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Article: Differential methylation of the X-chromosome is a possible source of discordance for bipolar disorder female monozygotic twins

TitleDifferential methylation of the X-chromosome is a possible source of discordance for bipolar disorder female monozygotic twins
Authors
KeywordsBipolar disorder
Psychosis
Twins
X-chromosome inactivation
X-linkage
Issue Date2008
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
Citation
American Journal Of Medical Genetics, Part B: Neuropsychiatric Genetics, 2008, v. 147 n. 4, p. 459-462 How to Cite?
AbstractMonozygotic (MZ) twins may be subject to epigenetic modifications that could result in different patterns of gene expression. Several lines of evidence suggest that epigenetic factors may underlie mental disorders such as bipolar disorder (BD) and schizophrenia (SZ). One important epigenetic modification, of relevance to female MZ twins, is X-chromosome inactivation. Some MZ female twin pairs are discordant for monogenic X linked disorders because of differential X inactivation. We postulated that similar mechanisms may also occur in disorders with more complex inheritance including BD and SZ. Examination of X-chromosome inactivation patterns in DNA samples from blood and/or buccal swabs in a series of 63 female MZ twin pairs concordant or discordant for BD or SZ and healthy MZ controls suggests a potential contribution from X-linked loci to discordance within twin pairs for BD but is inconclusive for SZ. Discordant female bipolar twins showed greater differences in the methylation of the maternal and paternal X alleles than concordant twin pairs and suggest that differential skewing of X-chromosome inactivation may contribute to the discordance observed for bipolar disorder in female MZ twin pairs and the potential involvement of X-linked loci in the disorder. © 2007 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/141847
ISSN
2015 Impact Factor: 3.391
2015 SCImago Journal Rankings: 1.771
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRosa, Aen_HK
dc.contributor.authorPicchioni, MMen_HK
dc.contributor.authorKalidindi, Sen_HK
dc.contributor.authorLoat, CSen_HK
dc.contributor.authorKnight, Jen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorVonk, Ren_HK
dc.contributor.authorVan Der Schot, ACen_HK
dc.contributor.authorNolen, Wen_HK
dc.contributor.authorKahn, RSen_HK
dc.contributor.authorMcGuffin, Pen_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorCraig, IWen_HK
dc.date.accessioned2011-09-27T03:03:12Z-
dc.date.available2011-09-27T03:03:12Z-
dc.date.issued2008en_HK
dc.identifier.citationAmerican Journal Of Medical Genetics, Part B: Neuropsychiatric Genetics, 2008, v. 147 n. 4, p. 459-462en_HK
dc.identifier.issn1552-4841en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141847-
dc.description.abstractMonozygotic (MZ) twins may be subject to epigenetic modifications that could result in different patterns of gene expression. Several lines of evidence suggest that epigenetic factors may underlie mental disorders such as bipolar disorder (BD) and schizophrenia (SZ). One important epigenetic modification, of relevance to female MZ twins, is X-chromosome inactivation. Some MZ female twin pairs are discordant for monogenic X linked disorders because of differential X inactivation. We postulated that similar mechanisms may also occur in disorders with more complex inheritance including BD and SZ. Examination of X-chromosome inactivation patterns in DNA samples from blood and/or buccal swabs in a series of 63 female MZ twin pairs concordant or discordant for BD or SZ and healthy MZ controls suggests a potential contribution from X-linked loci to discordance within twin pairs for BD but is inconclusive for SZ. Discordant female bipolar twins showed greater differences in the methylation of the maternal and paternal X alleles than concordant twin pairs and suggest that differential skewing of X-chromosome inactivation may contribute to the discordance observed for bipolar disorder in female MZ twin pairs and the potential involvement of X-linked loci in the disorder. © 2007 Wiley-Liss, Inc.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/en_HK
dc.relation.ispartofAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Geneticsen_HK
dc.subjectBipolar disorderen_HK
dc.subjectPsychosisen_HK
dc.subjectTwinsen_HK
dc.subjectX-chromosome inactivationen_HK
dc.subjectX-linkageen_HK
dc.titleDifferential methylation of the X-chromosome is a possible source of discordance for bipolar disorder female monozygotic twinsen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ajmg.b.30616en_HK
dc.identifier.pmid17955481-
dc.identifier.scopuseid_2-s2.0-45149127401en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-45149127401&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume147en_HK
dc.identifier.issue4en_HK
dc.identifier.spage459en_HK
dc.identifier.epage462en_HK
dc.identifier.eissn1552-485X-
dc.identifier.isiWOS:000256331000008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridRosa, A=7201498717en_HK
dc.identifier.scopusauthoridPicchioni, MM=6507443795en_HK
dc.identifier.scopusauthoridKalidindi, S=24366595400en_HK
dc.identifier.scopusauthoridLoat, CS=6506983868en_HK
dc.identifier.scopusauthoridKnight, J=13002769800en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridVonk, R=7006104027en_HK
dc.identifier.scopusauthoridVan Der Schot, AC=16644176500en_HK
dc.identifier.scopusauthoridNolen, W=7006047458en_HK
dc.identifier.scopusauthoridKahn, RS=7201463706en_HK
dc.identifier.scopusauthoridMcGuffin, P=22954119700en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridCraig, IW=7102548208en_HK

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