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Article: Executive function and genetic predisposition to schizophrenia - The Maudsley family study

TitleExecutive function and genetic predisposition to schizophrenia - The Maudsley family study
Authors
KeywordsCognition
Endophenotype
Etiology
Genetics
Schizophrenia
Issue Date2008
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
Citation
American Journal Of Medical Genetics, Part B: Neuropsychiatric Genetics, 2008, v. 147 n. 3, p. 285-293 How to Cite?
AbstractExecutive cognitive impairment has been found in families affected by schizophrenia and is a putative endophenotype. We wished to explore its genetic basis further by studying the association between impairment and genetic loading for schizophrenia. We studied 30 schizophrenia patients with a family history of schizophrenia, 53 of their nonpsychotic first-degree relatives (familial), 32 patients with schizophrenia but no known family history of psychosis, 52 of their first-degree relatives (nonfamilial), and 47 normal controls. They were tested using the National Adult Reading Test (NART), Trails A and B, Verbal fluency tasks, and a computerized version of the Wisconsin Card Sorting Test (WCST). Familial, but not nonfamilial, relatives were impaired on NART, letter fluency, Trails B, and WCST total errors. They were inferior to nonfamilial relatives on letter fluency and Trails A. Both sets of relatives were impaired on Trails B controlling for Trails A, and on WCST categories achieved. There were no significant differences between schizophrenia patients with and without a family history. Our results suggest that executive deficits qualitatively similar to those seen in those with schizophrenia reflect familial susceptibility, even taking early IQ and education into consideration, consistent with a genetic mechanism. © 2007 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/141848
ISSN
2015 Impact Factor: 3.391
2015 SCImago Journal Rankings: 1.771
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBirkett, Pen_HK
dc.contributor.authorSigmundsson, Ten_HK
dc.contributor.authorSharma, Ten_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorGriffiths, TDen_HK
dc.contributor.authorReveley, Aen_HK
dc.contributor.authorMurray, Ren_HK
dc.date.accessioned2011-09-27T03:03:12Z-
dc.date.available2011-09-27T03:03:12Z-
dc.date.issued2008en_HK
dc.identifier.citationAmerican Journal Of Medical Genetics, Part B: Neuropsychiatric Genetics, 2008, v. 147 n. 3, p. 285-293en_HK
dc.identifier.issn1552-4841en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141848-
dc.description.abstractExecutive cognitive impairment has been found in families affected by schizophrenia and is a putative endophenotype. We wished to explore its genetic basis further by studying the association between impairment and genetic loading for schizophrenia. We studied 30 schizophrenia patients with a family history of schizophrenia, 53 of their nonpsychotic first-degree relatives (familial), 32 patients with schizophrenia but no known family history of psychosis, 52 of their first-degree relatives (nonfamilial), and 47 normal controls. They were tested using the National Adult Reading Test (NART), Trails A and B, Verbal fluency tasks, and a computerized version of the Wisconsin Card Sorting Test (WCST). Familial, but not nonfamilial, relatives were impaired on NART, letter fluency, Trails B, and WCST total errors. They were inferior to nonfamilial relatives on letter fluency and Trails A. Both sets of relatives were impaired on Trails B controlling for Trails A, and on WCST categories achieved. There were no significant differences between schizophrenia patients with and without a family history. Our results suggest that executive deficits qualitatively similar to those seen in those with schizophrenia reflect familial susceptibility, even taking early IQ and education into consideration, consistent with a genetic mechanism. © 2007 Wiley-Liss, Inc.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/en_HK
dc.relation.ispartofAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Geneticsen_HK
dc.subjectCognitionen_HK
dc.subjectEndophenotypeen_HK
dc.subjectEtiologyen_HK
dc.subjectGeneticsen_HK
dc.subjectSchizophreniaen_HK
dc.titleExecutive function and genetic predisposition to schizophrenia - The Maudsley family studyen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ajmg.b.30594en_HK
dc.identifier.pmid17853391-
dc.identifier.scopuseid_2-s2.0-42149134847en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-42149134847&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume147en_HK
dc.identifier.issue3en_HK
dc.identifier.spage285en_HK
dc.identifier.epage293en_HK
dc.identifier.eissn1552-485X-
dc.identifier.isiWOS:000254569400002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridBirkett, P=16168874500en_HK
dc.identifier.scopusauthoridSigmundsson, T=6602171613en_HK
dc.identifier.scopusauthoridSharma, T=7202571892en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridGriffiths, TD=7102183421en_HK
dc.identifier.scopusauthoridReveley, A=6701641246en_HK
dc.identifier.scopusauthoridMurray, R=35406239400en_HK

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