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Article: Genetic modelling of childhood social development and personality in twins and siblings with schizophrenia
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TitleGenetic modelling of childhood social development and personality in twins and siblings with schizophrenia
 
AuthorsPicchioni, MM1 1
Walshe, M1
Toulopoulou, T1
McDonald, C3
Taylor, M2
WatersMetenier, S1
Bramon, E1
Regojo, A1
Murray, RM1
Rijsdijk, F
 
KeywordsGenes
personality
schizophrenia
social development
twins
 
Issue Date2010
 
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
 
CitationPsychological Medicine, 2010, v. 40 n. 8, p. 1305-1316 [How to Cite?]
DOI: http://dx.doi.org/10.1017/S0033291709991425
 
AbstractBackground Abnormalities in early social development and personality are present in patients with schizophrenia and their unaffected relatives. This study aimed to establish the degree to which these childhood and adolescent developmental abnormalities are genetically determined.Method We used a combined twin and family study design (n=531) to assess childhood and adolescent social adjustment and schizotypal personality traits in 98 twin pairs (n=196) varying in their zygosity and concordance for schizophrenia and 156 sibling clusters (n=335) varying in their concordance for schizophrenia.Results Schizophrenia was significantly associated with childhood and adolescent deficits in social adjustment and personality, with additive genetic effects being the main source of these phenotypic correlations.Conclusions Abnormalities of social adjustment and personality are present in children and adolescents who later develop schizophrenia, reflecting the influence of common genetic risk. © Cambridge University Press 2009.
 
ISSN0033-2917
2012 Impact Factor: 5.587
2012 SCImago Journal Rankings: 2.581
 
DOIhttp://dx.doi.org/10.1017/S0033291709991425
 
ISI Accession Number IDWOS:000280158500008
Funding AgencyGrant Number
Wellcome Trust064971
NARSAD
Stanley Medical Research Institute
Funding Information:

We acknowledge the financial support of the Wellcome Trust, Research Training Fellowship (064971) to M.M.P., the NARSAD Young Investigator Award to T. T., and the Stanley Medical Research Institute.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorPicchioni, MM
 
dc.contributor.authorWalshe, M
 
dc.contributor.authorToulopoulou, T
 
dc.contributor.authorMcDonald, C
 
dc.contributor.authorTaylor, M
 
dc.contributor.authorWatersMetenier, S
 
dc.contributor.authorBramon, E
 
dc.contributor.authorRegojo, A
 
dc.contributor.authorMurray, RM
 
dc.contributor.authorRijsdijk, F
 
dc.date.accessioned2011-09-27T03:02:50Z
 
dc.date.available2011-09-27T03:02:50Z
 
dc.date.issued2010
 
dc.description.abstractBackground Abnormalities in early social development and personality are present in patients with schizophrenia and their unaffected relatives. This study aimed to establish the degree to which these childhood and adolescent developmental abnormalities are genetically determined.Method We used a combined twin and family study design (n=531) to assess childhood and adolescent social adjustment and schizotypal personality traits in 98 twin pairs (n=196) varying in their zygosity and concordance for schizophrenia and 156 sibling clusters (n=335) varying in their concordance for schizophrenia.Results Schizophrenia was significantly associated with childhood and adolescent deficits in social adjustment and personality, with additive genetic effects being the main source of these phenotypic correlations.Conclusions Abnormalities of social adjustment and personality are present in children and adolescents who later develop schizophrenia, reflecting the influence of common genetic risk. © Cambridge University Press 2009.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationPsychological Medicine, 2010, v. 40 n. 8, p. 1305-1316 [How to Cite?]
DOI: http://dx.doi.org/10.1017/S0033291709991425
 
dc.identifier.doihttp://dx.doi.org/10.1017/S0033291709991425
 
dc.identifier.eissn1469-8978
 
dc.identifier.epage1316
 
dc.identifier.isiWOS:000280158500008
Funding AgencyGrant Number
Wellcome Trust064971
NARSAD
Stanley Medical Research Institute
Funding Information:

We acknowledge the financial support of the Wellcome Trust, Research Training Fellowship (064971) to M.M.P., the NARSAD Young Investigator Award to T. T., and the Stanley Medical Research Institute.

 
dc.identifier.issn0033-2917
2012 Impact Factor: 5.587
2012 SCImago Journal Rankings: 2.581
 
dc.identifier.issue8
 
dc.identifier.scopuseid_2-s2.0-77957155838
 
dc.identifier.spage1305
 
dc.identifier.urihttp://hdl.handle.net/10722/141830
 
dc.identifier.volume40
 
dc.languageeng
 
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofPsychological Medicine
 
dc.relation.referencesReferences in Scopus
 
dc.subjectGenes
 
dc.subjectpersonality
 
dc.subjectschizophrenia
 
dc.subjectsocial development
 
dc.subjecttwins
 
dc.titleGenetic modelling of childhood social development and personality in twins and siblings with schizophrenia
 
dc.typeArticle
 
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<contributor.author>Walshe, M</contributor.author>
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<contributor.author>McDonald, C</contributor.author>
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<contributor.author>WatersMetenier, S</contributor.author>
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Author Affiliations
  1. King's College London
  2. Ballenden House
  3. National University of Ireland Galway