Article: Expanding the range of ZNF804A variants conferring risk of psychosis

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TitleExpanding the range of ZNF804A variants conferring risk of psychosis
AuthorsSteinberg, S
Mors, O22
Børglum, AD9 22
Gustafsson, O8
Werge, T4
Mortensen, PB9
Andreassen, OA8
Sigurdsson, E5 24
Thorgeirsson, TE
Böttcher, Y
Olason, P
Ophoff, RA10 27
Cichon, S3
Gudjonsdottir, IH
Pietiläinen, OPH7 13
Nyegaard, M9
TuulioHenriksson, A12
Ingason, A
Hansen, T4
Athanasiu, L8
Suvisaari, J12
Lonnqvist, J12
Paunio, T20
Hartmann, A1
Jürgens, G17
Nordentoft, M17
Hougaard, D11
NorgaardPedersen, B15
Breuer, R16
Möller, HJ
Giegling, I1
Glenthøj, B4
Rasmussen, HB4
Mattheisen, M10
Bitter, I28
Réthelyi, JM28
Sigmundsson, T5 24
Fossdal, R
Thorsteinsdottir, U5
Ruggeri, M25
Tosato, S25
Strengman, E27
Kiemeney, LA21
Melle, I8
Djurovic, S8
Abramova, L14
Kaleda, V14
Walshe, M2
Bramon, E2
Vassos, E2
Li, T2 26
Fraser, G6
Walker, N18
Toulopoulou, T2
Yoon, J23
Freimer, NB10
Cantor, RM10 23
Murray, R2
Kong, A
Golimbet, V14
Jönsson, EG19
Terenius, L19
Agartz, I19
Petursson, H5 24
Nöthen, MM3
Rietschel, M16
Peltonen, L7 13
Rujescu, D1
Collier, DA2 26
Stefansson, H
St Clair, D6
Stefansson, K5
Keywordsassociation
bipolar disorder
CNV
schizophrenia
ZNF804A
Issue Date2011
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/mp
CitationMolecular Psychiatry, 2011, v. 16 n. 1, p. 59-66 [How to Cite?]
DOI: http://dx.doi.org/10.1038/mp.2009.149
AbstractA trio of genome-wide association studies recently reported sequence variants at three loci to be significantly associated with schizophrenia. No sequence polymorphism had been unequivocally (P5 × 10 8) associated with schizophrenia earlier. However, one variant, rs1344706T, had come very close. This polymorphism, located in an intron of ZNF804A, was reported to associate with schizophrenia with a P-value of 1.6 × 10 7, and with psychosis (schizophrenia plus bipolar disorder) with a P-value of 1.0 × 10 8. In this study, using 5164 schizophrenia cases and 20 709 controls, we replicated the association with schizophrenia (odds ratio OR1.08, P0.0029) and, by adding bipolar disorder patients, we also confirmed the association with psychosis (added N609, OR1.09, P0.00065). Furthermore, as it has been proposed that variants such as rs1344706Tcommon and with low relative riskmay also serve to identify regions harboring less common, higher-risk susceptibility alleles, we searched ZNF804A for large copy number variants (CNVs) in 4235 psychosis patients, 1173 patients with other psychiatric disorders and 39 481 controls. We identified two CNVs including at least part of ZNF804A in psychosis patients and no ZNF804A CNVs in controls (P0.013 for association with psychosis). In addition, we found a ZNF804A CNV in an anxiety patient (P0.0016 for association with the larger set of psychiatric disorders). © 2011 Macmillan Publishers Limited All rights reserved.
ISSN1359-4184
2011 Impact Factor: 13.668
2011 SCImago Journal Rankings: 0.843
DOIhttp://dx.doi.org/10.1038/mp.2009.149
ISI Accession Number IDWOS:000285546400007
Funding AgencyGrant Number
European UnionLSHM-CT-2006-037761
PIAP-GA-2008-218251
HEALTH-F2-2009-223423
National Genomic Network (NGFN-2) of the German Federal Ministry of Education and Research (BMBF)
National Institute of Mental HealthR01 MH078075
Center of Excellence for Complex Disease Genetics of the Academy of Finland213506
129680
Biocentrum Helsinki Foundation and Faculty of Medicine, University of Helsinki
Funding Information:

We thank the subjects, their families and the recruitment center staff. This work was supported by the European Union (LSHM-CT-2006-037761 (Project SGENE), PIAP-GA-2008-218251 (Project PsychGene) and HEALTH-F2-2009-223423 (Project PsychCNVs)), the National Genomic Network (NGFN-2) of the German Federal Ministry of Education and Research (BMBF), the National Institute of Mental Health (R01 MH078075), the Center of Excellence for Complex Disease Genetics of the Academy of Finland (Grants 213506, 129680) and the Biocentrum Helsinki Foundation and Research Program for Molecular Medicine, Faculty of Medicine, University of Helsinki.

