogeneous group of POCs suggest that selective attention may be an indicator of genetic liability for schizophrenia. © 2008 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/141849
ISSN
2013 Impact Factor: 4.426
2013 SCImago Journal Rankings: 3.163
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFilbey, FMen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorMorris, RGen_HK
dc.contributor.authorMcDonald, Cen_HK
dc.contributor.authorBramon, Een_HK
dc.contributor.authorWalshe, Men_HK
dc.contributor.authorMurray, RMen_HK
dc.date.accessioned2011-09-27T03:03:13Z-
dc.date.available2011-09-27T03:03:13Z-
dc.date.issued2008en_HK
dc.identifier.citationSchizophrenia Research, 2008, v. 101 n. 1-3, p. 169-175en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141849-
dc.description.abstractBackground: Impairment in attention is prominent in schizophrenia and may be a valuable genetic indicator for vulnerability to this disease. Aims: We set out to characterize the attention deficits that may be associated with genetic liability to schizophrenia. Methods: We compared attention performance in 55 people with schizophrenia, 95 of their first-degree relatives, and 61 unrelated controls. We also segregated presumed obligate carriers of genetic risk (POCs, N = 12) and compared their performance with that of controls. Results: Although the relatives of people with schizophrenia did not significantly differ from the normal controls on the tasks of attention, their scores were significantly ordered such that patients > relatives > normal controls during tasks of sustained and selective attention as measured by the Jonckheere-Terpstra Test (p < .05). Additionally, POCs were significantly worse than normal controls during selective attention tasks such as the Stroop (p = .03) and Letter Cancellation Task (p = .04). Conclusions: Heterogeneity in the first-degree relatives may have diluted the attention deficits present in those who are at genetic risk for schizophrenia. On the other hand, our findings in the more homogeneous group of POCs suggest that selective attention may be an indicator of genetic liability for schizophrenia. © 2008 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.subjectAttentionen_HK
dc.subjectBiological markersen_HK
dc.subjectFamilialen_HK
dc.subjectObligate carriersen_HK
dc.subjectSchizophreniaen_HK
dc.titleSelective attention deficits reflect increased genetic vulnerability to schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.schres.2008.01.019en_HK
dc.identifier.pmid18291626en_HK
dc.identifier.scopuseid_2-s2.0-42749097977en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-42749097977&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume101en_HK
dc.identifier.issue1-3en_HK
dc.identifier.spage169en_HK
dc.identifier.epage175en_HK
dc.identifier.isiWOS:000256212200019-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridFilbey, FM=13606061900en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridMorris, RG=7404060505en_HK
dc.identifier.scopusauthoridMcDonald, C=8749594800en_HK
dc.identifier.scopusauthoridBramon, E=8089378900en_HK
dc.identifier.scopusauthoridWalshe, M=8855469300en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK

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