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Article: Increased inferior frontal activation during word generation: A marker of genetic risk for schizophrenia but not bipolar disorder?

TitleIncreased inferior frontal activation during word generation: A marker of genetic risk for schizophrenia but not bipolar disorder?
Authors
KeywordsBipolar disorder
Functional magnetic resonance imaging
Schizophrenia
Twin study
Verbal fluency
Issue Date2009
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751
Citation
Human Brain Mapping, 2009, v. 30 n. 10, p. 3287-3298 How to Cite?
AbstractDuring verbal-fluency tasks, impairments in performance and functional abnormalities in the inferior frontal cortex have been observed in both schizophrenia patients and their unaffected relatives. We sought to examine whether such functional abnormalities are a specific marker of genetic vulnerability to schizophrenia. We studied a sample of 132 subjects, comprising 39 patients with schizophrenia, 10 unaffected monozygotic (MZ) cotwins of schizophrenia probands, 28 patients with bipolar disorder, 7 unaffected MZ cotwins of bipolar disorder probands and 48 healthy controls. Blood oxygen level-dependent response was measured using functional magnetic resonance imaging during the performance of an overt verbal-fluency task with two levels of task difficulty, in a cytoarchitectonic region of interest encompassing Brodmann areas 44 and 45 bilaterally. Patients with schizophrenia and the unaffected MZ cotwins of schizophrenia probands showed increased activation in the inferior frontal cortex relative to healthy controls and bipolar patients. Increased engagement of the inferior frontal cortex during verbal-fluency may thus be a marker of genetic vulnerability to schizophrenia. © 2009 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/141833
ISSN
2014 Impact Factor: 5.969
2014 SCImago Journal Rankings: 2.535
ISI Accession Number ID
Funding AgencyGrant Number
Medical Research Council of United Kingdom (Neuroinformatics)
Funding Information:

Contract grant sponsor: Medical Research Council of United Kingdom (Neuroinformatics).

References

 

DC FieldValueLanguage
dc.contributor.authorCostafreda, SGen_HK
dc.contributor.authorFu, CHYen_HK
dc.contributor.authorPicchioni, Men_HK
dc.contributor.authorKane, Fen_HK
dc.contributor.authorMcDonald, Cen_HK
dc.contributor.authorPrata, DPen_HK
dc.contributor.authorKalidindi, Sen_HK
dc.contributor.authorWalshe, Men_HK
dc.contributor.authorCurtis, Ven_HK
dc.contributor.authorBramon, Een_HK
dc.contributor.authorKravariti, Een_HK
dc.contributor.authorMarshall, Nen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorBarker, GJen_HK
dc.contributor.authorDavid, ASen_HK
dc.contributor.authorBrammer, MJen_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorMcGuire, PKen_HK
dc.date.accessioned2011-09-27T03:02:52Z-
dc.date.available2011-09-27T03:02:52Z-
dc.date.issued2009en_HK
dc.identifier.citationHuman Brain Mapping, 2009, v. 30 n. 10, p. 3287-3298en_HK
dc.identifier.issn1065-9471en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141833-
dc.description.abstractDuring verbal-fluency tasks, impairments in performance and functional abnormalities in the inferior frontal cortex have been observed in both schizophrenia patients and their unaffected relatives. We sought to examine whether such functional abnormalities are a specific marker of genetic vulnerability to schizophrenia. We studied a sample of 132 subjects, comprising 39 patients with schizophrenia, 10 unaffected monozygotic (MZ) cotwins of schizophrenia probands, 28 patients with bipolar disorder, 7 unaffected MZ cotwins of bipolar disorder probands and 48 healthy controls. Blood oxygen level-dependent response was measured using functional magnetic resonance imaging during the performance of an overt verbal-fluency task with two levels of task difficulty, in a cytoarchitectonic region of interest encompassing Brodmann areas 44 and 45 bilaterally. Patients with schizophrenia and the unaffected MZ cotwins of schizophrenia probands showed increased activation in the inferior frontal cortex relative to healthy controls and bipolar patients. Increased engagement of the inferior frontal cortex during verbal-fluency may thus be a marker of genetic vulnerability to schizophrenia. © 2009 Wiley-Liss, Inc.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751en_HK
dc.relation.ispartofHuman Brain Mappingen_HK
dc.subjectBipolar disorderen_HK
dc.subjectFunctional magnetic resonance imagingen_HK
dc.subjectSchizophreniaen_HK
dc.subjectTwin studyen_HK
dc.subjectVerbal fluencyen_HK
dc.titleIncreased inferior frontal activation during word generation: A marker of genetic risk for schizophrenia but not bipolar disorder?en_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/hbm.20749en_HK
dc.identifier.pmid19479729-
dc.identifier.scopuseid_2-s2.0-70349303493en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70349303493&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume30en_HK
dc.identifier.issue10en_HK
dc.identifier.spage3287en_HK
dc.identifier.epage3298en_HK
dc.identifier.isiWOS:000270853700017-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCostafreda, SG=8916108100en_HK
dc.identifier.scopusauthoridFu, CHY=8502155300en_HK
dc.identifier.scopusauthoridPicchioni, M=6507443795en_HK
dc.identifier.scopusauthoridKane, F=24829114900en_HK
dc.identifier.scopusauthoridMcDonald, C=8749594800en_HK
dc.identifier.scopusauthoridPrata, DP=14632352500en_HK
dc.identifier.scopusauthoridKalidindi, S=24366595400en_HK
dc.identifier.scopusauthoridWalshe, M=8855469300en_HK
dc.identifier.scopusauthoridCurtis, V=7003382545en_HK
dc.identifier.scopusauthoridBramon, E=8089378900en_HK
dc.identifier.scopusauthoridKravariti, E=8855469000en_HK
dc.identifier.scopusauthoridMarshall, N=7102431159en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridBarker, GJ=34869208000en_HK
dc.identifier.scopusauthoridDavid, AS=7402606754en_HK
dc.identifier.scopusauthoridBrammer, MJ=7006746119en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridMcGuire, PK=7101880438en_HK

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