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Article: Disruption of the neurexin 1 gene is associated with schizophrenia

TitleDisruption of the neurexin 1 gene is associated with schizophrenia
Authors
KeywordsMolecular Sequence Numbers
Issue Date2009
PublisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
Citation
Human Molecular Genetics, 2009, v. 18 n. 5, p. 988-996 How to Cite?
Abstract
Deletions within the neurexin 1 gene (NRXN1; 2p16.3) are associated with autism and have also been reported in two families with schizophrenia. We examined NRXN1, and the closely related NRXN2 and NRXN3 genes, for copy number variants (CNVs) in 2977 schizophrenia patients and 33 746 controls from seven European populations (Iceland, Finland, Norway, Germany, The Netherlands, Italy and UK) using microarray data. We found 66 deletions and 5 duplications in NRXN1, including a de novo deletion: 12 deletions and 2 duplications occurred in schizophrenia cases (0.47%) compared to 49 and 3 (0.15%) in controls. There was no common breakpoint and the CNVs varied from 18 to 420 kb. No CNVs were found in NRXN2 or NRXN3. We performed a Cochran-Mantel-Haenszel exact test to estimate association between all CNVs and schizophrenia (P = 0.13; OR = 1.73; 95% CI 0.81-3.50). Because the penetrance of NRXN1 CNVs may vary according to the level of functional impact on the gene, we next restricted the association analysis to CNVs that disrupt exons (0.24% of cases and 0.015% of controls). These were significantly associated with a high odds ratio (P = 0.0027; OR 8.97, 95% CI 1.8-51.9). We conclude that NRXN1 deletions affecting exons confer risk of schizophrenia. © The Author 2008. Published by Oxford University Press. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/141840
ISSN
2013 Impact Factor: 6.677
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
EULSHM-CT-2006037761
Funding Information:

This work was sponsored by EU grant LSHM-CT-2006037761 (Project SGENE).

References

 

