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Article: Expanding the range of ZNF804A variants conferring risk of psychosis

TitleExpanding the range of ZNF804A variants conferring risk of psychosis
Authors
Keywordsassociation
bipolar disorder
CNV
schizophrenia
ZNF804A
Issue Date2011
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/mp
Citation
Molecular Psychiatry, 2011, v. 16 n. 1, p. 59-66 How to Cite?
AbstractA trio of genome-wide association studies recently reported sequence variants at three loci to be significantly associated with schizophrenia. No sequence polymorphism had been unequivocally (P5 × 10 8) associated with schizophrenia earlier. However, one variant, rs1344706T, had come very close. This polymorphism, located in an intron of ZNF804A, was reported to associate with schizophrenia with a P-value of 1.6 × 10 7, and with psychosis (schizophrenia plus bipolar disorder) with a P-value of 1.0 × 10 8. In this study, using 5164 schizophrenia cases and 20 709 controls, we replicated the association with schizophrenia (odds ratio OR1.08, P0.0029) and, by adding bipolar disorder patients, we also confirmed the association with psychosis (added N609, OR1.09, P0.00065). Furthermore, as it has been proposed that variants such as rs1344706Tcommon and with low relative riskmay also serve to identify regions harboring less common, higher-risk susceptibility alleles, we searched ZNF804A for large copy number variants (CNVs) in 4235 psychosis patients, 1173 patients with other psychiatric disorders and 39 481 controls. We identified two CNVs including at least part of ZNF804A in psychosis patients and no ZNF804A CNVs in controls (P0.013 for association with psychosis). In addition, we found a ZNF804A CNV in an anxiety patient (P0.0016 for association with the larger set of psychiatric disorders). © 2011 Macmillan Publishers Limited All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/141826
ISSN
2015 Impact Factor: 13.314
2015 SCImago Journal Rankings: 6.790
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
European UnionLSHM-CT-2006-037761
PIAP-GA-2008-218251
HEALTH-F2-2009-223423
National Genomic Network (NGFN-2) of the German Federal Ministry of Education and Research (BMBF)
National Institute of Mental HealthR01 MH078075
Center of Excellence for Complex Disease Genetics of the Academy of Finland213506
129680
Biocentrum Helsinki Foundation and Faculty of Medicine, University of Helsinki
Funding Information:

We thank the subjects, their families and the recruitment center staff. This work was supported by the European Union (LSHM-CT-2006-037761 (Project SGENE), PIAP-GA-2008-218251 (Project PsychGene) and HEALTH-F2-2009-223423 (Project PsychCNVs)), the National Genomic Network (NGFN-2) of the German Federal Ministry of Education and Research (BMBF), the National Institute of Mental Health (R01 MH078075), the Center of Excellence for Complex Disease Genetics of the Academy of Finland (Grants 213506, 129680) and the Biocentrum Helsinki Foundation and Research Program for Molecular Medicine, Faculty of Medicine, University of Helsinki.

References

 

