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Article: Expanding the range of ZNF804A variants conferring risk of psychosis
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TitleExpanding the range of ZNF804A variants conferring risk of psychosis
 
AuthorsSteinberg, S
Mors, O22
Børglum, AD9 22
Gustafsson, O8
Werge, T1
Mortensen, PB9
Andreassen, OA8
Sigurdsson, E23 5
Thorgeirsson, TE
Böttcher, Y
Olason, P
Ophoff, RA27 11
Cichon, S4
Gudjonsdottir, IH
Pietiläinen, OPH7 16
Nyegaard, M9
TuulioHenriksson, A17
Ingason, A
Hansen, T1
Athanasiu, L8
Suvisaari, J17
Lonnqvist, J17
Paunio, T
Hartmann, A2
Jürgens, G15
Nordentoft, M15
Hougaard, D10
NorgaardPedersen, B12
Breuer, R13
Möller, HJ2
Giegling, I2
Glenthøj, B1
Rasmussen, HB1
Mattheisen, M11
Bitter, I25
Réthelyi, JM25
Sigmundsson, T23 5
Fossdal, R
Thorsteinsdottir, U5
Ruggeri, M24
Tosato, S24
Strengman, E27
Kiemeney, LA20
Melle, I8
Djurovic, S8
Abramova, L14
Kaleda, V14
Walshe, M3
Bramon, E3
Vassos, E3
Li, T26 3
Fraser, G6
Walker, N18
Toulopoulou, T3
Yoon, J21
Freimer, NB11
Cantor, RM21 11
Murray, R3
Kong, A
Golimbet, V14
Jönsson, EG19
Terenius, L19
Agartz, I19
Petursson, H23 5
Nöthen, MM4
Rietschel, M13
Peltonen, L7 16
Rujescu, D2
Collier, DA26 3
Stefansson, H
St Clair, D6
Stefansson, K5
 
Keywordsassociation
bipolar disorder
CNV
schizophrenia
ZNF804A
 
Issue Date2011
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/mp
 
CitationMolecular Psychiatry, 2011, v. 16 n. 1, p. 59-66 [How to Cite?]
DOI: http://dx.doi.org/10.1038/mp.2009.149
 
AbstractA trio of genome-wide association studies recently reported sequence variants at three loci to be significantly associated with schizophrenia. No sequence polymorphism had been unequivocally (P5 × 10 8) associated with schizophrenia earlier. However, one variant, rs1344706T, had come very close. This polymorphism, located in an intron of ZNF804A, was reported to associate with schizophrenia with a P-value of 1.6 × 10 7, and with psychosis (schizophrenia plus bipolar disorder) with a P-value of 1.0 × 10 8. In this study, using 5164 schizophrenia cases and 20 709 controls, we replicated the association with schizophrenia (odds ratio OR1.08, P0.0029) and, by adding bipolar disorder patients, we also confirmed the association with psychosis (added N609, OR1.09, P0.00065). Furthermore, as it has been proposed that variants such as rs1344706Tcommon and with low relative riskmay also serve to identify regions harboring less common, higher-risk susceptibility alleles, we searched ZNF804A for large copy number variants (CNVs) in 4235 psychosis patients, 1173 patients with other psychiatric disorders and 39 481 controls. We identified two CNVs including at least part of ZNF804A in psychosis patients and no ZNF804A CNVs in controls (P0.013 for association with psychosis). In addition, we found a ZNF804A CNV in an anxiety patient (P0.0016 for association with the larger set of psychiatric disorders). © 2011 Macmillan Publishers Limited All rights reserved.
 
ISSN1359-4184
2012 Impact Factor: 14.897
2012 SCImago Journal Rankings: 5.117
 
DOIhttp://dx.doi.org/10.1038/mp.2009.149
 
PubMed Central IDPMC3242031
 
ISI Accession Number IDWOS:000285546400007
Funding AgencyGrant Number
European UnionLSHM-CT-2006-037761
PIAP-GA-2008-218251
HEALTH-F2-2009-223423
National Genomic Network (NGFN-2) of the German Federal Ministry of Education and Research (BMBF)
National Institute of Mental HealthR01 MH078075
Center of Excellence for Complex Disease Genetics of the Academy of Finland213506
129680
Biocentrum Helsinki Foundation and Faculty of Medicine, University of Helsinki
Funding Information:

We thank the subjects, their families and the recruitment center staff. This work was supported by the European Union (LSHM-CT-2006-037761 (Project SGENE), PIAP-GA-2008-218251 (Project PsychGene) and HEALTH-F2-2009-223423 (Project PsychCNVs)), the National Genomic Network (NGFN-2) of the German Federal Ministry of Education and Research (BMBF), the National Institute of Mental Health (R01 MH078075), the Center of Excellence for Complex Disease Genetics of the Academy of Finland (Grants 213506, 129680) and the Biocentrum Helsinki Foundation and Research Program for Molecular Medicine, Faculty of Medicine, University of Helsinki.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorSteinberg, S
 
dc.contributor.authorMors, O
 
dc.contributor.authorBørglum, AD
 
dc.contributor.authorGustafsson, O
 
dc.contributor.authorWerge, T
 
dc.contributor.authorMortensen, PB
 
dc.contributor.authorAndreassen, OA
 
dc.contributor.authorSigurdsson, E
 
dc.contributor.authorThorgeirsson, TE
 
dc.contributor.authorBöttcher, Y
 
dc.contributor.authorOlason, P
 
dc.contributor.authorOphoff, RA
 
dc.contributor.authorCichon, S
 
dc.contributor.authorGudjonsdottir, IH
 
dc.contributor.authorPietiläinen, OPH
 
dc.contributor.authorNyegaard, M
 
dc.contributor.authorTuulioHenriksson, A
 
dc.contributor.authorIngason, A
 
dc.contributor.authorHansen, T
 
dc.contributor.authorAthanasiu, L
 
dc.contributor.authorSuvisaari, J
 
dc.contributor.authorLonnqvist, J
 
dc.contributor.authorPaunio, T
 
dc.contributor.authorHartmann, A
 
dc.contributor.authorJürgens, G
 
dc.contributor.authorNordentoft, M
 
dc.contributor.authorHougaard, D
 
dc.contributor.authorNorgaardPedersen, B
 
dc.contributor.authorBreuer, R
 
dc.contributor.authorMöller, HJ
 
dc.contributor.authorGiegling, I
 
dc.contributor.authorGlenthøj, B
 
dc.contributor.authorRasmussen, HB
 
dc.contributor.authorMattheisen, M
 
dc.contributor.authorBitter, I
 
dc.contributor.authorRéthelyi, JM
 
dc.contributor.authorSigmundsson, T
 
dc.contributor.authorFossdal, R
 
dc.contributor.authorThorsteinsdottir, U
 
dc.contributor.authorRuggeri, M
 
dc.contributor.authorTosato, S
 
dc.contributor.authorStrengman, E
 
dc.contributor.authorKiemeney, LA
 
dc.contributor.authorMelle, I
 
dc.contributor.authorDjurovic, S
 
dc.contributor.authorAbramova, L
 
dc.contributor.authorKaleda, V
 
dc.contributor.authorWalshe, M
 
dc.contributor.authorBramon, E
 
dc.contributor.authorVassos, E
 
dc.contributor.authorLi, T
 
dc.contributor.authorFraser, G
 
dc.contributor.authorWalker, N
 
dc.contributor.authorToulopoulou, T
 
dc.contributor.authorYoon, J
 
dc.contributor.authorFreimer, NB
 
dc.contributor.authorCantor, RM
 
dc.contributor.authorMurray, R
 
dc.contributor.authorKong, A
 
dc.contributor.authorGolimbet, V
 
dc.contributor.authorJönsson, EG
 
dc.contributor.authorTerenius, L
 
dc.contributor.authorAgartz, I
 
dc.contributor.authorPetursson, H
 
dc.contributor.authorNöthen, MM
 
dc.contributor.authorRietschel, M
 
dc.contributor.authorPeltonen, L
 
dc.contributor.authorRujescu, D
 
dc.contributor.authorCollier, DA
 
dc.contributor.authorStefansson, H
 
dc.contributor.authorSt Clair, D
 
dc.contributor.authorStefansson, K
 
dc.date.accessioned2011-09-27T03:02:44Z
 
dc.date.available2011-09-27T03:02:44Z
 
dc.date.issued2011
 
dc.description.abstractA trio of genome-wide association studies recently reported sequence variants at three loci to be significantly associated with schizophrenia. No sequence polymorphism had been unequivocally (P5 × 10 8) associated with schizophrenia earlier. However, one variant, rs1344706T, had come very close. This polymorphism, located in an intron of ZNF804A, was reported to associate with schizophrenia with a P-value of 1.6 × 10 7, and with psychosis (schizophrenia plus bipolar disorder) with a P-value of 1.0 × 10 8. In this study, using 5164 schizophrenia cases and 20 709 controls, we replicated the association