Article: Increased inferior frontal activation during word generation: A marker of genetic risk for schizophrenia but not bipolar disorder?

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TitleIncreased inferior frontal activation during word generation: A marker of genetic risk for schizophrenia but not bipolar disorder?
AuthorsCostafreda, SG1
Fu, CHY1
Picchioni, M1
Kane, F1
McDonald, C1
Prata, DP1
Kalidindi, S1
Walshe, M1
Curtis, V1
Bramon, E1
Kravariti, E1
Marshall, N1
Toulopoulou, T1
Barker, GJ1
David, AS1
Brammer, MJ1
Murray, RM1
McGuire, PK1
KeywordsBipolar disorder
Functional magnetic resonance imaging
Schizophrenia
Twin study
Verbal fluency
Issue Date2009
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751
CitationHuman Brain Mapping, 2009, v. 30 n. 10, p. 3287-3298 [How to Cite?]
DOI: http://dx.doi.org/10.1002/hbm.20749
AbstractDuring verbal-fluency tasks, impairments in performance and functional abnormalities in the inferior frontal cortex have been observed in both schizophrenia patients and their unaffected relatives. We sought to examine whether such functional abnormalities are a specific marker of genetic vulnerability to schizophrenia. We studied a sample of 132 subjects, comprising 39 patients with schizophrenia, 10 unaffected monozygotic (MZ) cotwins of schizophrenia probands, 28 patients with bipolar disorder, 7 unaffected MZ cotwins of bipolar disorder probands and 48 healthy controls. Blood oxygen level-dependent response was measured using functional magnetic resonance imaging during the performance of an overt verbal-fluency task with two levels of task difficulty, in a cytoarchitectonic region of interest encompassing Brodmann areas 44 and 45 bilaterally. Patients with schizophrenia and the unaffected MZ cotwins of schizophrenia probands showed increased activation in the inferior frontal cortex relative to healthy controls and bipolar patients. Increased engagement of the inferior frontal cortex during verbal-fluency may thus be a marker of genetic vulnerability to schizophrenia. © 2009 Wiley-Liss, Inc.
ISSN1065-9471
2011 Impact Factor: 5.88
2011 SCImago Journal Rankings: 0.416
DOIhttp://dx.doi.org/10.1002/hbm.20749
ISI Accession Number IDWOS:000270853700017
Funding AgencyGrant Number
Medical Research Council of United Kingdom (Neuroinformatics)
Funding Information:

Contract grant sponsor: Medical Research Council of United Kingdom (Neuroinformatics).

ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorCostafreda, SG
dc.contributor.authorFu, CHY
dc.contributor.authorPicchioni, M
dc.contributor.authorKane, F
dc.contributor.authorMcDonald, C
dc.contributor.authorPrata, DP
dc.contributor.authorKalidindi, S
dc.contributor.authorWalshe, M
dc.contributor.authorCurtis, V
dc.contributor.authorBramon, E
dc.contributor.authorKravariti, E
dc.contributor.authorMarshall, N
dc.contributor.authorToulopoulou, T
dc.contributor.authorBarker, GJ
dc.contributor.authorDavid, AS
dc.contributor.authorBrammer, MJ
dc.contributor.authorMurray, RM
dc.contributor.authorMcGuire, PK
dc.date.accessioned2011-09-27T03:02:52Z
dc.date.available2011-09-27T03:02:52Z
dc.date.issued2009
dc.description.abstractDuring verbal-fluency tasks, impairments in performance and functional abnormalities in the inferior frontal cortex have been observed in both schizophrenia patients and their unaffected relatives. We sought to examine whether such functional abnormalities are a specific marker of genetic vulnerability to schizophrenia. We studied a sample of 132 subjects, comprising 39 patients with schizophrenia, 10 unaffected monozygotic (MZ) cotwins of schizophrenia probands, 28 patients with bipolar disorder, 7 unaffected MZ cotwins of bipolar disorder probands and 48 healthy controls. Blood oxygen level-dependent response was measured using functional magnetic resonance imaging during the performance of an overt verbal-fluency task with two levels of task difficulty, in a cytoarchitectonic region of interest encompassing Brodmann areas 44 and 45 bilaterally. Patients with schizophrenia and the unaffected MZ cotwins of schizophrenia probands showed increased activation in the inferior frontal cortex relative to healthy controls and bipolar patients. Increased engagement of the inferior frontal cortex during verbal-fluency may thus be a marker of genetic vulnerability to schizophrenia. © 2009 Wiley-Liss, Inc.
dc.description.naturelink_to_subscribed_fulltext
dc.identifier.citationHuman Brain Mapping, 2009, v. 30 n. 10, p. 3287-3298 [How to Cite?]
DOI: http://dx.doi.org/10.1002/hbm.20749
dc.identifier.doihttp://dx.doi.org/10.1002/hbm.20749
dc.identifier.epage3298
dc.identifier.isiWOS:000270853700017
Funding AgencyGrant Number
Medical Research Council of United Kingdom (Neuroinformatics)
Funding Information:

Contract grant sponsor: Medical Research Council of United Kingdom (Neuroinformatics).

dc.identifier.issn1065-9471
2011 Impact Factor: 5.88
2011 SCImago Journal Rankings: 0.416
dc.identifier.issue10
dc.identifier.pmid19479729
dc.identifier.scopuseid_2-s2.0-70349303493
dc.identifier.spage3287
dc.identifier.urihttp://hdl.handle.net/10722/141833
dc.identifier.volume30
dc.languageeng
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751
dc.publisher.placeUnited States
dc.relation.ispartofHuman Brain Mapping
dc.relation.referencesReferences in Scopus
dc.subjectBipolar disorder
dc.subjectFunctional magnetic resonance imaging
dc.subjectSchizophrenia
dc.subjectTwin study
dc.subjectVerbal fluency
dc.titleIncreased inferior frontal activation during word generation: A marker of genetic risk for schizophrenia but not bipolar disorder?
dc.typeArticle
Author Affiliations
  1. King's College London