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Article: Increased inferior frontal activation during word generation: A marker of genetic risk for schizophrenia but not bipolar disorder?
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TitleIncreased inferior frontal activation during word generation: A marker of genetic risk for schizophrenia but not bipolar disorder?
 
AuthorsCostafreda, SG1
Fu, CHY1
Picchioni, M1
Kane, F1
McDonald, C1
Prata, DP1
Kalidindi, S1
Walshe, M1
Curtis, V1
Bramon, E1
Kravariti, E1
Marshall, N1
Toulopoulou, T1
Barker, GJ1
David, AS1
Brammer, MJ1
Murray, RM1
McGuire, PK1
 
KeywordsBipolar disorder
Functional magnetic resonance imaging
Schizophrenia
Twin study
Verbal fluency
 
Issue Date2009
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751
 
CitationHuman Brain Mapping, 2009, v. 30 n. 10, p. 3287-3298 [How to Cite?]
DOI: http://dx.doi.org/10.1002/hbm.20749
 
AbstractDuring verbal-fluency tasks, impairments in performance and functional abnormalities in the inferior frontal cortex have been observed in both schizophrenia patients and their unaffected relatives. We sought to examine whether such functional abnormalities are a specific marker of genetic vulnerability to schizophrenia. We studied a sample of 132 subjects, comprising 39 patients with schizophrenia, 10 unaffected monozygotic (MZ) cotwins of schizophrenia probands, 28 patients with bipolar disorder, 7 unaffected MZ cotwins of bipolar disorder probands and 48 healthy controls. Blood oxygen level-dependent response was measured using functional magnetic resonance imaging during the performance of an overt verbal-fluency task with two levels of task difficulty, in a cytoarchitectonic region of interest encompassing Brodmann areas 44 and 45 bilaterally. Patients with schizophrenia and the unaffected MZ cotwins of schizophrenia probands showed increased activation in the inferior frontal cortex relative to healthy controls and bipolar patients. Increased engagement of the inferior frontal cortex during verbal-fluency may thus be a marker of genetic vulnerability to schizophrenia. © 2009 Wiley-Liss, Inc.
 
ISSN1065-9471
2012 Impact Factor: 6.878
2012 SCImago Journal Rankings: 3.002
 
DOIhttp://dx.doi.org/10.1002/hbm.20749
 
ISI Accession Number IDWOS:000270853700017
Funding AgencyGrant Number
Medical Research Council of United Kingdom (Neuroinformatics)
Funding Information:

Contract grant sponsor: Medical Research Council of United Kingdom (Neuroinformatics).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorCostafreda, SG
 
dc.contributor.authorFu, CHY
 
dc.contributor.authorPicchioni, M
 
dc.contributor.authorKane, F
 
dc.contributor.authorMcDonald, C
 
dc.contributor.authorPrata, DP
 
dc.contributor.authorKalidindi, S
 
dc.contributor.authorWalshe, M
 
dc.contributor.authorCurtis, V
 
dc.contributor.authorBramon, E
 
dc.contributor.authorKravariti, E
 
dc.contributor.authorMarshall, N
 
dc.contributor.authorToulopoulou, T
 
dc.contributor.authorBarker, GJ
 
dc.contributor.authorDavid, AS
 
dc.contributor.authorBrammer, MJ
 
dc.contributor.authorMurray, RM
 
dc.contributor.authorMcGuire, PK
 
dc.date.accessioned2011-09-27T03:02:52Z
 
dc.date.available2011-09-27T03:02:52Z
 
dc.date.issued2009
 
dc.description.abstractDuring verbal-fluency tasks, impairments in performance and functional abnormalities in the inferior frontal cortex have been observed in both schizophrenia patients and their unaffected relatives. We sought to examine whether such functional abnormalities are a specific marker of genetic vulnerability to schizophrenia. We studied a sample of 132 subjects, comprising 39 patients with schizophrenia, 10 unaffected monozygotic (MZ) cotwins of schizophrenia probands, 28 patients with bipolar disorder, 7 unaffected MZ cotwins of bipolar disorder probands and 48 healthy controls. Blood oxygen level-dependent response was measured using functional magnetic resonance imaging during the performance of an overt verbal-fluency task with two levels of task difficulty, in a cytoarchitectonic region of interest encompassing Brodmann areas 44 and 45 bilaterally. Patients with schizophrenia and the unaffected MZ cotwins of schizophrenia probands showed increased activation in the inferior frontal cortex relative to healthy controls and bipolar patients. Increased engagement of the inferior frontal cortex during verbal-fluency may thus be a marker of genetic vulnerability to schizophrenia. © 2009 Wiley-Liss, Inc.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationHuman Brain Mapping, 2009, v. 30 n. 10, p. 3287-3298 [How to Cite?]
DOI: http://dx.doi.org/10.1002/hbm.20749
 
dc.identifier.doihttp://dx.doi.org/10.1002/hbm.20749
 
dc.identifier.epage3298
 
dc.identifier.isiWOS:000270853700017
Funding AgencyGrant Number
Medical Research Council of United Kingdom (Neuroinformatics)
Funding Information:

Contract grant sponsor: Medical Research Council of United Kingdom (Neuroinformatics).

 
dc.identifier.issn1065-9471
2012 Impact Factor: 6.878
2012 SCImago Journal Rankings: 3.002
 
dc.identifier.issue10
 
dc.identifier.pmid19479729
 
dc.identifier.scopuseid_2-s2.0-70349303493
 
dc.identifier.spage3287
 
dc.identifier.urihttp://hdl.handle.net/10722/141833
 
dc.identifier.volume30
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751
 
dc.publisher.placeUnited States
 
dc.relation.ispartofHuman Brain Mapping
 
dc.relation.referencesReferences in Scopus
 
dc.subjectBipolar disorder
 
dc.subjectFunctional magnetic resonance imaging
 
dc.subjectSchizophrenia
 
dc.subjectTwin study
 
dc.subjectVerbal fluency
 
dc.titleIncreased inferior frontal activation during word generation: A marker of genetic risk for schizophrenia but not bipolar disorder?
 
dc.typeArticle
 
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Author Affiliations
  1. King's College London