DC FieldValueLanguage
dc.contributor.authorSteinberg, Sen_HK
dc.contributor.authorMors, Oen_HK
dc.contributor.authorBørglum, ADen_HK
dc.contributor.authorGustafsson, Oen_HK
dc.contributor.authorWerge, Ten_HK
dc.contributor.authorMortensen, PBen_HK
dc.contributor.authorAndreassen, OAen_HK
dc.contributor.authorSigurdsson, Een_HK
dc.contributor.authorThorgeirsson, TEen_HK
dc.contributor.authorBöttcher, Yen_HK
dc.contributor.authorOlason, Pen_HK
dc.contributor.authorOphoff, RAen_HK
dc.contributor.authorCichon, Sen_HK
dc.contributor.authorGudjonsdottir, IHen_HK
dc.contributor.authorPietiläinen, OPHen_HK
dc.contributor.authorNyegaard, Men_HK
dc.contributor.authorTuulioHenriksson, Aen_HK
dc.contributor.authorIngason, Aen_HK
dc.contributor.authorHansen, Ten_HK
dc.contributor.authorAthanasiu, Len_HK
dc.contributor.authorSuvisaari, Jen_HK
dc.contributor.authorLonnqvist, Jen_HK
dc.contributor.authorPaunio, Ten_HK
dc.contributor.authorHartmann, Aen_HK
dc.contributor.authorJürgens, Gen_HK
dc.contributor.authorNordentoft, Men_HK
dc.contributor.authorHougaard, Den_HK
dc.contributor.authorNorgaardPedersen, Ben_HK
dc.contributor.authorBreuer, Ren_HK
dc.contributor.authorMöller, HJen_HK
dc.contributor.authorGiegling, Ien_HK
dc.contributor.authorGlenthøj, Ben_HK
dc.contributor.authorRasmussen, HBen_HK
dc.contributor.authorMattheisen, Men_HK
dc.contributor.authorBitter, Ien_HK
dc.contributor.authorRéthelyi, JMen_HK
dc.contributor.authorSigmundsson, Ten_HK
dc.contributor.authorFossdal, Ren_HK
dc.contributor.authorThorsteinsdottir, Uen_HK
dc.contributor.authorRuggeri, Men_HK
dc.contributor.authorTosato, Sen_HK
dc.contributor.authorStrengman, Een_HK
dc.contributor.authorKiemeney, LAen_HK
dc.contributor.authorMelle, Ien_HK
dc.contributor.authorDjurovic, Sen_HK
dc.contributor.authorAbramova, Len_HK
dc.contributor.authorKaleda, Ven_HK
dc.contributor.authorWalshe, Men_HK
dc.contributor.authorBramon, Een_HK
dc.contributor.authorVassos, Een_HK
dc.contributor.authorLi, Ten_HK
dc.contributor.authorFraser, Gen_HK
dc.contributor.authorWalker, Nen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorYoon, Jen_HK
dc.contributor.authorFreimer, NBen_HK
dc.contributor.authorCantor, RMen_HK
dc.contributor.authorMurray, Ren_HK
dc.contributor.authorKong, Aen_HK
dc.contributor.authorGolimbet, Ven_HK
dc.contributor.authorJönsson, EGen_HK
dc.contributor.authorTerenius, Len_HK
dc.contributor.authorAgartz, Ien_HK
dc.contributor.authorPetursson, Hen_HK
dc.contributor.authorNöthen, MMen_HK
dc.contributor.authorRietschel, Men_HK
dc.contributor.authorPeltonen, Len_HK
dc.contributor.authorRujescu, Den_HK
dc.contributor.authorCollier, DAen_HK
dc.contributor.authorStefansson, Hen_HK
dc.contributor.authorSt Clair, Den_HK
dc.contributor.authorStefansson, Ken_HK
dc.date.accessioned2011-09-27T03:02:44Z-
dc.date.available2011-09-27T03:02:44Z-
dc.date.issued2011en_HK
dc.identifier.citationMolecular Psychiatry, 2011, v. 16 n. 1, p. 59-66en_HK
dc.identifier.issn1359-4184en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141826-
dc.description.abstractA trio of genome-wide association studies recently reported sequence variants at three loci to be significantly associated with schizophrenia. No sequence polymorphism had been unequivocally (P5 × 10 8) associated with schizophrenia earlier. However, one variant, rs1344706T, had come very close. This polymorphism, located in an intron of ZNF804A, was reported to associate with schizophrenia with a P-value of 1.6 × 10 7, and with psychosis (schizophrenia plus bipolar disorder) with a P-value of 1.0 × 10 8. In this study, using 5164 schizophrenia cases and 20 709 controls, we replicated the association with schizophrenia (odds ratio OR1.08, P0.0029) and, by adding bipolar disorder patients, we also confirmed the association with psychosis (added N609, OR1.09, P0.00065). Furthermore, as it has been proposed that variants such as rs1344706Tcommon and with low relative riskmay also serve to identify regions harboring less common, higher-risk susceptibility alleles, we searched ZNF804A for large copy number variants (CNVs) in 4235 psychosis patients, 1173 patients with other psychiatric disorders and 39 481 controls. We identified two CNVs including at least part of ZNF804A in psychosis patients and no ZNF804A CNVs in controls (P0.013 for association with psychosis). In addition, we found a ZNF804A CNV in an anxiety patient (P0.0016 for association with the larger set of psychiatric disorders). © 2011 Macmillan Publishers Limited All rights reserved.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/mpen_HK
dc.relation.ispartofMolecular Psychiatryen_HK
dc.subjectassociationen_HK
dc.subjectbipolar disorderen_HK
dc.subjectCNVen_HK
dc.subjectschizophreniaen_HK
dc.subjectZNF804Aen_HK
dc.titleExpanding the range of ZNF804A variants conferring risk of psychosisen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1038/mp.2009.149en_HK
dc.identifier.pmid20048749-
dc.identifier.pmcidPMC3242031-
dc.identifier.scopuseid_2-s2.0-78650516986en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78650516986&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue1en_HK
dc.identifier.spage59en_HK
dc.identifier.epage66en_HK
dc.identifier.eissn1476-5578-
dc.identifier.isiWOS:000285546400007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridSteinberg, S=22735361200en_HK
dc.identifier.scopusauthoridMors, O=7004006411en_HK
dc.identifier.scopusauthoridBørglum, AD=7004609664en_HK
dc.identifier.scopusauthoridGustafsson, O=26023239200en_HK
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dc.identifier.scopusauthoridStefansson, K=7005997553en_HK
dc.identifier.citeulike6498548-

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