Author Affiliations
  1. Copenhagen University Hospital
  2. Ludwig-Maximilians-Universität München
  3. King's College London
  4. Rudolf Magnus Institute of Neuroscience
  5. Universität Bonn
  6. University of Aberdeen
  7. Academic Medical Centre, University of Amsterdam
  8. National University Hospital Reykjavik
  9. Ulleval University Hospital
  10. Universitair Medisch Centrum Groningen
  11. deCODE Genetics
  12. GlaxoSmithKline
  13. Universität Heidelberg
  14. Wellcome Trust Sanger Institute
  15. Kansanterveyslaitos
  16. Ravenscraig Hospital
  17. Maastricht University
  18. Radboud University Nijmegen
  19. Universitetet i Oslo
  20. University of California, Los Angeles
  21. Università degli Studi di Verona
  22. University Medical Center Utrecht
  23. Broad Institute
DC FieldValueLanguage
dc.contributor.authorRujescu, Den_HK
dc.contributor.authorIngason, Aen_HK
dc.contributor.authorCichon, Sen_HK
dc.contributor.authorPietiläinen, OPHen_HK
dc.contributor.authorBarnes, MRen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorPicchioni, Men_HK
dc.contributor.authorVassos, Een_HK
dc.contributor.authorEttinger, Uen_HK
dc.contributor.authorBramon, Een_HK
dc.contributor.authorMurray, Ren_HK
dc.contributor.authorRuggeri, Men_HK
dc.contributor.authorTosato, Sen_HK
dc.contributor.authorBonetto, Cen_HK
dc.contributor.authorSteinberg, Sen_HK
dc.contributor.authorSigurdsson, Een_HK
dc.contributor.authorSigmundsson, Ten_HK
dc.contributor.authorPetursson, Hen_HK
dc.contributor.authorGylfason, Aen_HK
dc.contributor.authorOlason, PIen_HK
dc.contributor.authorHardarsson, Gen_HK
dc.contributor.authorJonsdottir, GAen_HK
dc.contributor.authorGustafsson, Oen_HK
dc.contributor.authorFossdal, Ren_HK
dc.contributor.authorGiegling, Ien_HK
dc.contributor.authorMöller, HJen_HK
dc.contributor.authorHartmann, AMen_HK
dc.contributor.authorHoffmann, Pen_HK
dc.contributor.authorCrombie, Cen_HK
dc.contributor.authorFraser, Gen_HK
dc.contributor.authorWalker, Nen_HK
dc.contributor.authorLonnqvist, Jen_HK
dc.contributor.authorSuvisaari, Jen_HK
dc.contributor.authorTuulioHenriksson, Aen_HK
dc.contributor.authorDjurovic, Sen_HK
dc.contributor.authorMelle, Ien_HK
dc.contributor.authorAndreassen, OAen_HK
dc.contributor.authorHansen, Ten_HK
dc.contributor.authorWerge, Ten_HK
dc.contributor.authorKiemeney, LAen_HK
dc.contributor.authorFranke, Ben_HK
dc.contributor.authorVeltman, Jen_HK
dc.contributor.authorBuizerVoskamp, JEen_HK
dc.contributor.authorSabatti, Cen_HK
dc.contributor.authorOphoff, RAen_HK
dc.contributor.authorRietschel, Men_HK
dc.contributor.authorNöthen, MMen_HK
dc.contributor.authorStefansson, Ken_HK
dc.contributor.authorPeltonen, Len_HK
dc.contributor.authorSt Clair, Den_HK
dc.contributor.authorStefansson, Hen_HK
dc.contributor.authorCollier, DAen_HK
dc.contributor.authorKahn, RSen_HK
dc.contributor.authorLinszen, Den_HK
dc.contributor.authorvon Os, Jen_HK
dc.contributor.authorWiersma, Den_HK
dc.contributor.authorBruggeman, Ren_HK
dc.contributor.authorCahn, Wen_HK
dc.contributor.authorde Haan, Len_HK
dc.contributor.authorKrabbendam, Len_HK
dc.contributor.authorMyinGermeys, Ien_HK
dc.date.accessioned2011-09-27T03:03:03Z-
dc.date.available2011-09-27T03:03:03Z-
dc.date.issued2009en_HK
dc.identifier.citationHuman Molecular Genetics, 2009, v. 18 n. 5, p. 988-996en_HK
dc.identifier.issn0964-6906en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141840-
dc.description.abstractDeletions within the neurexin 1 gene (NRXN1; 2p16.3) are associated with autism and have also been reported in two families with schizophrenia. We examined NRXN1, and the closely related NRXN2 and NRXN3 genes, for copy number variants (CNVs) in 2977 schizophrenia patients and 33 746 controls from seven European populations (Iceland, Finland, Norway, Germany, The Netherlands, Italy and UK) using microarray data. We found 66 deletions and 5 duplications in NRXN1, including a de novo deletion: 12 deletions and 2 duplications occurred in schizophrenia cases (0.47%) compared to 49 and 3 (0.15%) in controls. There was no common breakpoint and the CNVs varied from 18 to 420 kb. No CNVs were found in NRXN2 or NRXN3. We performed a Cochran-Mantel-Haenszel exact test to estimate association between all CNVs and schizophrenia (P = 0.13; OR = 1.73; 95% CI 0.81-3.50). Because the penetrance of NRXN1 CNVs may vary according to the level of functional impact on the gene, we next restricted the association analysis to CNVs that disrupt exons (0.24% of cases and 0.015% of controls). These were significantly associated with a high odds ratio (P = 0.0027; OR 8.97, 95% CI 1.8-51.9). We conclude that NRXN1 deletions affecting exons confer risk of schizophrenia. © The Author 2008. Published by Oxford University Press. All rights reserved.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/en_HK
