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Article: Neuropsychological correlates of eye movement abnormalities in schizophrenic patients and their unaffected relatives
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TitleNeuropsychological correlates of eye movement abnormalities in schizophrenic patients and their unaffected relatives
 
AuthorsZanelli, J1
MacCabe, J1
Toulopoulou, T1
Walshe, M1
McDonald, C1
Murray, R1
 
KeywordsAntisaccade
Eye movement
Neuropsychology
Schizophrenia
Smooth pursuit
 
Issue Date2009
 
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychres
 
CitationPsychiatry Research, 2009, v. 168 n. 3, p. 193-197 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.psychres.2008.05.008
 
AbstractImpairments on neuropsychological and eye movement tasks have been demonstrated in schizophrenic patients and also reported in their unaffected relatives. However, it is not clear to what extent these phenotypes overlap. This study examined the relationship between specific eye movement and neuropsychological measures. The relationship between performance on eye movement and neuropsychological tasks was measured in 79 schizophrenic patients (63% from multiply affected families), 129 of their healthy first-degree relatives, and 72 normal controls. Antisaccade scores were correlated with most measures of neurocognitive functioning, and this correlation was strongest in schizophrenic patients in all cases. In the schizophrenic patients, but not their relatives or controls, the antisaccade distractibility error (ADE) score correlated significantly with current intelligence, verbal memory (immediate and delayed recall), and associative learning. In the case of crystallised IQ and delayed verbal memory, smaller correlations were present in unaffected relatives, although neither survived Bonferroni correction. Smooth pursuit performance was unrelated to any neuropsychological measure. Our study suggests that antisaccade errors are likely to represent part of a generalized neuropsychological deficit in schizophrenia. © 2008 Elsevier Ireland Ltd. All rights reserved.
 
ISSN0165-1781
2012 Impact Factor: 2.456
2012 SCImago Journal Rankings: 1.194
 
DOIhttp://dx.doi.org/10.1016/j.psychres.2008.05.008
 
ISI Accession Number IDWOS:000269118700004
Funding AgencyGrant Number
Wellcome Trust
Stanley Medical Research Institute
Psychiatry Research Trust
Funding Information:

We would like to thank all the families who participated in the study and the Rethink, the National Schizophrenia Fellowship, for helping in the identification of families for the study. We would like to acknowledge the support of the Wellcome Trust, the Stanley Medical Research Institute and the Psychiatry Research Trust.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorZanelli, J
 
dc.contributor.authorMacCabe, J
 
dc.contributor.authorToulopoulou, T
 
dc.contributor.authorWalshe, M
 
dc.contributor.authorMcDonald, C
 
dc.contributor.authorMurray, R
 
dc.date.accessioned2011-09-27T03:02:52Z
 
dc.date.available2011-09-27T03:02:52Z
 
dc.date.issued2009
 
dc.description.abstractImpairments on neuropsychological and eye movement tasks have been demonstrated in schizophrenic patients and also reported in their unaffected relatives. However, it is not clear to what extent these phenotypes overlap. This study examined the relationship between specific eye movement and neuropsychological measures. The relationship between performance on eye movement and neuropsychological tasks was measured in 79 schizophrenic patients (63% from multiply affected families), 129 of their healthy first-degree relatives, and 72 normal controls. Antisaccade scores were correlated with most measures of neurocognitive functioning, and this correlation was strongest in schizophrenic patients in all cases. In the schizophrenic patients, but not their relatives or controls, the antisaccade distractibility error (ADE) score correlated significantly with current intelligence, verbal memory (immediate and delayed recall), and associative learning. In the case of crystallised IQ and delayed verbal memory, smaller correlations were present in unaffected relatives, although neither survived Bonferroni correction. Smooth pursuit performance was unrelated to any neuropsychological measure. Our study suggests that antisaccade errors are likely to represent part of a generalized neuropsychological deficit in schizophrenia. © 2008 Elsevier Ireland Ltd. All rights reserved.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationPsychiatry Research, 2009, v. 168 n. 3, p. 193-197 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.psychres.2008.05.008
 
dc.identifier.citeulike5466317
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.psychres.2008.05.008
 
dc.identifier.epage197
 
dc.identifier.isiWOS:000269118700004
Funding AgencyGrant Number
Wellcome Trust
Stanley Medical Research Institute
Psychiatry Research Trust
Funding Information:

We would like to thank all the families who participated in the study and the Rethink, the National Schizophrenia Fellowship, for helping in the identification of families for the study. We would like to acknowledge the support of the Wellcome Trust, the Stanley Medical Research Institute and the Psychiatry Research Trust.

 
dc.identifier.issn0165-1781
2012 Impact Factor: 2.456
2012 SCImago Journal Rankings: 1.194
 
dc.identifier.issue3
 
dc.identifier.pmid19541370
 
dc.identifier.scopuseid_2-s2.0-67650578592
 
dc.identifier.spage193
 
dc.identifier.urihttp://hdl.handle.net/10722/141834
 
dc.identifier.volume168
 
dc.languageeng
 
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychres
 
dc.publisher.placeIreland
 
dc.relation.ispartofPsychiatry Research
 
dc.relation.referencesReferences in Scopus
 
dc.subjectAntisaccade
 
dc.subjectEye movement
 
dc.subjectNeuropsychology
 
dc.subjectSchizophrenia
 
dc.subjectSmooth pursuit
 
dc.titleNeuropsychological correlates of eye movement abnormalities in schizophrenic patients and their unaffected relatives
 
dc.typeArticle
 
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Author Affiliations
  1. King's College London