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Article: Brief research communication: PRODH gene is associated with executive function in schizophrenic families

TitleBrief research communication: PRODH gene is associated with executive function in schizophrenic families
Authors
KeywordsCOMT
Executive function
PRODH
Quantita
Schizophrenia
Tive traits
Issue Date2008
Citation
American Journal Of Medical Genetics, Part B: Neuropsychiatric Genetics, 2008, v. 147 n. 5, p. 654-657 How to Cite?
AbstractThe aim of this study was to investigate the relationship between polymorphisms in the PRODH and COMT genes and selected neurocognitive functions. Six SNPs in PRODH and two SNPs in COMT were genotyped in 167 first-episode schizophrenic families who had been assessed by a set of 14 neuropsychological tests. Neuropsychological measures were selected as quantitative traits for association analysis. The haplotype of SNPs PRODH 1945T/C and PRODH 1852G/A was associated with impaired performance on the Tower of Hanoi, a problem-solving task mainly reflecting planning capacity. There was no significant evidence for association with any other neuropsychological traits for other SNPs or haplotypes of paired SNPs in the two genes. This study takes previous findings of association between PRODH and schizophrenia further by associating variation within the gene with performance on a neurocognitive trait characteristic of the illness. It fails to confirm previous reports of an association between COMT and cognitive function. © 2007 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/141846
ISSN
2015 SCImago Journal Rankings: 1.771
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Ten_HK
dc.contributor.authorMa, Xen_HK
dc.contributor.authorHu, Xen_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorYan, Cen_HK
dc.contributor.authorMeng, Hen_HK
dc.contributor.authorLiu, Xen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorCollier, DAen_HK
dc.date.accessioned2011-09-27T03:03:11Z-
dc.date.available2011-09-27T03:03:11Z-
dc.date.issued2008en_HK
dc.identifier.citationAmerican Journal Of Medical Genetics, Part B: Neuropsychiatric Genetics, 2008, v. 147 n. 5, p. 654-657en_HK
dc.identifier.issn1552-485Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/141846-
dc.description.abstractThe aim of this study was to investigate the relationship between polymorphisms in the PRODH and COMT genes and selected neurocognitive functions. Six SNPs in PRODH and two SNPs in COMT were genotyped in 167 first-episode schizophrenic families who had been assessed by a set of 14 neuropsychological tests. Neuropsychological measures were selected as quantitative traits for association analysis. The haplotype of SNPs PRODH 1945T/C and PRODH 1852G/A was associated with impaired performance on the Tower of Hanoi, a problem-solving task mainly reflecting planning capacity. There was no significant evidence for association with any other neuropsychological traits for other SNPs or haplotypes of paired SNPs in the two genes. This study takes previous findings of association between PRODH and schizophrenia further by associating variation within the gene with performance on a neurocognitive trait characteristic of the illness. It fails to confirm previous reports of an association between COMT and cognitive function. © 2007 Wiley-Liss, Inc.en_HK
dc.languageengen_US
dc.relation.ispartofAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Geneticsen_HK
dc.subjectCOMTen_HK
dc.subjectExecutive functionen_HK
dc.subjectPRODHen_HK
dc.subjectQuantitaen_HK
dc.subjectSchizophreniaen_HK
dc.subjectTive traitsen_HK
dc.titleBrief research communication: PRODH gene is associated with executive function in schizophrenic familiesen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ajmg.b.30648en_HK
dc.identifier.pmid18163391-
dc.identifier.scopuseid_2-s2.0-46949090461en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-46949090461&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume147en_HK
dc.identifier.issue5en_HK
dc.identifier.spage654en_HK
dc.identifier.epage657en_HK
dc.identifier.eissn1552-485X-
dc.identifier.isiWOS:000257447000017-
dc.identifier.scopusauthoridLi, T=36072008200en_HK
dc.identifier.scopusauthoridMa, X=35354066000en_HK
dc.identifier.scopusauthoridHu, X=7404709241en_HK
dc.identifier.scopusauthoridWang, Y=7601517986en_HK
dc.identifier.scopusauthoridYan, C=24464486100en_HK
dc.identifier.scopusauthoridMeng, H=9133658800en_HK
dc.identifier.scopusauthoridLiu, X=7409286408en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridCollier, DA=26642980600en_HK

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