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Article: Do COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis?

TitleDo COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis?
Authors
KeywordsBDNF
COMT
NRG1
P50
psychosis
Issue Date2011
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
Citation
Psychological Medicine, 2011, v. 41 n. 2, p. 263-276 How to Cite?
Abstract
Background Auditory P50 sensory gating deficits correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease. The well-supported role of catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF) and neuregulin 1 (NRG1) genes in neurodevelopment and cognition make a strong theoretical case for their influence on the P50 endophenotype.Method The possible role of NRG1, COMT Val 158Met and BDNF Val 66Met gene polymorphisms on the P50 endophenotype was examined in a large sample consisting of psychotic patients, their unaffected relatives and unrelated healthy controls using linear regression analyses.Results Although P50 deficits were present in patients and their unaffected relatives, there was no evidence for an association between NRG1, COMT Val 158Met or BDNF Val 66Met genotypes and the P50 endophenotype.Conclusions The evidence from our large study suggests that any such association between P50 indices and NRG1, COMT Val 158Met or BDNF Val 66Met genotypes, if present, must be very subtle. © 2010 Cambridge University Press.
Persistent Identifierhttp://hdl.handle.net/10722/141823
ISSN
2013 Impact Factor: 5.428
ISI Accession Number ID
Funding AgencyGrant Number
Wellcome Trust
Schizophrenia Research Fund
National Alliance for Research on Schizophrenia and Depression
British Medical Association
Psychiatry Research Trust
National Institute for Health Research (NIHR) Biomedical Research Centre
Funding Information:

We are grateful to all those who participated in our research study. This study was funded by the Wellcome Trust, the Schizophrenia Research Fund, the National Alliance for Research on Schizophrenia and Depression, the British Medical Association and the Psychiatry Research Trust. We also thank the National Institute for Health Research (NIHR) Biomedical Research Centre for financial support.

References

 

DC FieldValueLanguage
dc.contributor.authorShaikh, Men_HK
dc.contributor.authorHall, MHen_HK
dc.contributor.authorSchulze, Ken_HK
dc.contributor.authorDutt, Aen_HK
dc.contributor.authorWalshe, Men_HK
dc.contributor.authorWilliams, Ien_HK
dc.contributor.authorConstante, Men_HK
dc.contributor.authorPicchioni, Men_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorCollier, Den_HK
dc.contributor.authorRijsdijk, Fen_HK
dc.contributor.authorPowell, Jen_HK
dc.contributor.authorArranz, Men_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorBramon, Een_HK
dc.date.accessioned2011-09-27T03:02:37Z-
dc.date.available2011-09-27T03:02:37Z-
dc.date.issued2011en_HK
dc.identifier.citationPsychological Medicine, 2011, v. 41 n. 2, p. 263-276en_HK
dc.identifier.issn0033-2917en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141823-
dc.description.abstractBackground Auditory P50 sensory gating deficits correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease. The well-supported role of catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF) and neuregulin 1 (NRG1) genes in neurodevelopment and cognition make a strong theoretical case for their influence on the P50 endophenotype.Method The possible role of NRG1, COMT Val 158Met and BDNF Val 66Met gene polymorphisms on the P50 endophenotype was examined in a large sample consisting of psychotic patients, their unaffected relatives and unrelated healthy controls using linear regression analyses.Results Although P50 deficits were present in patients and their unaffected relatives, there was no evidence for an association between NRG1, COMT Val 158Met or BDNF Val 66Met genotypes and the P50 endophenotype.Conclusions The evidence from our large study suggests that any such association between P50 indices and NRG1, COMT Val 158Met or BDNF Val 66Met genotypes, if present, must be very subtle. © 2010 Cambridge University Press.en_HK
dc.languageengen_US
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSMen_HK
dc.relation.ispartofPsychological Medicineen_HK
dc.subjectBDNFen_HK
dc.subjectCOMTen_HK
dc.subjectNRG1en_HK
dc.subjectP50en_HK
dc.subjectpsychosisen_HK
dc.titleDo COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis?en_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1017/S003329170999239Xen_HK
dc.identifier.pmid20102668-
dc.identifier.scopuseid_2-s2.0-79952819313en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952819313&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume41en_HK
dc.identifier.issue2en_HK
dc.identifier.spage263en_HK
dc.identifier.epage276en_HK
dc.identifier.eissn1469-8978-
dc.identifier.isiWOS:000286072900004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridShaikh, M=24377053800en_HK
dc.identifier.scopusauthoridHall, MH=14013171900en_HK
dc.identifier.scopusauthoridSchulze, K=7103137549en_HK
dc.identifier.scopusauthoridDutt, A=35174289500en_HK
dc.identifier.scopusauthoridWalshe, M=8855469300en_HK
dc.identifier.scopusauthoridWilliams, I=35220818900en_HK
dc.identifier.scopusauthoridConstante, M=36999118800en_HK
dc.identifier.scopusauthoridPicchioni, M=6507443795en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridCollier, D=26642980600en_HK
dc.identifier.scopusauthoridRijsdijk, F=6701830835en_HK
dc.identifier.scopusauthoridPowell, J=7403541196en_HK
dc.identifier.scopusauthoridArranz, M=7006010757en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridBramon, E=8089378900en_HK

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