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Article: Memory functioning in familial bipolar I disorder patients and their relatives
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TitleMemory functioning in familial bipolar I disorder patients and their relatives
 
AuthorsQuraishi, S2
Walshe, M2
Mcdonald, C2 3
Schulze, K2
Kravariti, E2 1
Bramon, E2
Morris, RG2
Murray, RM2
Toulopoulou, T2
 
KeywordsBipolar I disorder
Familial
Family study
First-degree relatives
Memory functioning
Psychosis
 
Issue Date2009
 
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BDI
 
CitationBipolar Disorders, 2009, v. 11 n. 2, p. 209-214 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1399-5618.2008.00661.x
 
AbstractObjectives: The aim of this study was to compare the memory function of patients with familial bipolar I disorder (BD I) who had shown psychotic features, their non-psychotic, non-bipolar first-degree relatives, and normal controls. Methods: We assessed 38 patients with a lifetime diagnosis of BD I who had experienced psychotic symptoms, 49 of their non-psychotic, non-bipolar first-degree relatives, and 44 controls. Patients and relatives were from families multiply affected with functional psychotic illness. A five-subtest short form of the Wechsler Adult Intelligence Scale-Revised and three Wechsler Memory Scale subtests were administered to all participants. Results: BD I patients showed deficits in verbal memory and verbal learning but not in visual memory. Compared to controls, relatives showed worse verbal learning at a statistically significant or suggestive level and performed significantly worse in both immediate and delayed verbal memory. Similar to patients, there were no differences between the relatives and control group for visual memory. Conclusiions: Impaired verbal memory and learning were found in patients and their relatives. These deficits may represent candidate endophenotypic markers for bipolar disorder. © 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard.
 
ISSN1398-5647
2012 Impact Factor: 4.621
2012 SCImago Journal Rankings: 2.546
 
DOIhttp://dx.doi.org/10.1111/j.1399-5618.2008.00661.x
 
ISI Accession Number IDWOS:000265185200011
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorQuraishi, S
 
dc.contributor.authorWalshe, M
 
dc.contributor.authorMcdonald, C
 
dc.contributor.authorSchulze, K
 
dc.contributor.authorKravariti, E
 
dc.contributor.authorBramon, E
 
dc.contributor.authorMorris, RG
 
dc.contributor.authorMurray, RM
 
dc.contributor.authorToulopoulou, T
 
dc.date.accessioned2011-09-27T03:02:59Z
 
dc.date.available2011-09-27T03:02:59Z
 
dc.date.issued2009
 
dc.description.abstractObjectives: The aim of this study was to compare the memory function of patients with familial bipolar I disorder (BD I) who had shown psychotic features, their non-psychotic, non-bipolar first-degree relatives, and normal controls. Methods: We assessed 38 patients with a lifetime diagnosis of BD I who had experienced psychotic symptoms, 49 of their non-psychotic, non-bipolar first-degree relatives, and 44 controls. Patients and relatives were from families multiply affected with functional psychotic illness. A five-subtest short form of the Wechsler Adult Intelligence Scale-Revised and three Wechsler Memory Scale subtests were administered to all participants. Results: BD I patients showed deficits in verbal memory and verbal learning but not in visual memory. Compared to controls, relatives showed worse verbal learning at a statistically significant or suggestive level and performed significantly worse in both immediate and delayed verbal memory. Similar to patients, there were no differences between the relatives and control group for visual memory. Conclusiions: Impaired verbal memory and learning were found in patients and their relatives. These deficits may represent candidate endophenotypic markers for bipolar disorder. © 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationBipolar Disorders, 2009, v. 11 n. 2, p. 209-214 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1399-5618.2008.00661.x
 
dc.identifier.citeulike4114218
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1399-5618.2008.00661.x
 
dc.identifier.eissn1399-5618
 
dc.identifier.epage214
 
dc.identifier.isiWOS:000265185200011
 
dc.identifier.issn1398-5647
2012 Impact Factor: 4.621
2012 SCImago Journal Rankings: 2.546
 
dc.identifier.issue2
 
dc.identifier.pmid19267704
 
dc.identifier.scopuseid_2-s2.0-61449102731
 
dc.identifier.spage209
 
dc.identifier.urihttp://hdl.handle.net/10722/141838
 
dc.identifier.volume11
 
dc.languageeng
 
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BDI
 
dc.publisher.placeDenmark
 
dc.relation.ispartofBipolar Disorders
 
dc.relation.referencesReferences in Scopus
 
dc.subjectBipolar I disorder
 
dc.subjectFamilial
 
dc.subjectFamily study
 
dc.subjectFirst-degree relatives
 
dc.subjectMemory functioning
 
dc.subjectPsychosis
 
dc.titleMemory functioning in familial bipolar I disorder patients and their relatives
 
dc.typeArticle
 
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<contributor.author>Schulze, K</contributor.author>
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Author Affiliations
  1. King's College London
  2. National Health Service
  3. National University of Ireland Galway