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Article: Twins discordant for schizophrenia: Psychopathology of the non-schizophrenic co-twins

TitleTwins discordant for schizophrenia: Psychopathology of the non-schizophrenic co-twins
Authors
KeywordsAnxiety disorder
Depression
Schizophrenia
Twin study
Issue Date2008
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ACP
Citation
Acta Psychiatrica Scandinavica, 2008, v. 118 n. 3, p. 214-219 How to Cite?
AbstractObjective: Patients with schizophrenia are more likely to suffer from mood and anxiety disorders compared with the general population. We explored the aetiology of this comorbidity using a twin study design. Method: We applied an additive genetic + unique environment (AE) random effects model in the analysis of 35 non-schizophrenic co-twins from pairs discordant for schizophrenia, and 131 control twins. Results: Non-schizophrenic co-twins had significantly increased rates of depression (P = 0.006) and anxiety disorders (P = 0.021) compared with the control twins. Conclusion: Our results provide evidence for a familial association between schizophrenia and anxiety and depression. This could reflect common aetiological factors contributing to each of the disorders. Future studies should attempt to investigate the relative genetic and environmental contribution to the shared risk factors for schizophrenia, mood and anxiety disorders. Copyright © 2008 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/141843
ISSN
2015 Impact Factor: 6.128
2015 SCImago Journal Rankings: 2.518
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorArgyropoulos, SVen_HK
dc.contributor.authorLandau, Sen_HK
dc.contributor.authorKalidindi, Sen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorCastle, DJen_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorPicchioni, MMen_HK
dc.date.accessioned2011-09-27T03:03:05Z-
dc.date.available2011-09-27T03:03:05Z-
dc.date.issued2008en_HK
dc.identifier.citationActa Psychiatrica Scandinavica, 2008, v. 118 n. 3, p. 214-219en_HK
dc.identifier.issn0001-690Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/141843-
dc.description.abstractObjective: Patients with schizophrenia are more likely to suffer from mood and anxiety disorders compared with the general population. We explored the aetiology of this comorbidity using a twin study design. Method: We applied an additive genetic + unique environment (AE) random effects model in the analysis of 35 non-schizophrenic co-twins from pairs discordant for schizophrenia, and 131 control twins. Results: Non-schizophrenic co-twins had significantly increased rates of depression (P = 0.006) and anxiety disorders (P = 0.021) compared with the control twins. Conclusion: Our results provide evidence for a familial association between schizophrenia and anxiety and depression. This could reflect common aetiological factors contributing to each of the disorders. Future studies should attempt to investigate the relative genetic and environmental contribution to the shared risk factors for schizophrenia, mood and anxiety disorders. Copyright © 2008 The Authors.en_HK
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ACPen_HK
dc.relation.ispartofActa Psychiatrica Scandinavicaen_HK
dc.subjectAnxiety disorderen_HK
dc.subjectDepressionen_HK
dc.subjectSchizophreniaen_HK
dc.subjectTwin studyen_HK
dc.titleTwins discordant for schizophrenia: Psychopathology of the non-schizophrenic co-twinsen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1600-0447.2008.01205.xen_HK
dc.identifier.pmid18498431-
dc.identifier.scopuseid_2-s2.0-48749127376en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-48749127376&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume118en_HK
dc.identifier.issue3en_HK
dc.identifier.spage214en_HK
dc.identifier.epage219en_HK
dc.identifier.eissn1600-0447-
dc.identifier.isiWOS:000258194000006-
dc.publisher.placeDenmarken_HK
dc.identifier.f10001123955-
dc.identifier.scopusauthoridArgyropoulos, SV=7006064020en_HK
dc.identifier.scopusauthoridLandau, S=7101776972en_HK
dc.identifier.scopusauthoridKalidindi, S=24366595400en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridCastle, DJ=16149153500en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridPicchioni, MM=6507443795en_HK
dc.identifier.citeulike3097628-

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