PubMed Central IDPMC3242031
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorSteinberg, S
dc.contributor.authorMors, O
dc.contributor.authorBørglum, AD
dc.contributor.authorGustafsson, O
dc.contributor.authorWerge, T
dc.contributor.authorMortensen, PB
dc.contributor.authorAndreassen, OA
dc.contributor.authorSigurdsson, E
dc.contributor.authorThorgeirsson, TE
dc.contributor.authorBöttcher, Y
dc.contributor.authorOlason, P
dc.contributor.authorOphoff, RA
dc.contributor.authorCichon, S
dc.contributor.authorGudjonsdottir, IH
dc.contributor.authorPietiläinen, OPH
dc.contributor.authorNyegaard, M
dc.contributor.authorTuulioHenriksson, A
dc.contributor.authorIngason, A
dc.contributor.authorHansen, T
dc.contributor.authorAthanasiu, L
dc.contributor.authorSuvisaari, J
dc.contributor.authorLonnqvist, J
dc.contributor.authorPaunio, T
dc.contributor.authorHartmann, A
dc.contributor.authorJürgens, G
dc.contributor.authorNordentoft, M
dc.contributor.authorHougaard, D
dc.contributor.authorNorgaardPedersen, B
dc.contributor.authorBreuer, R
dc.contributor.authorMöller, HJ
dc.contributor.authorGiegling, I
dc.contributor.authorGlenthøj, B
dc.contributor.authorRasmussen, HB
dc.contributor.authorMattheisen, M
dc.contributor.authorBitter, I
dc.contributor.authorRéthelyi, JM
dc.contributor.authorSigmundsson, T
dc.contributor.authorFossdal, R
dc.contributor.authorThorsteinsdottir, U
dc.contributor.authorRuggeri, M
dc.contributor.authorTosato, S
dc.contributor.authorStrengman, E
dc.contributor.authorKiemeney, LA
dc.contributor.authorMelle, I
dc.contributor.authorDjurovic, S
dc.contributor.authorAbramova, L
dc.contributor.authorKaleda, V
dc.contributor.authorWalshe, M
dc.contributor.authorBramon, E
dc.contributor.authorVassos, E
dc.contributor.authorLi, T
dc.contributor.authorFraser, G
dc.contributor.authorWalker, N
dc.contributor.authorToulopoulou, T
dc.contributor.authorYoon, J
dc.contributor.authorFreimer, NB
dc.contributor.authorCantor, RM
dc.contributor.authorMurray, R
dc.contributor.authorKong, A
dc.contributor.authorGolimbet, V
dc.contributor.authorJönsson, EG
dc.contributor.authorTerenius, L
dc.contributor.authorAgartz, I
dc.contributor.authorPetursson, H
dc.contributor.authorNöthen, MM
dc.contributor.authorRietschel, M
dc.contributor.authorPeltonen, L
dc.contributor.authorRujescu, D
dc.contributor.authorCollier, DA
dc.contributor.authorStefansson, H
dc.contributor.authorSt Clair, D
dc.contributor.authorStefansson, K
dc.date.accessioned2011-09-27T03:02:44Z
dc.date.available2011-09-27T03:02:44Z
dc.date.issued2011
dc.description.abstractA trio of genome-wide association studies recently reported sequence variants at three loci to be significantly associated with schizophrenia. No sequence polymorphism had been unequivocally (P5 × 10 8) associated with schizophrenia earlier. However, one variant, rs1344706T, had come very close. This polymorphism, located in an intron of ZNF804A, was reported to associate with schizophrenia with a P-value of 1.6 × 10 7, and with psychosis (schizophrenia plus bipolar disorder) with a P-value of 1.0 × 10 8. In this study, using 5164 schizophrenia cases and 20 709 controls, we replicated the association with schizophrenia (odds ratio OR1.08, P0.0029) and, by adding bipolar disorder patients, we also confirmed the association with psychosis (added N609, OR1.09, P0.00065). Furthermore, as it has been proposed that variants such as rs1344706Tcommon and with low relative riskmay also serve to identify regions harboring less common, higher-risk susceptibility alleles, we searched ZNF804A for large copy number variants (CNVs) in 4235 psychosis patients, 1173 patients with other psychiatric disorders and 39 481 controls. We identified two CNVs including at least part of ZNF804A in psychosis patients and no ZNF804A CNVs in controls (P0.013 for association with psychosis). In addition, we found a ZNF804A CNV in an anxiety patient (P0.0016 for association with the larger set of psychiatric disorders). © 2011 Macmillan Publishers Limited All rights reserved.
dc.description.naturelink_to_subscribed_fulltext
dc.identifier.citationMolecular Psychiatry, 2011, v. 16 n. 1, p. 59-66 [How to Cite?]
DOI: http://dx.doi.org/10.1038/mp.2009.149
dc.identifier.citeulike6498548
dc.identifier.doihttp://dx.doi.org/10.1038/mp.2009.149
dc.identifier.eissn1476-5578
dc.identifier.epage66
dc.identifier.isiWOS:000285546400007
Funding AgencyGrant Number
European UnionLSHM-CT-2006-037761
PIAP-GA-2008-218251
HEALTH-F2-2009-223423
National Genomic Network (NGFN-2) of the German Federal Ministry of Education and Research (BMBF)
National Institute of Mental HealthR01 MH078075
Center of Excellence for Complex Disease Genetics of the Academy of Finland213506
129680
Biocentrum Helsinki Foundation and Faculty of Medicine, University of Helsinki
Funding Information:

We thank the subjects, their families and the recruitment center staff. This work was supported by the European Union (LSHM-CT-2006-037761 (Project SGENE), PIAP-GA-2008-218251 (Project PsychGene) and HEALTH-F2-2009-223423 (Project PsychCNVs)), the National Genomic Network (NGFN-2) of the German Federal Ministry of Education and Research (BMBF), the National Institute of Mental Health (R01 MH078075), the Center of Excellence for Complex Disease Genetics of the Academy of Finland (Grants 213506, 129680) and the Biocentrum Helsinki Foundation and Research Program for Molecular Medicine, Faculty of Medicine, University of Helsinki.

dc.identifier.issn1359-4184
2011 Impact Factor: 13.668
2011 SCImago Journal Rankings: 0.843
dc.identifier.issue1
dc.identifier.pmcidPMC3242031
dc.identifier.pmid20048749
dc.identifier.scopuseid_2-s2.0-78650516986
dc.identifier.spage59
dc.identifier.urihttp://hdl.handle.net/10722/141826
dc.identifier.volume16
dc.languageeng
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/mp
dc.publisher.placeUnited Kingdom
dc.relation.ispartofMolecular Psychiatry
dc.relation.referencesReferences in Scopus
dc.subjectassociation
dc.subjectbipolar disorder
dc.subjectCNV
dc.subjectschizophrenia
dc.subjectZNF804A
dc.titleExpanding the range of ZNF804A variants conferring risk of psychosis
dc.typeArticle
Author Affiliations
  1. Ludwig-Maximilians-Universität München
  2. King's College London
  3. Universität Bonn
  4. Copenhagen University Hospital
  5. University of Iceland
  6. University of Aberdeen
  7. Helsingin Yliopisto
  8. Ulleval University Hospital
  9. Aarhus Universitet
  10. UCLA Medical Center
  11. Statens Serum Institut
  12. Kansanterveyslaitos
  13. Wellcome Trust Sanger Institute
  14. Russian Academy of Medical Sciences
  15. Amtssygehuset i Glostrup
  16. Universität Heidelberg
  17. Bispebjerg Hospital
  18. Ravenscraig Hospital
  19. Karolinska Institutet
  20. National Institute for Health and Welfare (THL)
  21. Radboud University Nijmegen Medical Centre
  22. Ârhus Universitetshospital
  23. University of California, Los Angeles
  24. National University Hospital
  25. Università degli Studi di Verona
  26. Sichuan University
  27. University Medical Center Utrecht
  28. Semmelweis Egyetem