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Article: Genetic modelling of childhood social development and personality in twins and siblings with schizophrenia

TitleGenetic modelling of childhood social development and personality in twins and siblings with schizophrenia
Authors
KeywordsGenes
personality
schizophrenia
social development
twins
Issue Date2010
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
Citation
Psychological Medicine, 2010, v. 40 n. 8, p. 1305-1316 How to Cite?
Abstract
Background Abnormalities in early social development and personality are present in patients with schizophrenia and their unaffected relatives. This study aimed to establish the degree to which these childhood and adolescent developmental abnormalities are genetically determined.Method We used a combined twin and family study design (n=531) to assess childhood and adolescent social adjustment and schizotypal personality traits in 98 twin pairs (n=196) varying in their zygosity and concordance for schizophrenia and 156 sibling clusters (n=335) varying in their concordance for schizophrenia.Results Schizophrenia was significantly associated with childhood and adolescent deficits in social adjustment and personality, with additive genetic effects being the main source of these phenotypic correlations.Conclusions Abnormalities of social adjustment and personality are present in children and adolescents who later develop schizophrenia, reflecting the influence of common genetic risk. © Cambridge University Press 2009.
Persistent Identifierhttp://hdl.handle.net/10722/141830
ISSN
2013 Impact Factor: 5.428
ISI Accession Number ID
Funding AgencyGrant Number
Wellcome Trust064971
NARSAD
Stanley Medical Research Institute
Funding Information:

We acknowledge the financial support of the Wellcome Trust, Research Training Fellowship (064971) to M.M.P., the NARSAD Young Investigator Award to T. T., and the Stanley Medical Research Institute.

References

 

Author Affiliations
  1. King's College London
  2. Ballenden House
  3. National University of Ireland Galway
DC FieldValueLanguage
dc.contributor.authorPicchioni, MMen_HK
dc.contributor.authorWalshe, Men_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorMcDonald, Cen_HK
dc.contributor.authorTaylor, Men_HK
dc.contributor.authorWatersMetenier, Sen_HK
dc.contributor.authorBramon, Een_HK
dc.contributor.authorRegojo, Aen_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorRijsdijk, Fen_HK
dc.date.accessioned2011-09-27T03:02:50Z-
dc.date.available2011-09-27T03:02:50Z-
dc.date.issued2010en_HK
dc.identifier.citationPsychological Medicine, 2010, v. 40 n. 8, p. 1305-1316en_HK
dc.identifier.issn0033-2917en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141830-
dc.description.abstractBackground Abnormalities in early social development and personality are present in patients with schizophrenia and their unaffected relatives. This study aimed to establish the degree to which these childhood and adolescent developmental abnormalities are genetically determined.Method We used a combined twin and family study design (n=531) to assess childhood and adolescent social adjustment and schizotypal personality traits in 98 twin pairs (n=196) varying in their zygosity and concordance for schizophrenia and 156 sibling clusters (n=335) varying in their concordance for schizophrenia.Results Schizophrenia was significantly associated with childhood and adolescent deficits in social adjustment and personality, with additive genetic effects being the main source of these phenotypic correlations.Conclusions Abnormalities of social adjustment and personality are present in children and adolescents who later develop schizophrenia, reflecting the influence of common genetic risk. © Cambridge University Press 2009.en_HK
dc.languageengen_US
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSMen_HK
dc.relation.ispartofPsychological Medicineen_HK
dc.subjectGenesen_HK
dc.subjectpersonalityen_HK
dc.subjectschizophreniaen_HK
dc.subjectsocial developmenten_HK
dc.subjecttwinsen_HK
dc.titleGenetic modelling of childhood social development and personality in twins and siblings with schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1017/S0033291709991425en_HK
dc.identifier.pmid19863839-
dc.identifier.scopuseid_2-s2.0-77957155838en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77957155838&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume40en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1305en_HK
dc.identifier.epage1316en_HK
dc.identifier.eissn1469-8978-
dc.identifier.isiWOS:000280158500008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridPicchioni, MM=6507443795en_HK
dc.identifier.scopusauthoridWalshe, M=8855469300en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridMcDonald, C=8749594800en_HK
dc.identifier.scopusauthoridTaylor, M=8731398500en_HK
dc.identifier.scopusauthoridWatersMetenier, S=36550861500en_HK
dc.identifier.scopusauthoridBramon, E=8089378900en_HK
dc.identifier.scopusauthoridRegojo, A=36550619400en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridRijsdijk, F=6701830835en_HK

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