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Article: Disruption of the neurexin 1 gene is associated with schizophrenia
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TitleDisruption of the neurexin 1 gene is associated with schizophrenia
 
AuthorsRujescu, D2
Ingason, A1 11
Cichon, S5
Pietiläinen, OPH15
Barnes, MR12
Toulopoulou, T3
Picchioni, M3
Vassos, E3
Ettinger, U3
Bramon, E3
Murray, R3
Ruggeri, M21
Tosato, S21
Bonetto, C21
Steinberg, S11
Sigurdsson, E8
Sigmundsson, T8
Petursson, H8
Gylfason, A11
Olason, PI11
Hardarsson, G11
Jonsdottir, GA11
Gustafsson, O11
Fossdal, R11
Giegling, I2
Möller, HJ2
Hartmann, AM2
Hoffmann, P5
Crombie, C6
Fraser, G6
Walker, N16
Lonnqvist, J15
Suvisaari, J15
TuulioHenriksson, A15
Djurovic, S19 9
Melle, I19 9
Andreassen, OA19 9
Hansen, T1
Werge, T1
Kiemeney, LA18
Franke, B18
Veltman, J18
BuizerVoskamp, JE4
Sabatti, C20
Ophoff, RA4 20
Rietschel, M13
Nöthen, MM5
Stefansson, K2
Peltonen, L23 14 15 9
St Clair, D6
Stefansson, H11
Collier, DA3
Kahn, RS22
Linszen, D7
von Os, J17
Wiersma, D10
Bruggeman, R10
Cahn, W22
de Haan, L7
Krabbendam, L17
MyinGermeys, I17
 
KeywordsMolecular Sequence Numbers
 
Issue Date2009
 
PublisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
 
CitationHuman Molecular Genetics, 2009, v. 18 n. 5, p. 988-996 [How to Cite?]
DOI: http://dx.doi.org/10.1093/hmg/ddn351
 
AbstractDeletions within the neurexin 1 gene (NRXN1; 2p16.3) are associated with autism and have also been reported in two families with schizophrenia. We examined NRXN1, and the closely related NRXN2 and NRXN3 genes, for copy number variants (CNVs) in 2977 schizophrenia patients and 33 746 controls from seven European populations (Iceland, Finland, Norway, Germany, The Netherlands, Italy and UK) using microarray data. We found 66 deletions and 5 duplications in NRXN1, including a de novo deletion: 12 deletions and 2 duplications occurred in schizophrenia cases (0.47%) compared to 49 and 3 (0.15%) in controls. There was no common breakpoint and the CNVs varied from 18 to 420 kb. No CNVs were found in NRXN2 or NRXN3. We performed a Cochran-Mantel-Haenszel exact test to estimate association between all CNVs and schizophrenia (P = 0.13; OR = 1.73; 95% CI 0.81-3.50). Because the penetrance of NRXN1 CNVs may vary according to the level of functional impact on the gene, we next restricted the association analysis to CNVs that disrupt exons (0.24% of cases and 0.015% of controls). These were significantly associated with a high odds ratio (P = 0.0027; OR 8.97, 95% CI 1.8-51.9). We conclude that NRXN1 deletions affecting exons confer risk of schizophrenia. © The Author 2008. Published by Oxford University Press. All rights reserved.
 
ISSN0964-6906
2013 Impact Factor: 6.677
 
DOIhttp://dx.doi.org/10.1093/hmg/ddn351
 
PubMed Central IDPMC2695245
 
ISI Accession Number IDWOS:000263409100017
Funding AgencyGrant Number
EULSHM-CT-2006037761
Funding Information:

This work was sponsored by EU grant LSHM-CT-2006037761 (Project SGENE).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorRujescu, D
 