with schizophrenia (odds ratio OR1.08, P0.0029) and, by adding bipolar disorder patients, we also confirmed the association with psychosis (added N609, OR1.09, P0.00065). Furthermore, as it has been proposed that variants such as rs1344706Tcommon and with low relative riskmay also serve to identify regions harboring less common, higher-risk susceptibility alleles, we searched ZNF804A for large copy number variants (CNVs) in 4235 psychosis patients, 1173 patients with other psychiatric disorders and 39 481 controls. We identified two CNVs including at least part of ZNF804A in psychosis patients and no ZNF804A CNVs in controls (P0.013 for association with psychosis). In addition, we found a ZNF804A CNV in an anxiety patient (P0.0016 for association with the larger set of psychiatric disorders). © 2011 Macmillan Publishers Limited All rights reserved.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationMolecular Psychiatry, 2011, v. 16 n. 1, p. 59-66 [How to Cite?]
DOI: http://dx.doi.org/10.1038/mp.2009.149
 
dc.identifier.citeulike6498548
 
dc.identifier.doihttp://dx.doi.org/10.1038/mp.2009.149
 
dc.identifier.eissn1476-5578
 
dc.identifier.epage66
 
dc.identifier.isiWOS:000285546400007
Funding AgencyGrant Number
European UnionLSHM-CT-2006-037761
PIAP-GA-2008-218251
HEALTH-F2-2009-223423
National Genomic Network (NGFN-2) of the German Federal Ministry of Education and Research (BMBF)
National Institute of Mental HealthR01 MH078075
Center of Excellence for Complex Disease Genetics of the Academy of Finland213506
129680
Biocentrum Helsinki Foundation and Faculty of Medicine, University of Helsinki
Funding Information:

We thank the subjects, their families and the recruitment center staff. This work was supported by the European Union (LSHM-CT-2006-037761 (Project SGENE), PIAP-GA-2008-218251 (Project PsychGene) and HEALTH-F2-2009-223423 (Project PsychCNVs)), the National Genomic Network (NGFN-2) of the German Federal Ministry of Education and Research (BMBF), the National Institute of Mental Health (R01 MH078075), the Center of Excellence for Complex Disease Genetics of the Academy of Finland (Grants 213506, 129680) and the Biocentrum Helsinki Foundation and Research Program for Molecular Medicine, Faculty of Medicine, University of Helsinki.

 
dc.identifier.issn1359-4184
2012 Impact Factor: 14.897
2012 SCImago Journal Rankings: 5.117
 
dc.identifier.issue1
 
dc.identifier.pmcidPMC3242031
 
dc.identifier.pmid20048749
 
dc.identifier.scopuseid_2-s2.0-78650516986
 
dc.identifier.spage59
 
dc.identifier.urihttp://hdl.handle.net/10722/141826
 
dc.identifier.volume16
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/mp
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofMolecular Psychiatry
 
dc.relation.referencesReferences in Scopus
 
dc.subjectassociation
 
dc.subjectbipolar disorder
 
dc.subjectCNV
 
dc.subjectschizophrenia
 
dc.subjectZNF804A
 
dc.titleExpanding the range of ZNF804A variants conferring risk of psychosis
 
dc.typeArticle
 
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Author Affiliations
  1. Copenhagen University Hospital
  2. Ludwig-Maximilians-Universität München
  3. King's College London
  4. Universität Bonn
  5. University of Iceland
  6. University of Aberdeen
  7. Helsingin Yliopisto
  8. Ulleval University Hospital
  9. Aarhus Universitet
  10. Statens Serum Institut
  11. UCLA Medical Center
  12. Amtssygehuset i Glostrup
  13. Universität Heidelberg
  14. Russian Academy of Medical Sciences
  15. Bispebjerg Hospital
  16. Wellcome Trust Sanger Institute
  17. Kansanterveyslaitos
  18. Ravenscraig Hospital
  19. Karolinska Institutet
  20. Radboud University Nijmegen Medical Centre
  21. University of California, Los Angeles
  22. Ârhus Universitetshospital
  23. National University Hospital
  24. Università degli Studi di Verona
  25. Semmelweis Egyetem
  26. Sichuan University
  27. University Medical Center Utrecht