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Article: Regional Gray Matter Volume in Monozygotic Twins Concordant and Discordant for Schizophrenia

TitleRegional Gray Matter Volume in Monozygotic Twins Concordant and Discordant for Schizophrenia
Authors
KeywordsConcordant
discordant
MRI
schizophrenia
twin
voxel-based morphometry
Issue Date2010
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiat
Citation
Biological Psychiatry, 2010, v. 67 n. 10, p. 956-964 How to Cite?
AbstractBackground: Alterations in gray matter volume (GMV) are a robust feature of schizophrenia. However, it is not clear to what extent these abnormalities are correlates of the genetic liability to the disorder, as opposed to environmental factors and the disorder itself. We investigated the influence of genetic and environmental risk on GMV in monozygotic (MZ) twin pairs concordant and discordant for schizophrenia. Methods: Total and regional GMVs were measured from magnetic resonance images of 80 twins: 14 MZ pairs concordant for schizophrenia, 9 pairs discordant for schizophrenia, and 17 healthy MZ twin pairs. Results: Total GMV was smaller in twins with schizophrenia (t = -3.17, p = .003) and nonpsychotic cotwins from discordant pairs (t = -2.66, p = .011) than in healthy control twins. Twin pairs concordant for schizophrenia displayed reduced regional GMV in the inferior frontal, medial frontal, and anterior cingulate gyri; the caudate; lingual gyrus; and cerebellum relative to healthy twins (p < .05, corrected). Within discordant pairs, twins with schizophrenia had less GMV than their nonpsychotic cotwins in the insula; superior/medial frontal, pre/postcentral, cingulate, and superior temporal gyri; and the paracentral lobule. There were no significant differences in regional GMV between nonpsychotic cotwins and healthy control subjects. Conclusions: The presence of schizophrenia was specifically related to reduced GMV in frontal, insular, cingulate, medial parietal, and temporal cortex, over and above effects of genetic risk for the disorder. These changes could be related to the pathophysiology of the disorder itself or to unique environmental factors acting etiologically or because of the illness. © 2010 Society of Biological Psychiatry.
Persistent Identifierhttp://hdl.handle.net/10722/141831
ISSN
2015 Impact Factor: 11.212
2015 SCImago Journal Rankings: 5.823
ISI Accession Number ID
Funding AgencyGrant Number
Wellcome Trust064971
Psychiatry Research Trust
Swiss National Science FoundationPBBSB-106936
3232BO-119382
Funding Information:

This study was supported by Grant 064971 from the Wellcome Trust, whereas the costs of acquiring the scans was supported by the Psychiatry Research Trust. The author was supported by personal grants (Number PBBSB-106936, 3232BO-119382) from the Swiss National Science Foundation. The author UE is supported by the Deutsche Forschungsgemeinschaft (ET 31/2-1). The funding sources of the study had no role in the design or conduct of the study: collection, management. analysis, or interpretation of the data: or preparation, review, or approval of the manuscript.

References

 

DC FieldValueLanguage
dc.contributor.authorBorgwardt, SJen_HK
dc.contributor.authorPicchioni, MMen_HK
dc.contributor.authorEttinger, Uen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorMurray, Ren_HK
dc.contributor.authorMcGuire, PKen_HK
dc.date.accessioned2011-09-27T03:02:50Z-
dc.date.available2011-09-27T03:02:50Z-
dc.date.issued2010en_HK
dc.identifier.citationBiological Psychiatry, 2010, v. 67 n. 10, p. 956-964en_HK
dc.identifier.issn0006-3223en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141831-
dc.description.abstractBackground: Alterations in gray matter volume (GMV) are a robust feature of schizophrenia. However, it is not clear to what extent these abnormalities are correlates of the genetic liability to the disorder, as opposed to environmental factors and the disorder itself. We investigated the influence of genetic and environmental risk on GMV in monozygotic (MZ) twin pairs concordant and discordant for schizophrenia. Methods: Total and regional GMVs were measured from magnetic resonance images of 80 twins: 14 MZ pairs concordant for schizophrenia, 9 pairs discordant for schizophrenia, and 17 healthy MZ twin pairs. Results: Total GMV was smaller in twins with schizophrenia (t = -3.17, p = .003) and nonpsychotic cotwins from discordant pairs (t = -2.66, p = .011) than in healthy control twins. Twin pairs concordant for schizophrenia displayed reduced regional GMV in the inferior frontal, medial frontal, and anterior cingulate gyri; the caudate; lingual gyrus; and cerebellum relative to healthy twins (p < .05, corrected). Within discordant pairs, twins with schizophrenia had less GMV than their nonpsychotic cotwins in the insula; superior/medial frontal, pre/postcentral, cingulate, and superior temporal gyri; and the paracentral lobule. There were no significant differences in regional GMV between nonpsychotic cotwins and healthy control subjects. Conclusions: The presence of schizophrenia was specifically related to reduced GMV in frontal, insular, cingulate, medial parietal, and temporal cortex, over and above effects of genetic risk for the disorder. These changes could be related to the pathophysiology of the disorder itself or to unique environmental factors acting etiologically or because of the illness. © 2010 Society of Biological Psychiatry.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiaten_HK
dc.relation.ispartofBiological Psychiatryen_HK
dc.subjectConcordanten_HK
dc.subjectdiscordanten_HK
dc.subjectMRIen_HK
dc.subjectschizophreniaen_HK
dc.subjecttwinen_HK
dc.subjectvoxel-based morphometryen_HK
dc.titleRegional Gray Matter Volume in Monozygotic Twins Concordant and Discordant for Schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.biopsych.2009.10.026en_HK
dc.identifier.pmid20006324-
dc.identifier.scopuseid_2-s2.0-77951622060en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77951622060&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume67en_HK
dc.identifier.issue10en_HK
dc.identifier.spage956en_HK
dc.identifier.epage964en_HK
dc.identifier.isiWOS:000277629900009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridBorgwardt, SJ=12240845100en_HK
dc.identifier.scopusauthoridPicchioni, MM=6507443795en_HK
dc.identifier.scopusauthoridEttinger, U=6602766172en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridMurray, R=35406239400en_HK
dc.identifier.scopusauthoridMcGuire, PK=7101880438en_HK
dc.identifier.citeulike6411470-

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