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Article: Memory functioning in familial bipolar I disorder patients and their relatives

TitleMemory functioning in familial bipolar I disorder patients and their relatives
Authors
KeywordsBipolar I disorder
Familial
Family study
First-degree relatives
Memory functioning
Psychosis
Issue Date2009
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BDI
Citation
Bipolar Disorders, 2009, v. 11 n. 2, p. 209-214 How to Cite?
Abstract
Objectives: The aim of this study was to compare the memory function of patients with familial bipolar I disorder (BD I) who had shown psychotic features, their non-psychotic, non-bipolar first-degree relatives, and normal controls. Methods: We assessed 38 patients with a lifetime diagnosis of BD I who had experienced psychotic symptoms, 49 of their non-psychotic, non-bipolar first-degree relatives, and 44 controls. Patients and relatives were from families multiply affected with functional psychotic illness. A five-subtest short form of the Wechsler Adult Intelligence Scale-Revised and three Wechsler Memory Scale subtests were administered to all participants. Results: BD I patients showed deficits in verbal memory and verbal learning but not in visual memory. Compared to controls, relatives showed worse verbal learning at a statistically significant or suggestive level and performed significantly worse in both immediate and delayed verbal memory. Similar to patients, there were no differences between the relatives and control group for visual memory. Conclusiions: Impaired verbal memory and learning were found in patients and their relatives. These deficits may represent candidate endophenotypic markers for bipolar disorder. © 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard.
Persistent Identifierhttp://hdl.handle.net/10722/141838
ISSN
2013 Impact Factor: 4.888
ISI Accession Number ID
References

 

Author Affiliations
  1. King's College London
  2. National Health Service
  3. National University of Ireland Galway
DC FieldValueLanguage
dc.contributor.authorQuraishi, Sen_HK
dc.contributor.authorWalshe, Men_HK
dc.contributor.authorMcdonald, Cen_HK
dc.contributor.authorSchulze, Ken_HK
dc.contributor.authorKravariti, Een_HK
dc.contributor.authorBramon, Een_HK
dc.contributor.authorMorris, RGen_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.date.accessioned2011-09-27T03:02:59Z-
dc.date.available2011-09-27T03:02:59Z-
dc.date.issued2009en_HK
dc.identifier.citationBipolar Disorders, 2009, v. 11 n. 2, p. 209-214en_HK
dc.identifier.issn1398-5647en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141838-
dc.description.abstractObjectives: The aim of this study was to compare the memory function of patients with familial bipolar I disorder (BD I) who had shown psychotic features, their non-psychotic, non-bipolar first-degree relatives, and normal controls. Methods: We assessed 38 patients with a lifetime diagnosis of BD I who had experienced psychotic symptoms, 49 of their non-psychotic, non-bipolar first-degree relatives, and 44 controls. Patients and relatives were from families multiply affected with functional psychotic illness. A five-subtest short form of the Wechsler Adult Intelligence Scale-Revised and three Wechsler Memory Scale subtests were administered to all participants. Results: BD I patients showed deficits in verbal memory and verbal learning but not in visual memory. Compared to controls, relatives showed worse verbal learning at a statistically significant or suggestive level and performed significantly worse in both immediate and delayed verbal memory. Similar to patients, there were no differences between the relatives and control group for visual memory. Conclusiions: Impaired verbal memory and learning were found in patients and their relatives. These deficits may represent candidate endophenotypic markers for bipolar disorder. © 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard.en_HK
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BDIen_HK
dc.relation.ispartofBipolar Disordersen_HK
dc.subjectBipolar I disorderen_HK
dc.subjectFamilialen_HK
dc.subjectFamily studyen_HK
dc.subjectFirst-degree relativesen_HK
dc.subjectMemory functioningen_HK
dc.subjectPsychosisen_HK
dc.titleMemory functioning in familial bipolar I disorder patients and their relativesen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1399-5618.2008.00661.xen_HK
dc.identifier.pmid19267704en_HK
dc.identifier.scopuseid_2-s2.0-61449102731en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-61449102731&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue2en_HK
dc.identifier.spage209en_HK
dc.identifier.epage214en_HK
dc.identifier.eissn1399-5618-
dc.identifier.isiWOS:000265185200011-
dc.publisher.placeDenmarken_HK
dc.identifier.scopusauthoridQuraishi, S=6603840181en_HK
dc.identifier.scopusauthoridWalshe, M=8855469300en_HK
dc.identifier.scopusauthoridMcdonald, C=8749594800en_HK
dc.identifier.scopusauthoridSchulze, K=7103137549en_HK
dc.identifier.scopusauthoridKravariti, E=8855469000en_HK
dc.identifier.scopusauthoridBramon, E=8089378900en_HK
dc.identifier.scopusauthoridMorris, RG=7404060505en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.citeulike4114218-

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