dc.relation.ispartofHuman Molecular Geneticsen_HK
dc.subjectMolecular Sequence Numbersen_US
dc.titleDisruption of the neurexin 1 gene is associated with schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1093/hmg/ddn351en_HK
dc.identifier.pmid18945720en_HK
dc.identifier.pmcidPMC2695245-
dc.identifier.scopuseid_2-s2.0-60549106509en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-60549106509&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue5en_HK
dc.identifier.spage988en_HK
dc.identifier.epage996en_HK
dc.identifier.eissn1460-2083-
dc.identifier.isiWOS:000263409100017-
dc.publisher.placeUnited Kingdomen_HK
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dc.identifier.scopusauthoridRujescu, D=6701768114en_HK
dc.identifier.scopusauthoridIngason, A=22734427200en_HK
dc.identifier.scopusauthoridCichon, S=7005957855en_HK
dc.identifier.scopusauthoridPietiläinen, OPH=35262502200en_HK
dc.identifier.scopusauthoridBarnes, MR=35498112100en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridPicchioni, M=6507443795en_HK
dc.identifier.scopusauthoridVassos, E=35369293900en_HK
dc.identifier.scopusauthoridEttinger, U=6602766172en_HK
dc.identifier.scopusauthoridBramon, E=8089378900en_HK
dc.identifier.scopusauthoridMurray, R=35406239400en_HK
dc.identifier.scopusauthoridRuggeri, M=7005660435en_HK
dc.identifier.scopusauthoridTosato, S=8672074400en_HK
dc.identifier.scopusauthoridBonetto, C=6701682315en_HK
dc.identifier.scopusauthoridSteinberg, S=22735361200en_HK
dc.identifier.scopusauthoridSigurdsson, E=7004378235en_HK
dc.identifier.scopusauthoridSigmundsson, T=6602171613en_HK
dc.identifier.scopusauthoridPetursson, H=7003947853en_HK
dc.identifier.scopusauthoridGylfason, A=8121806200en_HK
dc.identifier.scopusauthoridOlason, PI=8547202600en_HK
dc.identifier.scopusauthoridHardarsson, G=36123042100en_HK
dc.identifier.scopusauthoridJonsdottir, GA=20734633400en_HK
dc.identifier.scopusauthoridGustafsson, O=26023239200en_HK
dc.identifier.scopusauthoridFossdal, R=35326461300en_HK
dc.identifier.scopusauthoridGiegling, I=6602186623en_HK
dc.identifier.scopusauthoridMöller, HJ=7401855577en_HK
dc.identifier.scopusauthoridHartmann, AM=7402943568en_HK
dc.identifier.scopusauthoridHoffmann, P=35242500200en_HK
dc.identifier.scopusauthoridCrombie, C=12240136900en_HK
dc.identifier.scopusauthoridFraser, G=34770971900en_HK
dc.identifier.scopusauthoridWalker, N=7201514664en_HK
dc.identifier.scopusauthoridLonnqvist, J=35234007300en_HK
dc.identifier.scopusauthoridSuvisaari, J=35238930800en_HK
dc.identifier.scopusauthoridTuulioHenriksson, A=35235635600en_HK
dc.identifier.scopusauthoridDjurovic, S=7003849042en_HK
dc.identifier.scopusauthoridMelle, I=6603091220en_HK
dc.identifier.scopusauthoridAndreassen, OA=7005761947en_HK
dc.identifier.scopusauthoridHansen, T=7401667958en_HK
dc.identifier.scopusauthoridWerge, T=6701738296en_HK
dc.identifier.scopusauthoridKiemeney, LA=7005158534en_HK
dc.identifier.scopusauthoridFranke, B=7005326255en_HK
dc.identifier.scopusauthoridVeltman, J=7003517626en_HK
dc.identifier.scopusauthoridBuizerVoskamp, JE=24780588900en_HK
dc.identifier.scopusauthoridSabatti, C=6603090683en_HK
dc.identifier.scopusauthoridOphoff, RA=7004321340en_HK
dc.identifier.scopusauthoridRietschel, M=7006620620en_HK
dc.identifier.scopusauthoridNöthen, MM=35355123900en_HK
dc.identifier.scopusauthoridStefansson, K=7005997553en_HK
dc.identifier.scopusauthoridPeltonen, L=36051313500en_HK
dc.identifier.scopusauthoridSt Clair, D=35354078200en_HK
dc.identifier.scopusauthoridStefansson, H=6604083232en_HK
dc.identifier.scopusauthoridCollier, DA=26642980600en_HK
dc.identifier.scopusauthoridKahn, RS=7201463706en_HK
dc.identifier.scopusauthoridLinszen, D=7007173948en_HK
dc.identifier.scopusauthoridvon Os, J=36124364900en_HK
dc.identifier.scopusauthoridWiersma, D=7101791155en_HK
dc.identifier.scopusauthoridBruggeman, R=22933600300en_HK
dc.identifier.scopusauthoridCahn, W=6603045753en_HK
dc.identifier.scopusauthoridde Haan, L=7005592387en_HK
dc.identifier.scopusauthoridKrabbendam, L=6604013856en_HK
dc.identifier.scopusauthoridMyinGermeys, I=6603917483en_HK
dc.identifier.citeulike3459843-

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