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Article: Evidence of association of KIBRA genotype with episodic memory in families of psychotic patients and controls
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TitleEvidence of association of KIBRA genotype with episodic memory in families of psychotic patients and controls
 
AuthorsVassos, E2 3
Bramon, E2
Picchioni, M2
Walshe, M2
Filbey, FM2 1
Kravariti, E2
McDonald, C2 4
Murray, RM2
Collier, DA3
Toulopoulou, T2
 
KeywordsEndophenotype
Genetic association
KIBRA gene
Memory
Polymorphism
Schizophrenia
 
Issue Date2010
 
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/jpsychires
 
CitationJournal Of Psychiatric Research, 2010, v. 44 n. 12, p. 795-798 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jpsychires.2010.01.012
 
AbstractThe first genome-wide association study of human memory identified an association between a common T/C polymorphism of the KIBRA gene (rs17070145) and episodic memory performance in normal individuals; subsequent studies have implicated the same polymorphism in Alzheimer's disease. Since impaired neurocognitive performance, including memory, may be both a core feature of schizophrenia and a candidate endophenotype, we attempted to replicate this association in a total sample of 544 subjects (including patients with psychosis, their unaffected relatives as well as normal individuals). In the combined sample there was a significant association between the KIBRA T allele and better performance in the single principle component of the memory measures, which included immediate and delayed logical and visual memory from the Wechsler Memory Scale (p=0.019). In the unaffected individuals (patients' relatives and healthy controls) we observed an association of KIBRA with immediate and delayed logical memory (p=0.020 and 0.025, respectively), while in patients with psychosis with delayed visual memory (p=0.05). This study replicates the association between the KIBRA gene and episodic memory and suggests a possibly differential effect of the polymorphism in psychotic and non-psychotic individuals. © 2010 Elsevier Ltd.
 
ISSN0022-3956
2012 Impact Factor: 4.066
2012 SCImago Journal Rankings: 1.885
 
DOIhttp://dx.doi.org/10.1016/j.jpsychires.2010.01.012
 
ISI Accession Number IDWOS:000281330100009
Funding AgencyGrant Number
NARSAD
Scholarship Foundation of Greece
Department of Health
Wellcome Trust064971
Funding Information:

EV was supported by a NARSAD Young Investigator Award and a grant from the State Scholarship Foundation of Greece. EB was supported by the Department of Health and a NARSAD YIA. MP was supported by a Wellcome Trust Research Training Fellowship 064971. The above funding agencies played no active role in the research reported in this manuscript.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorVassos, E
 
dc.contributor.authorBramon, E
 
dc.contributor.authorPicchioni, M
 
dc.contributor.authorWalshe, M
 
dc.contributor.authorFilbey, FM
 
dc.contributor.authorKravariti, E
 
dc.contributor.authorMcDonald, C
 
dc.contributor.authorMurray, RM
 
dc.contributor.authorCollier, DA
 
dc.contributor.authorToulopoulou, T
 
dc.date.accessioned2011-09-27T03:02:46Z
 
dc.date.available2011-09-27T03:02:46Z
 
dc.date.issued2010
 
dc.description.abstractThe first genome-wide association study of human memory identified an association between a common T/C polymorphism of the KIBRA gene (rs17070145) and episodic memory performance in normal individuals; subsequent studies have implicated the same polymorphism in Alzheimer's disease. Since impaired neurocognitive performance, including memory, may be both a core feature of schizophrenia and a candidate endophenotype, we attempted to replicate this association in a total sample of 544 subjects (including patients with psychosis, their unaffected relatives as well as normal individuals). In the combined sample there was a significant association between the KIBRA T allele and better performance in the single principle component of the memory measures, which included immediate and delayed logical and visual memory from the Wechsler Memory Scale (p=0.019). In the unaffected individuals (patients' relatives and healthy controls) we observed an association of KIBRA with immediate and delayed logical memory (p=0.020 and 0.025, respectively), while in patients with psychosis with delayed visual memory (p=0.05). This study replicates the association between the KIBRA gene and episodic memory and suggests a possibly differential effect of the polymorphism in psychotic and non-psychotic individuals. © 2010 Elsevier Ltd.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Psychiatric Research, 2010, v. 44 n. 12, p. 795-798 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jpsychires.2010.01.012
 
dc.identifier.citeulike6796900
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.jpsychires.2010.01.012
 
dc.identifier.epage798
 
dc.identifier.isiWOS:000281330100009
Funding AgencyGrant Number
NARSAD
Scholarship Foundation of Greece
Department of Health
Wellcome Trust064971
Funding Information:

EV was supported by a NARSAD Young Investigator Award and a grant from the State Scholarship Foundation of Greece. EB was supported by the Department of Health and a NARSAD YIA. MP was supported by a Wellcome Trust Research Training Fellowship 064971. The above funding agencies played no active role in the research reported in this manuscript.

 
dc.identifier.issn0022-3956
2012 Impact Factor: 4.066
2012 SCImago Journal Rankings: 1.885
 
dc.identifier.issue12
 
dc.identifier.pmid20185150
 
dc.identifier.scopuseid_2-s2.0-77955429862
 
dc.identifier.spage795
 
dc.identifier.urihttp://hdl.handle.net/10722/141828
 
dc.identifier.volume44
 
dc.languageeng
 
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/jpsychires
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofJournal of Psychiatric Research
 
dc.relation.referencesReferences in Scopus
 
dc.subjectEndophenotype
 
dc.subjectGenetic association
 
dc.subjectKIBRA gene
 
dc.subjectMemory
 
dc.subjectPolymorphism
 
dc.subjectSchizophrenia
 
dc.titleEvidence of association of KIBRA genotype with episodic memory in families of psychotic patients and controls
 
dc.typeArticle
 
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<contributor.author>Filbey, FM</contributor.author>
<contributor.author>Kravariti, E</contributor.author>
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Author Affiliations
  1. The Mind Research Network
  2. King's College London
  3. Medical Research Council
  4. National University of Ireland Galway