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Article: Do COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis?
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TitleDo COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis?
 
AuthorsShaikh, M
Hall, MH3
Schulze, K
Dutt, A
Walshe, M
Williams, I
Constante, M
Picchioni, M1
Toulopoulou, T
Collier, D
Rijsdijk, F2
Powell, J
Arranz, M
Murray, RM
Bramon, E
 
KeywordsBDNF
COMT
NRG1
P50
psychosis
 
Issue Date2011
 
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
 
CitationPsychological Medicine, 2011, v. 41 n. 2, p. 263-276 [How to Cite?]
DOI: http://dx.doi.org/10.1017/S003329170999239X
 
AbstractBackground Auditory P50 sensory gating deficits correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease. The well-supported role of catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF) and neuregulin 1 (NRG1) genes in neurodevelopment and cognition make a strong theoretical case for their influence on the P50 endophenotype.Method The possible role of NRG1, COMT Val 158Met and BDNF Val 66Met gene polymorphisms on the P50 endophenotype was examined in a large sample consisting of psychotic patients, their unaffected relatives and unrelated healthy controls using linear regression analyses.Results Although P50 deficits were present in patients and their unaffected relatives, there was no evidence for an association between NRG1, COMT Val 158Met or BDNF Val 66Met genotypes and the P50 endophenotype.Conclusions The evidence from our large study suggests that any such association between P50 indices and NRG1, COMT Val 158Met or BDNF Val 66Met genotypes, if present, must be very subtle. © 2010 Cambridge University Press.
 
ISSN0033-2917
2013 Impact Factor: 5.428
 
DOIhttp://dx.doi.org/10.1017/S003329170999239X
 
ISI Accession Number IDWOS:000286072900004
Funding AgencyGrant Number
Wellcome Trust
Schizophrenia Research Fund
National Alliance for Research on Schizophrenia and Depression
British Medical Association
Psychiatry Research Trust
National Institute for Health Research (NIHR) Biomedical Research Centre
Funding Information:

We are grateful to all those who participated in our research study. This study was funded by the Wellcome Trust, the Schizophrenia Research Fund, the National Alliance for Research on Schizophrenia and Depression, the British Medical Association and the Psychiatry Research Trust. We also thank the National Institute for Health Research (NIHR) Biomedical Research Centre for financial support.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorShaikh, M
 
dc.contributor.authorHall, MH
 
dc.contributor.authorSchulze, K
 
dc.contributor.authorDutt, A
 
dc.contributor.authorWalshe, M
 
dc.contributor.authorWilliams, I
 
dc.contributor.authorConstante, M
 
dc.contributor.authorPicchioni, M
 
dc.contributor.authorToulopoulou, T
 
dc.contributor.authorCollier, D
 
dc.contributor.authorRijsdijk, F
 
dc.contributor.authorPowell, J
 
dc.contributor.authorArranz, M
 
dc.contributor.authorMurray, RM
 
dc.contributor.authorBramon, E
 
dc.date.accessioned2011-09-27T03:02:37Z
 
dc.date.available2011-09-27T03:02:37Z
 
dc.date.issued2011
 
dc.description.abstractBackground Auditory P50 sensory gating deficits correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease. The well-supported role of catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF) and neuregulin 1 (NRG1) genes in neurodevelopment and cognition make a strong theoretical case for their influence on the P50 endophenotype.Method The possible role of NRG1, COMT Val 158Met and BDNF Val 66Met gene polymorphisms on the P50 endophenotype was examined in a large sample consisting of psychotic patients, their unaffected relatives and unrelated healthy controls using linear regression analyses.Results Although P50 deficits were present in patients and their unaffected relatives, there was no evidence for an association between NRG1, COMT Val 158Met or BDNF Val 66Met genotypes and the P50 endophenotype.Conclusions The evidence from our large study suggests that any such association between P50 indices and NRG1, COMT Val 158Met or BDNF Val 66Met genotypes, if present, must be very subtle. © 2010 Cambridge University Press.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationPsychological Medicine, 2011, v. 41 n. 2, p. 263-276 [How to Cite?]
DOI: http://dx.doi.org/10.1017/S003329170999239X
 
dc.identifier.doihttp://dx.doi.org/10.1017/S003329170999239X
 
dc.identifier.eissn1469-8978
 
dc.identifier.epage276
 
dc.identifier.isiWOS:000286072900004
Funding AgencyGrant Number
Wellcome Trust
Schizophrenia Research Fund
National Alliance for Research on Schizophrenia and Depression
British Medical Association
Psychiatry Research Trust
National Institute for Health Research (NIHR) Biomedical Research Centre
Funding Information:

We are grateful to all those who participated in our research study. This study was funded by the Wellcome Trust, the Schizophrenia Research Fund, the National Alliance for Research on Schizophrenia and Depression, the British Medical Association and the Psychiatry Research Trust. We also thank the National Institute for Health Research (NIHR) Biomedical Research Centre for financial support.

 
dc.identifier.issn0033-2917
2013 Impact Factor: 5.428
 
dc.identifier.issue2
 
dc.identifier.pmid20102668
 
dc.identifier.scopuseid_2-s2.0-79952819313
 
dc.identifier.spage263
 
dc.identifier.urihttp://hdl.handle.net/10722/141823
 
dc.identifier.volume41
 
dc.languageeng
 
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofPsychological Medicine
 
dc.relation.referencesReferences in Scopus
 
dc.subjectBDNF
 
dc.subjectCOMT
 
dc.subjectNRG1
 
dc.subjectP50
 
dc.subjectpsychosis
 
dc.titleDo COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis?
 
dc.typeArticle
 
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<contributor.author>Walshe, M</contributor.author>
<contributor.author>Williams, I</contributor.author>
<contributor.author>Constante, M</contributor.author>
<contributor.author>Picchioni, M</contributor.author>
<contributor.author>Toulopoulou, T</contributor.author>
<contributor.author>Collier, D</contributor.author>
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Author Affiliations
  1. King's College London
  2. Medical Research Council
  3. McLean Hospital