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Article: Qualifying brain functional MRI parameters as endophenotypes in schizophrenia

TitleQualifying brain functional MRI parameters as endophenotypes in schizophrenia
Authors
Keywordsendophenotype
family
fMRI
functional neuroimaging
heritability
relatives
schizophrenia
twins
Issue Date2010
PublisherFuture Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/fnl
Citation
Future Neurology, 2010, v. 5 n. 6, p. 817-838 How to Cite?
AbstractAlthough the genetic contribution to schizophrenia pathogenesis has been well established, with an approximate heritability of 81%, the endeavor to elucidate the complex genetic architecture of schizophrenia has met limited success. 'Endophenotypes, or 'intermediate phenotypes, are more restricted constructs of genetic risk than the clinical manifestations hitherto employed by molecular geneticists. They are, putatively, intermediate in the pathophysiological pathway between genetic variation and clinical phenomenology and can possibly be used to assist in the elucidation of genetic diathesis for schizophrenia. In this article, we present the current evidence that supports functional MRI parameters as promising candidate endophenotypes in schizophrenia. © 2010 Future Medicine Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/141827
ISSN
2015 SCImago Journal Rankings: 0.510
References

 

DC FieldValueLanguage
dc.contributor.authorWatersMetenier, SLen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.date.accessioned2011-09-27T03:02:45Z-
dc.date.available2011-09-27T03:02:45Z-
dc.date.issued2010en_HK
dc.identifier.citationFuture Neurology, 2010, v. 5 n. 6, p. 817-838en_HK
dc.identifier.issn1479-6708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141827-
dc.description.abstractAlthough the genetic contribution to schizophrenia pathogenesis has been well established, with an approximate heritability of 81%, the endeavor to elucidate the complex genetic architecture of schizophrenia has met limited success. 'Endophenotypes, or 'intermediate phenotypes, are more restricted constructs of genetic risk than the clinical manifestations hitherto employed by molecular geneticists. They are, putatively, intermediate in the pathophysiological pathway between genetic variation and clinical phenomenology and can possibly be used to assist in the elucidation of genetic diathesis for schizophrenia. In this article, we present the current evidence that supports functional MRI parameters as promising candidate endophenotypes in schizophrenia. © 2010 Future Medicine Ltd.en_HK
dc.languageengen_US
dc.publisherFuture Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/fnlen_HK
dc.relation.ispartofFuture Neurologyen_HK
dc.subjectendophenotypeen_HK
dc.subjectfamilyen_HK
dc.subjectfMRIen_HK
dc.subjectfunctional neuroimagingen_HK
dc.subjectheritabilityen_HK
dc.subjectrelativesen_HK
dc.subjectschizophreniaen_HK
dc.subjecttwinsen_HK
dc.titleQualifying brain functional MRI parameters as endophenotypes in schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.2217/fnl.10.68en_HK
dc.identifier.scopuseid_2-s2.0-78650256264en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78650256264&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue6en_HK
dc.identifier.spage817en_HK
dc.identifier.epage838en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWatersMetenier, SL=36550861500en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.citeulike8415282-

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