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Article: Pattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorder
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TitlePattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorder
 
AuthorsCostafreda, SG1
Fu, CHY1
Picchioni, M1
Toulopoulou, T1
McDonald, C1
Kravariti, E1
Walshe, M1
Prata, D1
Murray, RM1
McGuire, PK1
 
KeywordsChemicals And Cas Registry Numbers
 
Issue Date2011
 
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcpsychiatr/
 
CitationBmc Psychiatry, 2011, v. 11 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1471-244X-11-18
 
AbstractBackground: Impairments in executive function and language processing are characteristic of both schizophrenia and bipolar disorder. Their functional neuroanatomy demonstrate features that are shared as well as specific to each disorder. Determining the distinct pattern of neural responses in schizophrenia and bipolar disorder may provide biomarkers for their diagnoses.Methods: 104 participants underwent functional magnetic resonance imaging (fMRI) scans while performing a phonological verbal fluency task. Subjects were 32 patients with schizophrenia in remission, 32 patients with bipolar disorder in an euthymic state, and 40 healthy volunteers. Neural responses to verbal fluency were examined in each group, and the diagnostic potential of the pattern of the neural responses was assessed with machine learning analysis.Results: During the verbal fluency task, both patient groups showed increased activation in the anterior cingulate, left dorsolateral prefrontal cortex and right putamen as compared to healthy controls, as well as reduced deactivation of precuneus and posterior cingulate. The magnitude of activation was greatest in patients with schizophrenia, followed by patients with bipolar disorder and then healthy individuals. Additional recruitment in the right inferior frontal and right dorsolateral prefrontal cortices was observed in schizophrenia relative to both bipolar disorder and healthy subjects. The pattern of neural responses correctly identified individual patients with schizophrenia with an accuracy of 92%, and those with bipolar disorder with an accuracy of 79% in which mis-classification was typically of bipolar subjects as healthy controls.Conclusions: In summary, both schizophrenia and bipolar disorder are associated with altered function in prefrontal, striatal and default mode networks, but the magnitude of this dysfunction is particularly marked in schizophrenia. The pattern of response to verbal fluency is highly diagnostic for schizophrenia and distinct from bipolar disorder. Pattern classification of functional MRI measurements of language processing is a potential diagnostic marker of schizophrenia. © 2011 Costafreda et al; licensee BioMed Central Ltd.
 
ISSN1471-244X
2012 Impact Factor: 2.233
2012 SCImago Journal Rankings: 1.017
 
DOIhttp://dx.doi.org/10.1186/1471-244X-11-18
 
PubMed Central IDPMC3042380
 
ISI Accession Number IDWOS:000287532900001
Funding AgencyGrant Number
National Institute for Health Research (NIHR) Specialist Biomedical Research Centre for Mental Health
Maudsley NHS Foundation Trust
Institute of Psychiatry, King's College London
Funding Information:

SGC acknowledges support from the National Institute for Health Research (NIHR) Specialist Biomedical Research Centre for Mental Health award to the South London and Maudsley NHS Foundation Trust and the Institute of Psychiatry, King's College London.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorCostafreda, SG
 
dc.contributor.authorFu, CHY
 
dc.contributor.authorPicchioni, M
 
dc.contributor.authorToulopoulou, T
 
dc.contributor.authorMcDonald, C
 
dc.contributor.authorKravariti, E
 
dc.contributor.authorWalshe, M
 
dc.contributor.authorPrata, D
 
dc.contributor.authorMurray, RM
 
dc.contributor.authorMcGuire, PK
 
dc.date.accessioned2011-09-27T03:02:38Z
 
dc.date.available2011-09-27T03:02:38Z
 
dc.date.issued2011
 
dc.description.abstractBackground: Impairments in executive function and language processing are characteristic of both schizophrenia and bipolar disorder. Their functional neuroanatomy demonstrate features that are shared as well as specific to each disorder. Determining the distinct pattern of neural responses in schizophrenia and bipolar disorder may provide biomarkers for their diagnoses.Methods: 104 participants underwent functional magnetic resonance imaging (fMRI) scans while performing a phonological verbal fluency task. Subjects were 32 patients with schizophrenia in remission, 32 patients with bipolar disorder in an euthymic state, and 40 healthy volunteers. Neural responses to verbal fluency were examined in each group, and the diagnostic potential of the pattern of the neural responses was assessed with machine learning analysis.Results: During the verbal fluency task, both patient groups showed increased activation in the anterior cingulate, left dorsolateral prefrontal cortex and right putamen as compared to healthy controls, as well as reduced deactivation of precuneus and posterior cingulate. The magnitude of activation was greatest in patients with schizophrenia, followed by patients with bipolar disorder and then healthy individuals. Additional recruitment in the right inferior frontal and right dorsolateral prefrontal cortices was observed in schizophrenia relative to both bipolar disorder and healthy subjects. The pattern of neural responses correctly identified individual patients with schizophrenia with an accuracy of 92%, and those with bipolar disorder with an accuracy of 79% in which mis-classification was typically of bipolar subjects as healthy controls.Conclusions: In summary, both schizophrenia and bipolar disorder are associated with altered function in prefrontal, striatal and default mode networks, but the magnitude of this dysfunction is particularly marked in schizophrenia. The pattern of response to verbal fluency is highly diagnostic for schizophrenia and distinct from bipolar disorder. Pattern classification of functional MRI measurements of language processing is a potential diagnostic marker of schizophrenia. © 2011 Costafreda et al; licensee BioMed Central Ltd.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationBmc Psychiatry, 2011, v. 11 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1471-244X-11-18
 
dc.identifier.citeulike9473639
 
dc.identifier.doihttp://dx.doi.org/10.1186/1471-244X-11-18
 
dc.identifier.isiWOS:000287532900001
Funding AgencyGrant Number
National Institute for Health Research (NIHR) Specialist Biomedical Research Centre for Mental Health
Maudsley NHS Foundation Trust
Institute of Psychiatry, King's College London
Funding Information:

SGC acknowledges support from the National Institute for Health Research (NIHR) Specialist Biomedical Research Centre for Mental Health award to the South London and Maudsley NHS Foundation Trust and the Institute of Psychiatry, King's College London.

 
dc.identifier.issn1471-244X
2012 Impact Factor: 2.233
2012 SCImago Journal Rankings: 1.017
 
dc.identifier.pmcidPMC3042380
 
dc.identifier.pmid21276242
 
dc.identifier.scopuseid_2-s2.0-79251561866
 
dc.identifier.urihttp://hdl.handle.net/10722/141824
 
dc.identifier.volume11
 
dc.languageeng
 
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcpsychiatr/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofBMC Psychiatry
 
dc.relation.referencesReferences in Scopus
 
dc.subjectChemicals And Cas Registry Numbers
 
dc.titlePattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorder
 
dc.typeArticle
 
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<contributor.author>Walshe, M</contributor.author>
<contributor.author>Prata, D</contributor.author>
<contributor.author>Murray, RM</contributor.author>
<contributor.author>McGuire, PK</contributor.author>
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Author Affiliations
  1. King's College London