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Article: Pattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorder

TitlePattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorder
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2011
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcpsychiatr/
Citation
Bmc Psychiatry, 2011, v. 11 How to Cite?
AbstractBackground: Impairments in executive function and language processing are characteristic of both schizophrenia and bipolar disorder. Their functional neuroanatomy demonstrate features that are shared as well as specific to each disorder. Determining the distinct pattern of neural responses in schizophrenia and bipolar disorder may provide biomarkers for their diagnoses.Methods: 104 participants underwent functional magnetic resonance imaging (fMRI) scans while performing a phonological verbal fluency task. Subjects were 32 patients with schizophrenia in remission, 32 patients with bipolar disorder in an euthymic state, and 40 healthy volunteers. Neural responses to verbal fluency were examined in each group, and the diagnostic potential of the pattern of the neural responses was assessed with machine learning analysis.Results: During the verbal fluency task, both patient groups showed increased activation in the anterior cingulate, left dorsolateral prefrontal cortex and right putamen as compared to healthy controls, as well as reduced deactivation of precuneus and posterior cingulate. The magnitude of activation was greatest in patients with schizophrenia, followed by patients with bipolar disorder and then healthy individuals. Additional recruitment in the right inferior frontal and right dorsolateral prefrontal cortices was observed in schizophrenia relative to both bipolar disorder and healthy subjects. The pattern of neural responses correctly identified individual patients with schizophrenia with an accuracy of 92%, and those with bipolar disorder with an accuracy of 79% in which mis-classification was typically of bipolar subjects as healthy controls.Conclusions: In summary, both schizophrenia and bipolar disorder are associated with altered function in prefrontal, striatal and default mode networks, but the magnitude of this dysfunction is particularly marked in schizophrenia. The pattern of response to verbal fluency is highly diagnostic for schizophrenia and distinct from bipolar disorder. Pattern classification of functional MRI measurements of language processing is a potential diagnostic marker of schizophrenia. © 2011 Costafreda et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/141824
ISSN
2014 Impact Factor: 2.210
2014 SCImago Journal Rankings: 1.005
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
National Institute for Health Research (NIHR) Specialist Biomedical Research Centre for Mental Health
Maudsley NHS Foundation Trust
Institute of Psychiatry, King's College London
Funding Information:

SGC acknowledges support from the National Institute for Health Research (NIHR) Specialist Biomedical Research Centre for Mental Health award to the South London and Maudsley NHS Foundation Trust and the Institute of Psychiatry, King's College London.

References

 

DC FieldValueLanguage
dc.contributor.authorCostafreda, SGen_HK
dc.contributor.authorFu, CHYen_HK
dc.contributor.authorPicchioni, Men_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorMcDonald, Cen_HK
dc.contributor.authorKravariti, Een_HK
dc.contributor.authorWalshe, Men_HK
dc.contributor.authorPrata, Den_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorMcGuire, PKen_HK
dc.date.accessioned2011-09-27T03:02:38Z-
dc.date.available2011-09-27T03:02:38Z-
dc.date.issued2011en_HK
dc.identifier.citationBmc Psychiatry, 2011, v. 11en_HK
dc.identifier.issn1471-244Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/141824-
dc.description.abstractBackground: Impairments in executive function and language processing are characteristic of both schizophrenia and bipolar disorder. Their functional neuroanatomy demonstrate features that are shared as well as specific to each disorder. Determining the distinct pattern of neural responses in schizophrenia and bipolar disorder may provide biomarkers for their diagnoses.Methods: 104 participants underwent functional magnetic resonance imaging (fMRI) scans while performing a phonological verbal fluency task. Subjects were 32 patients with schizophrenia in remission, 32 patients with bipolar disorder in an euthymic state, and 40 healthy volunteers. Neural responses to verbal fluency were examined in each group, and the diagnostic potential of the pattern of the neural responses was assessed with machine learning analysis.Results: During the verbal fluency task, both patient groups showed increased activation in the anterior cingulate, left dorsolateral prefrontal cortex and right putamen as compared to healthy controls, as well as reduced deactivation of precuneus and posterior cingulate. The magnitude of activation was greatest in patients with schizophrenia, followed by patients with bipolar disorder and then healthy individuals. Additional recruitment in the right inferior frontal and right dorsolateral prefrontal cortices was observed in schizophrenia relative to both bipolar disorder and healthy subjects. The pattern of neural responses correctly identified individual patients with schizophrenia with an accuracy of 92%, and those with bipolar disorder with an accuracy of 79% in which mis-classification was typically of bipolar subjects as healthy controls.Conclusions: In summary, both schizophrenia and bipolar disorder are associated with altered function in prefrontal, striatal and default mode networks, but the magnitude of this dysfunction is particularly marked in schizophrenia. The pattern of response to verbal fluency is highly diagnostic for schizophrenia and distinct from bipolar disorder. Pattern classification of functional MRI measurements of language processing is a potential diagnostic marker of schizophrenia. © 2011 Costafreda et al; licensee BioMed Central Ltd.en_HK
dc.languageengen_US
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcpsychiatr/en_HK
dc.relation.ispartofBMC Psychiatryen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.titlePattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorderen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1186/1471-244X-11-18en_HK
dc.identifier.pmid21276242-
dc.identifier.pmcidPMC3042380-
dc.identifier.scopuseid_2-s2.0-79251561866en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79251561866&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.isiWOS:000287532900001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCostafreda, SG=8916108100en_HK
dc.identifier.scopusauthoridFu, CHY=8502155300en_HK
dc.identifier.scopusauthoridPicchioni, M=6507443795en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridMcDonald, C=8749594800en_HK
dc.identifier.scopusauthoridKravariti, E=8855469000en_HK
dc.identifier.scopusauthoridWalshe, M=8855469300en_HK
dc.identifier.scopusauthoridPrata, D=14632352500en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridMcGuire, PK=7101880438en_HK
dc.identifier.citeulike9473639-

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