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Article: Evidence of association of KIBRA genotype with episodic memory in families of psychotic patients and controls

TitleEvidence of association of KIBRA genotype with episodic memory in families of psychotic patients and controls
Authors
KeywordsEndophenotype
Genetic association
KIBRA gene
Memory
Polymorphism
Schizophrenia
Issue Date2010
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/jpsychires
Citation
Journal Of Psychiatric Research, 2010, v. 44 n. 12, p. 795-798 How to Cite?
AbstractThe first genome-wide association study of human memory identified an association between a common T/C polymorphism of the KIBRA gene (rs17070145) and episodic memory performance in normal individuals; subsequent studies have implicated the same polymorphism in Alzheimer's disease. Since impaired neurocognitive performance, including memory, may be both a core feature of schizophrenia and a candidate endophenotype, we attempted to replicate this association in a total sample of 544 subjects (including patients with psychosis, their unaffected relatives as well as normal individuals). In the combined sample there was a significant association between the KIBRA T allele and better performance in the single principle component of the memory measures, which included immediate and delayed logical and visual memory from the Wechsler Memory Scale (p=0.019). In the unaffected individuals (patients' relatives and healthy controls) we observed an association of KIBRA with immediate and delayed logical memory (p=0.020 and 0.025, respectively), while in patients with psychosis with delayed visual memory (p=0.05). This study replicates the association between the KIBRA gene and episodic memory and suggests a possibly differential effect of the polymorphism in psychotic and non-psychotic individuals. © 2010 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/141828
ISSN
2015 Impact Factor: 4.465
2015 SCImago Journal Rankings: 2.265
ISI Accession Number ID
Funding AgencyGrant Number
NARSAD
Scholarship Foundation of Greece
Department of Health
Wellcome Trust064971
Funding Information:

EV was supported by a NARSAD Young Investigator Award and a grant from the State Scholarship Foundation of Greece. EB was supported by the Department of Health and a NARSAD YIA. MP was supported by a Wellcome Trust Research Training Fellowship 064971. The above funding agencies played no active role in the research reported in this manuscript.

References

 

DC FieldValueLanguage
dc.contributor.authorVassos, Een_HK
dc.contributor.authorBramon, Een_HK
dc.contributor.authorPicchioni, Men_HK
dc.contributor.authorWalshe, Men_HK
dc.contributor.authorFilbey, FMen_HK
dc.contributor.authorKravariti, Een_HK
dc.contributor.authorMcDonald, Cen_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorCollier, DAen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.date.accessioned2011-09-27T03:02:46Z-
dc.date.available2011-09-27T03:02:46Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Psychiatric Research, 2010, v. 44 n. 12, p. 795-798en_HK
dc.identifier.issn0022-3956en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141828-
dc.description.abstractThe first genome-wide association study of human memory identified an association between a common T/C polymorphism of the KIBRA gene (rs17070145) and episodic memory performance in normal individuals; subsequent studies have implicated the same polymorphism in Alzheimer's disease. Since impaired neurocognitive performance, including memory, may be both a core feature of schizophrenia and a candidate endophenotype, we attempted to replicate this association in a total sample of 544 subjects (including patients with psychosis, their unaffected relatives as well as normal individuals). In the combined sample there was a significant association between the KIBRA T allele and better performance in the single principle component of the memory measures, which included immediate and delayed logical and visual memory from the Wechsler Memory Scale (p=0.019). In the unaffected individuals (patients' relatives and healthy controls) we observed an association of KIBRA with immediate and delayed logical memory (p=0.020 and 0.025, respectively), while in patients with psychosis with delayed visual memory (p=0.05). This study replicates the association between the KIBRA gene and episodic memory and suggests a possibly differential effect of the polymorphism in psychotic and non-psychotic individuals. © 2010 Elsevier Ltd.en_HK
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/jpsychiresen_HK
dc.relation.ispartofJournal of Psychiatric Researchen_HK
dc.subjectEndophenotypeen_HK
dc.subjectGenetic associationen_HK
dc.subjectKIBRA geneen_HK
dc.subjectMemoryen_HK
dc.subjectPolymorphismen_HK
dc.subjectSchizophreniaen_HK
dc.titleEvidence of association of KIBRA genotype with episodic memory in families of psychotic patients and controlsen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.jpsychires.2010.01.012en_HK
dc.identifier.pmid20185150-
dc.identifier.scopuseid_2-s2.0-77955429862en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955429862&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume44en_HK
dc.identifier.issue12en_HK
dc.identifier.spage795en_HK
dc.identifier.epage798en_HK
dc.identifier.isiWOS:000281330100009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridVassos, E=35369293900en_HK
dc.identifier.scopusauthoridBramon, E=8089378900en_HK
dc.identifier.scopusauthoridPicchioni, M=6507443795en_HK
dc.identifier.scopusauthoridWalshe, M=8855469300en_HK
dc.identifier.scopusauthoridFilbey, FM=13606061900en_HK
dc.identifier.scopusauthoridKravariti, E=8855469000en_HK
dc.identifier.scopusauthoridMcDonald, C=8749594800en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridCollier, DA=26642980600en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.citeulike6796900-

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