Article: Selective attention deficits reflect increased genetic vulnerability to schizophrenia

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TitleSelective attention deficits reflect increased genetic vulnerability to schizophrenia
AuthorsFilbey, FM1
Toulopoulou, T1
Morris, RG1
McDonald, C1
Bramon, E1
Walshe, M1
Murray, RM1
KeywordsAttention
Biological markers
Familial
Obligate carriers
Schizophrenia
Issue Date2008
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
CitationSchizophrenia Research, 2008, v. 101 n. 1-3, p. 169-175 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.schres.2008.01.019
AbstractBackground: Impairment in attention is prominent in schizophrenia and may be a valuable genetic indicator for vulnerability to this disease. Aims: We set out to characterize the attention deficits that may be associated with genetic liability to schizophrenia. Methods: We compared attention performance in 55 people with schizophrenia, 95 of their first-degree relatives, and 61 unrelated controls. We also segregated presumed obligate carriers of genetic risk (POCs, N = 12) and compared their performance with that of controls. Results: Although the relatives of people with schizophrenia did not significantly differ from the normal controls on the tasks of attention, their scores were significantly ordered such that patients > relatives > normal controls during tasks of sustained and selective attention as measured by the Jonckheere-Terpstra Test (p < .05). Additionally, POCs were significantly worse than normal controls during selective attention tasks such as the Stroop (p = .03) and Letter Cancellation Task (p = .04). Conclusions: Heterogeneity in the first-degree relatives may have diluted the attention deficits present in those who are at genetic risk for schizophrenia. On the other hand, our findings in the more homogeneous group of POCs suggest that selective attention may be an indicator of genetic liability for schizophrenia. © 2008 Elsevier B.V. All rights reserved.
ISSN0920-9964
2011 Impact Factor: 4.748
2011 SCImago Journal Rankings: 0.249
DOIhttp://dx.doi.org/10.1016/j.schres.2008.01.019
ISI Accession Number IDWOS:000256212200019
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorFilbey, FM
dc.contributor.authorToulopoulou, T
dc.contributor.authorMorris, RG
dc.contributor.authorMcDonald, C
dc.contributor.authorBramon, E
dc.contributor.authorWalshe, M
dc.contributor.authorMurray, RM
dc.date.accessioned2011-09-27T03:03:13Z
dc.date.available2011-09-27T03:03:13Z
dc.date.issued2008
dc.description.abstractBackground: Impairment in attention is prominent in schizophrenia and may be a valuable genetic indicator for vulnerability to this disease. Aims: We set out to characterize the attention deficits that may be associated with genetic liability to schizophrenia. Methods: We compared attention performance in 55 people with schizophrenia, 95 of their first-degree relatives, and 61 unrelated controls. We also segregated presumed obligate carriers of genetic risk (POCs, N = 12) and compared their performance with that of controls. Results: Although the relatives of people with schizophrenia did not significantly differ from the normal controls on the tasks of attention, their scores were significantly ordered such that patients > relatives > normal controls during tasks of sustained and selective attention as measured by the Jonckheere-Terpstra Test (p < .05). Additionally, POCs were significantly worse than normal controls during selective attention tasks such as the Stroop (p = .03) and Letter Cancellation Task (p = .04). Conclusions: Heterogeneity in the first-degree relatives may have diluted the attention deficits present in those who are at genetic risk for schizophrenia. On the other hand, our findings in the more homogeneous group of POCs suggest that selective attention may be an indicator of genetic liability for schizophrenia. © 2008 Elsevier B.V. All rights reserved.
dc.description.naturelink_to_subscribed_fulltext
dc.identifier.citationSchizophrenia Research, 2008, v. 101 n. 1-3, p. 169-175 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.schres.2008.01.019
dc.identifier.doihttp://dx.doi.org/10.1016/j.schres.2008.01.019
dc.identifier.epage175
dc.identifier.isiWOS:000256212200019
dc.identifier.issn0920-9964
2011 Impact Factor: 4.748
2011 SCImago Journal Rankings: 0.249
dc.identifier.issue1-3
dc.identifier.pmid18291626
dc.identifier.scopuseid_2-s2.0-42749097977
dc.identifier.spage169
dc.identifier.urihttp://hdl.handle.net/10722/141849
dc.identifier.volume101
dc.languageeng
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
dc.publisher.placeNetherlands
dc.relation.ispartofSchizophrenia Research
dc.relation.referencesReferences in Scopus
dc.subjectAttention
dc.subjectBiological markers
dc.subjectFamilial
dc.subjectObligate carriers
dc.subjectSchizophrenia
dc.titleSelective attention deficits reflect increased genetic vulnerability to schizophrenia
dc.typeArticle
Author Affiliations
  1. King's College London