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Article: White matter microstructure in schizophrenia: Effects of disorder, duration and medication

TitleWhite matter microstructure in schizophrenia: Effects of disorder, duration and medication
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2009
PublisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/
Citation
British Journal Of Psychiatry, 2009, v. 194 n. 3, p. 236-242 How to Cite?
AbstractBackground Diffusion tensor magnetic resonance imaging studies in schizophrenia to date have been largely inconsistent. This may reflect variation in methodology, and the use of small samples with differing illness duration and medication exposure. Aims To determine the extent and location of white matter microstructural changes in schizophrenia, using optimised diffusion tensor imaging in a large patient sample, and to consider the effects of illness duration and medication exposure. Method Scans from 76 patients with schizophrenia and 76 matched controls were used to compare fractional anisotropy, a measure of white matter microstructural integrity, between the groups. Results We found widespread clusters of reduced fractional anisotropy in patients, affecting most major white matter tracts. These reductions did not correlate with iliness duration, and there was no difference between age-matched chronically and briefly medicated patients. Conclusions The finding of widespread fractional anisotropy reductions in our larger sample of patients with schizophrenia may explain some of the inconsistent findings of previous, smaller studies.
Persistent Identifierhttp://hdl.handle.net/10722/141839
ISSN
2015 Impact Factor: 7.06
2015 SCImago Journal Rankings: 2.674
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKanaan, Ren_HK
dc.contributor.authorBarker, Gen_HK
dc.contributor.authorBrammer, Men_HK
dc.contributor.authorGiampietro, Ven_HK
dc.contributor.authorShergill, Sen_HK
dc.contributor.authorWoolley, Jen_HK
dc.contributor.authorPicchioni, Men_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorMcGuire, Pen_HK
dc.date.accessioned2011-09-27T03:03:00Z-
dc.date.available2011-09-27T03:03:00Z-
dc.date.issued2009en_HK
dc.identifier.citationBritish Journal Of Psychiatry, 2009, v. 194 n. 3, p. 236-242en_HK
dc.identifier.issn0007-1250en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141839-
dc.description.abstractBackground Diffusion tensor magnetic resonance imaging studies in schizophrenia to date have been largely inconsistent. This may reflect variation in methodology, and the use of small samples with differing illness duration and medication exposure. Aims To determine the extent and location of white matter microstructural changes in schizophrenia, using optimised diffusion tensor imaging in a large patient sample, and to consider the effects of illness duration and medication exposure. Method Scans from 76 patients with schizophrenia and 76 matched controls were used to compare fractional anisotropy, a measure of white matter microstructural integrity, between the groups. Results We found widespread clusters of reduced fractional anisotropy in patients, affecting most major white matter tracts. These reductions did not correlate with iliness duration, and there was no difference between age-matched chronically and briefly medicated patients. Conclusions The finding of widespread fractional anisotropy reductions in our larger sample of patients with schizophrenia may explain some of the inconsistent findings of previous, smaller studies.en_HK
dc.languageengen_US
dc.publisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/en_HK
dc.relation.ispartofBritish Journal of Psychiatryen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.titleWhite matter microstructure in schizophrenia: Effects of disorder, duration and medicationen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1192/bjp.bp.108.054320en_HK
dc.identifier.pmid19252154-
dc.identifier.pmcidPMC2802507-
dc.identifier.scopuseid_2-s2.0-62149090215en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-62149090215&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume194en_HK
dc.identifier.issue3en_HK
dc.identifier.spage236en_HK
dc.identifier.epage242en_HK
dc.identifier.eissn1472-1465-
dc.identifier.isiWOS:000264387100008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKanaan, R=12545783400en_HK
dc.identifier.scopusauthoridBarker, G=34869208000en_HK
dc.identifier.scopusauthoridBrammer, M=7006746119en_HK
dc.identifier.scopusauthoridGiampietro, V=6602160284en_HK
dc.identifier.scopusauthoridShergill, S=35433190700en_HK
dc.identifier.scopusauthoridWoolley, J=7102945377en_HK
dc.identifier.scopusauthoridPicchioni, M=6507443795en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridMcGuire, P=7101880438en_HK
dc.identifier.citeulike7093234-

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