dc.contributor.authorIngason, A
 
dc.contributor.authorCichon, S
 
dc.contributor.authorPietiläinen, OPH
 
dc.contributor.authorBarnes, MR
 
dc.contributor.authorToulopoulou, T
 
dc.contributor.authorPicchioni, M
 
dc.contributor.authorVassos, E
 
dc.contributor.authorEttinger, U
 
dc.contributor.authorBramon, E
 
dc.contributor.authorMurray, R
 
dc.contributor.authorRuggeri, M
 
dc.contributor.authorTosato, S
 
dc.contributor.authorBonetto, C
 
dc.contributor.authorSteinberg, S
 
dc.contributor.authorSigurdsson, E
 
dc.contributor.authorSigmundsson, T
 
dc.contributor.authorPetursson, H
 
dc.contributor.authorGylfason, A
 
dc.contributor.authorOlason, PI
 
dc.contributor.authorHardarsson, G
 
dc.contributor.authorJonsdottir, GA
 
dc.contributor.authorGustafsson, O
 
dc.contributor.authorFossdal, R
 
dc.contributor.authorGiegling, I
 
dc.contributor.authorMöller, HJ
 
dc.contributor.authorHartmann, AM
 
dc.contributor.authorHoffmann, P
 
dc.contributor.authorCrombie, C
 
dc.contributor.authorFraser, G
 
dc.contributor.authorWalker, N
 
dc.contributor.authorLonnqvist, J
 
dc.contributor.authorSuvisaari, J
 
dc.contributor.authorTuulioHenriksson, A
 
dc.contributor.authorDjurovic, S
 
dc.contributor.authorMelle, I
 
dc.contributor.authorAndreassen, OA
 
dc.contributor.authorHansen, T
 
dc.contributor.authorWerge, T
 
dc.contributor.authorKiemeney, LA
 
dc.contributor.authorFranke, B
 
dc.contributor.authorVeltman, J
 
dc.contributor.authorBuizerVoskamp, JE
 
dc.contributor.authorSabatti, C
 
dc.contributor.authorOphoff, RA
 
dc.contributor.authorRietschel, M
 
dc.contributor.authorNöthen, MM
 
dc.contributor.authorStefansson, K
 
dc.contributor.authorPeltonen, L
 
dc.contributor.authorSt Clair, D
 
dc.contributor.authorStefansson, H
 
dc.contributor.authorCollier, DA
 
dc.contributor.authorKahn, RS
 
dc.contributor.authorLinszen, D
 
dc.contributor.authorvon Os, J
 
dc.contributor.authorWiersma, D
 
dc.contributor.authorBruggeman, R
 
dc.contributor.authorCahn, W
 
dc.contributor.authorde Haan, L
 
dc.contributor.authorKrabbendam, L
 
dc.contributor.authorMyinGermeys, I
 
dc.date.accessioned2011-09-27T03:03:03Z
 
dc.date.available2011-09-27T03:03:03Z
 
dc.date.issued2009
 
dc.description.abstractDeletions within the neurexin 1 gene (NRXN1; 2p16.3) are associated with autism and have also been reported in two families with schizophrenia. We examined NRXN1, and the closely related NRXN2 and NRXN3 genes, for copy number variants (CNVs) in 2977 schizophrenia patients and 33 746 controls from seven European populations (Iceland, Finland, Norway, Germany, The Netherlands, Italy and UK) using microarray data. We found 66 deletions and 5 duplications in NRXN1, including a de novo deletion: 12 deletions and 2 duplications occurred in schizophrenia cases (0.47%) compared to 49 and 3 (0.15%) in controls. There was no common breakpoint and the CNVs varied from 18 to 420 kb. No CNVs were found in NRXN2 or NRXN3. We performed a Cochran-Mantel-Haenszel exact test to estimate association between all CNVs and schizophrenia (P = 0.13; OR = 1.73; 95% CI 0.81-3.50). Because the penetrance of NRXN1 CNVs may vary according to the level of functional impact on the gene, we next restricted the association analysis to CNVs that disrupt exons (0.24% of cases and 0.015% of controls). These were significantly associated with a high odds ratio (P = 0.0027; OR 8.97, 95% CI 1.8-51.9). We conclude that NRXN1 deletions affecting exons confer risk of schizophrenia. © The Author 2008. Published by Oxford University Press. All rights reserved.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationHuman Molecular Genetics, 2009, v. 18 n. 5, p. 988-996 [How to Cite?]
DOI: http://dx.doi.org/10.1093/hmg/ddn351
 
dc.identifier.citeulike3459843
 
dc.identifier.doihttp://dx.doi.org/10.1093/hmg/ddn351
 
dc.identifier.eissn1460-2083
 
dc.identifier.epage996
 
dc.identifier.f10001164831
 
dc.identifier.f10001164831
 
dc.identifier.isiWOS:000263409100017
Funding AgencyGrant Number
EULSHM-CT-2006037761
Funding Information:

This work was sponsored by EU grant LSHM-CT-2006037761 (Project SGENE).

 
dc.identifier.issn0964-6906
2013 Impact Factor: 6.677
 
dc.identifier.issue5
 
dc.identifier.pmcidPMC2695245
 
dc.identifier.pmid18945720
 
dc.identifier.scopuseid_2-s2.0-60549106509
 
dc.identifier.spage988
 
dc.identifier.urihttp://hdl.handle.net/10722/141840
 
dc.identifier.volume18
 
dc.languageeng
 
dc.publisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofHuman Molecular Genetics
 
dc.relation.referencesReferences in Scopus
 
dc.subjectMolecular Sequence Numbers
 
dc.titleDisruption of the neurexin 1 gene is associated with schizophrenia
 
dc.typeArticle
 
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Author Affiliations
  1. Copenhagen University Hospital
  2. Ludwig-Maximilians-Universität München
  3. King's College London
  4. Rudolf Magnus Institute of Neuroscience
  5. Universität Bonn
  6. University of Aberdeen
  7. Academic Medical Centre, University of Amsterdam
  8. National University Hospital Reykjavik
  9. Ulleval University Hospital
  10. Universitair Medisch Centrum Groningen
  11. deCODE Genetics
  12. GlaxoSmithKline
  13. Universität Heidelberg
  14. Wellcome Trust Sanger Institute
  15. Kansanterveyslaitos
  16. Ravenscraig Hospital
  17. Maastricht University
  18. Radboud University Nijmegen
  19. Universitetet i Oslo
  20. University of California, Los Angeles
  21. Università degli Studi di Verona
  22. University Medical Center Utrecht
  23. Broad Institute